PILRα negatively regulates mouse inflammatory arthritis

Paired Ig-like type 2 receptor (PILR)α inhibitory receptor and its counterpart PILRβ activating receptor are coexpressed on myeloid cells. In this article, we report that PILRα, but not PILRβ, is elevated in human rheumatoid arthritis synovial tissue and correlates with inflammatory cell infiltratio...

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Veröffentlicht in:	The Journal of immunology (1950) 2014-07, Vol.193 (2), p.860-870
Hauptverfasser:	Sun, Yonglian, Caplazi, Patrick, Zhang, Juan, Mazloom, Anita, Kummerfeld, Sarah, Quinones, Gabriel, Senger, Kate, Lesch, Justin, Peng, Ivan, Sebrell, Andrew, Luk, Wilman, Lu, Yanmei, Lin, Zhonghua, Barck, Kai, Young, Judy, Del Rio, Mariela, Lehar, Sophie, Asghari, Vida, Lin, WeiYu, Mariathasan, Sanjeev, DeVoss, Jason, Misaghi, Shahram, Balazs, Mercedesz, Sai, Tao, Haley, Benjamin, Hass, Philip E, Xu, Min, Ouyang, Wenjun, Martin, Flavius, Lee, Wyne P, Zarrin, Ali A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - immunology Antibodies, Monoclonal - pharmacology Arthritis, Experimental - immunology Arthritis, Experimental - metabolism Arthritis, Experimental - prevention & control Arthritis, Rheumatoid - drug therapy Arthritis, Rheumatoid - genetics Arthritis, Rheumatoid - immunology Cells, Cultured Cytokines - immunology Cytokines - metabolism Female Flow Cytometry HEK293 Cells Hindlimb - drug effects Hindlimb - immunology Hindlimb - pathology Humans Immunohistochemistry Inflammation - immunology Inflammation - metabolism Inflammation - prevention & control Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Knockout Oligonucleotide Array Sequence Analysis Osteoarthritis - drug therapy Osteoarthritis - genetics Osteoarthritis - immunology Receptors, Immunologic - genetics Receptors, Immunologic - immunology Receptors, Immunologic - metabolism Reverse Transcriptase Polymerase Chain Reaction Transcriptome - genetics Transcriptome - immunology
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