PILRα negatively regulates mouse inflammatory arthritis
Paired Ig-like type 2 receptor (PILR)α inhibitory receptor and its counterpart PILRβ activating receptor are coexpressed on myeloid cells. In this article, we report that PILRα, but not PILRβ, is elevated in human rheumatoid arthritis synovial tissue and correlates with inflammatory cell infiltratio...
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| Veröffentlicht in: | The Journal of immunology (1950) 2014-07, Vol.193 (2), p.860-870 |
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| container_title | The Journal of immunology (1950) |
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| creator | Sun, Yonglian Caplazi, Patrick Zhang, Juan Mazloom, Anita Kummerfeld, Sarah Quinones, Gabriel Senger, Kate Lesch, Justin Peng, Ivan Sebrell, Andrew Luk, Wilman Lu, Yanmei Lin, Zhonghua Barck, Kai Young, Judy Del Rio, Mariela Lehar, Sophie Asghari, Vida Lin, WeiYu Mariathasan, Sanjeev DeVoss, Jason Misaghi, Shahram Balazs, Mercedesz Sai, Tao Haley, Benjamin Hass, Philip E Xu, Min Ouyang, Wenjun Martin, Flavius Lee, Wyne P Zarrin, Ali A |
| description | Paired Ig-like type 2 receptor (PILR)α inhibitory receptor and its counterpart PILRβ activating receptor are coexpressed on myeloid cells. In this article, we report that PILRα, but not PILRβ, is elevated in human rheumatoid arthritis synovial tissue and correlates with inflammatory cell infiltration. Pilrα(-/-) mice produce more pathogenic cytokines during inflammation and are prone to enhanced autoimmune arthritis. Correspondingly, engaging PILRα with anti-PILRα mAb ameliorates inflammation in mouse arthritis models and suppresses the production of proinflammatory cytokines. Our studies suggest that PILRα mediates an important inhibitory pathway that can dampen inflammatory responses. |
| doi_str_mv | 10.4049/jimmunol.1400045 |
| format | Article |
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In this article, we report that PILRα, but not PILRβ, is elevated in human rheumatoid arthritis synovial tissue and correlates with inflammatory cell infiltration. Pilrα(-/-) mice produce more pathogenic cytokines during inflammation and are prone to enhanced autoimmune arthritis. Correspondingly, engaging PILRα with anti-PILRα mAb ameliorates inflammation in mouse arthritis models and suppresses the production of proinflammatory cytokines. Our studies suggest that PILRα mediates an important inhibitory pathway that can dampen inflammatory responses.</description><identifier>ISSN: 0022-1767</identifier><identifier>EISSN: 1550-6606</identifier><identifier>DOI: 10.4049/jimmunol.1400045</identifier><identifier>PMID: 24935926</identifier><language>eng</language><publisher>United States</publisher><subject>Animals ; Antibodies, Monoclonal - immunology ; Antibodies, Monoclonal - pharmacology ; Arthritis, Experimental - immunology ; Arthritis, Experimental - metabolism ; Arthritis, Experimental - prevention & control ; Arthritis, Rheumatoid - drug therapy ; Arthritis, Rheumatoid - genetics ; Arthritis, Rheumatoid - immunology ; Cells, Cultured ; Cytokines - immunology ; Cytokines - metabolism ; Female ; Flow Cytometry ; HEK293 Cells ; Hindlimb - drug effects ; Hindlimb - immunology ; Hindlimb - pathology ; Humans ; Immunohistochemistry ; Inflammation - immunology ; Inflammation - metabolism ; Inflammation - prevention & control ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Mice, Knockout ; Oligonucleotide Array Sequence Analysis ; Osteoarthritis - drug therapy ; Osteoarthritis - genetics ; Osteoarthritis - immunology ; Receptors, Immunologic - genetics ; Receptors, Immunologic - immunology ; Receptors, Immunologic - metabolism ; Reverse Transcriptase Polymerase Chain Reaction ; Transcriptome - genetics ; Transcriptome - immunology</subject><ispartof>The Journal of immunology (1950), 2014-07, Vol.193 (2), p.860-870</ispartof><rights>Copyright © 2014 by The American Association of