Distinct CCR7 glycosylation pattern shapes receptor signaling and endocytosis to modulate chemotactic responses

N‐glycosylation of CCR7 is a determinant of CCR7 signaling and T cell migratory capacity which is modulated by glycosidases released from DCs. The homeostatic chemokines CCL19 and CCL21 and their common cognate chemokine receptor CCR7 orchestrate immune cell trafficking by eliciting distinct signali...

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Veröffentlicht in:	Journal of leukocyte biology 2016-06, Vol.99 (6), p.993-1007
Hauptverfasser:	Hauser, Mark A., Kindinger, Ilona, Laufer, Julia M., Späte, Anne‐Katrin, Bucher, Delia, Vanes, Sarah L., Krueger, Wolfgang A., Wittmann, Valentin, Legler, Daniel F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Asparagine - metabolism Binding Sites CCL19/21 Cell Communication Cell Line cell migration Chemokine CCL19 Chemotaxis Dendritic Cells - cytology Dendritic Cells - metabolism dendritic–T cell interaction Endocytosis Glycosylation Humans Immobilized Proteins - metabolism internalization Ligands Models, Molecular Mutant Proteins - metabolism N-Acetylneuraminic Acid - metabolism Polysaccharides - chemistry Receptors, CCR7 - metabolism Signal Transduction Solubility T-Lymphocytes - cytology T-Lymphocytes - metabolism
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