Prognostic Significance of Apoptosis-related Markers in Patients With Soft-Tissue Sarcomas of Extremities

Bcl-2 and Bax proteins are key regulators of apoptosis, a process that is deregulated in many human diseases, particularly cancer. Overexpression of antiapoptotic Bcl-2 protein is associated with drug resistance and poor clinical outcome in cancer patients, whereas the expression of proapoptotic Bax...

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Veröffentlicht in:	Applied immunohistochemistry & molecular morphology 2016-04, Vol.24 (4), p.268-274
Hauptverfasser:	Mühlbeier, Diego F M, Saddi, Vera A, de Paula, Élbio C, Cunha, Isabela W, Fregnani, José H T G, Barbosa, Maria A, Manoel, Wilmar J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Apoptosis bcl-2-Associated X Protein - metabolism Biomarkers, Tumor - metabolism Female Humans Immunohistochemistry Male Prognosis Proto-Oncogene Proteins c-bcl-2 - metabolism Sarcoma - metabolism Sarcoma - pathology Survival Analysis
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