DC-SCRIPT Regulates IL-10 Production in Human Dendritic Cells by Modulating NF-κBp65 Activation

The balance between tolerance and immunity is important for the outcome of an infection or cancer, and dendritic cells (DCs) are key regulators of this balance. DC-specific transcript (DC-SCRIPT) is a protein expressed by DCs and has been demonstrated to suppress both TLR-mediated expression of IL-1...

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Veröffentlicht in:	The Journal of immunology (1950) 2015-08, Vol.195 (4), p.1498-1505
Hauptverfasser:	Søndergaard, Jonas Nørskov, Poghosyan, Susanna, Hontelez, Saartje, Louche, Pauline, Looman, Maaike W G, Ansems, Marleen, Adema, Gosse J
Format:	Artikel
Sprache:	eng
Schlagworte:	Carrier Proteins - genetics Carrier Proteins - metabolism Dendritic Cells - immunology Dendritic Cells - metabolism Enhancer Elements, Genetic Enzyme Activation Gene Knockout Techniques Humans Interleukin-10 - biosynthesis Interleukin-10 - genetics p300-CBP Transcription Factors - metabolism Phosphorylation Protein Binding Receptors, Glucocorticoid - metabolism RNA Interference Toll-Like Receptors - metabolism Transcription Factor RelA - metabolism Transcription Factors - metabolism
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