Identification of a Novel Splice Variant Isoform of TREM-1 in Human Neutrophil Granules

Triggering receptor expressed on myeloid cells-1 (TREM-1) is critical for inflammatory signal amplification. Humans have two forms of TREM-1: a membrane receptor, associated with the adaptor DAP12, and a soluble receptor detected at times of infection. The membrane receptor isoform acts synergistica...

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Veröffentlicht in:	The Journal of immunology (1950) 2015-12, Vol.195 (12), p.5725-5731
Hauptverfasser:	Baruah, Sankar, Keck, Kathy, Vrenios, Michelle, Pope, Marshall R, Pearl, Merideth, Doerschug, Kevin, Klesney-Tait, Julia
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Degranulation Cells, Cultured Cytoplasmic Granules - metabolism Humans Inflammation Mediators - metabolism Lipopolysaccharides - immunology Lipoproteins - immunology Membrane Glycoproteins - isolation & purification Membrane Glycoproteins - metabolism Neutrophils - metabolism Neutrophils - microbiology Protein Isoforms - isolation & purification Protein Isoforms - metabolism Pseudomonas aeruginosa Pseudomonas aeruginosa - immunology Pseudomonas Infections - immunology Receptors, Immunologic - isolation & purification Receptors, Immunologic - metabolism Sepsis - immunology Signal Transduction Toll-Like Receptors - metabolism Triggering Receptor Expressed on Myeloid Cells-1
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