Immunologists, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c374t-1ecbde5dbbda392e6705f4d5a36e517cf67cbc7d35c8a30619a49ef998bb75cf3</citedby><cites>FETCH-LOGICAL-c374t-1ecbde5dbbda392e6705f4d5a36e517cf67cbc7d35c8a30619a49ef998bb75cf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27928,27929</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24935926$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sun, Yonglian</creatorcontrib><creatorcontrib>Caplazi, Patrick</creatorcontrib><creatorcontrib>Zhang, Juan</creatorcontrib><creatorcontrib>Mazloom, Anita</creatorcontrib><creatorcontrib>Kummerfeld, Sarah</creatorcontrib><creatorcontrib>Quinones, Gabriel</creatorcontrib><creatorcontrib>Senger, Kate</creatorcontrib><creatorcontrib>Lesch, Justin</creatorcontrib><creatorcontrib>Peng, Ivan</creatorcontrib><creatorcontrib>Sebrell, Andrew</creatorcontrib><creatorcontrib>Luk, Wilman</creatorcontrib><creatorcontrib>Lu, Yanmei</creatorcontrib><creatorcontrib>Lin, Zhonghua</creatorcontrib><creatorcontrib>Barck, Kai</creatorcontrib><creatorcontrib>Young, Judy</creatorcontrib><creatorcontrib>Del Rio, Mariela</creatorcontrib><creatorcontrib>Lehar, Sophie</creatorcontrib><creatorcontrib>Asghari, Vida</creatorcontrib><creatorcontrib>Lin, WeiYu</creatorcontrib><creatorcontrib>Mariathasan, Sanjeev</creatorcontrib><creatorcontrib>DeVoss, Jason</creatorcontrib><creatorcontrib>Misaghi, Shahram</creatorcontrib><creatorcontrib>Balazs, Mercedesz</creatorcontrib><creatorcontrib>Sai, Tao</creatorcontrib><creatorcontrib>Haley, Benjamin</creatorcontrib><creatorcontrib>Hass, Philip E</creatorcontrib><creatorcontrib>Xu, Min</creatorcontrib><creatorcontrib>Ouyang, Wenjun</creatorcontrib><creatorcontrib>Martin, Flavius</creatorcontrib><creatorcontrib>Lee, Wyne P</creatorcontrib><creatorcontrib>Zarrin, Ali A</creatorcontrib><title>PILRα negatively regulates mouse inflammatory arthritis</title><title>The Journal of immunology (1950)</title><addtitle>J Immunol</addtitle><description>Paired Ig-like type 2 receptor (PILR)α inhibitory receptor and its counterpart PILRβ activating receptor are coexpressed on myeloid cells. In this article, we report that PILRα, but not PILRβ, is elevated in human rheumatoid arthritis synovial tissue and correlates with inflammatory cell infiltration. Pilrα(-/-) mice produce more pathogenic cytokines during inflammation and are prone to enhanced autoimmune arthritis. Correspondingly, engaging PILRα with anti-PILRα mAb ameliorates inflammation in mouse arthritis models and suppresses the production of proinflammatory cytokines. Our studies suggest that PILRα mediates an important inhibitory pathway that can dampen inflammatory responses.</description><subject>Animals</subject><subject>Antibodies, Monoclonal - immunology</subject><subject>Antibodies, Monoclonal - pharmacology</subject><subject>Arthritis, Experimental - immunology</subject><subject>Arthritis, Experimental - metabolism</subject><subject>Arthritis, Experimental - prevention & control</subject><subject>Arthritis, Rheumatoid - drug therapy</subject><subject>Arthritis, Rheumatoid - genetics</subject><subject>Arthritis, Rheumatoid - immunology</subject><subject>Cells, Cultured</subject><subject>Cytokines - immunology</subject><subject>Cytokines - metabolism</subject><subject>Female</subject><subject>Flow Cytometry</subject><subject>HEK293 Cells</subject><subject>Hindlimb - drug effects</subject><subject>Hindlimb - immunology</subject><subject>Hindlimb - pathology</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Inflammation - immunology</subject><subject>Inflammation - metabolism</subject><subject>Inflammation - prevention & control</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Knockout</subject><subject>Oligonucleotide Array Sequence Analysis</subject><subject>Osteoarthritis - drug therapy</subject><subject>Osteoarthritis - genetics</subject><subject>Osteoarthritis - immunology</subject><subject>Receptors, Immunologic - genetics</subject><subject>Receptors, Immunologic - immunology</subject><subject>Receptors, Immunologic - metabolism</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>Transcriptome - genetics</subject><subject>Transcriptome - immunology</subject><issn>0022-1767</issn><issn>1550-6606</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtKw0AYhQdRbK3uXUmWblL_uWeWUrwUCoroOkwmf2pKpqkzidDH8kV8JiNt3bo6m-8cDh8hlxSmAoS5WdXe9-u2mVIBAEIekTGVElKlQB2TMQBjKdVKj8hZjKsBUcDEKRkxYbg0TI1J9jxfvHx_JWtc2q7-xGabBFz2je0wJr7tIyb1umqs97ZrwzaxoXsPdVfHc3JS2SbixT4n5O3-7nX2mC6eHuaz20XquBZdStEVJcqyKErLDUOlQVailJYrlFS7SmlXOF1y6TLLQVFjhcHKmKwotHQVn5Dr3e4mtB89xi73dXTYNHaNw72cZpApLZjh_6NScJYJmekBhR3qQhtjwCrfhNrbsM0p5L9q84PafK92qFzt1_vCY_lXOLjkP2exd_M</recordid><startdate>20140715</startdate><enddate>20140715</enddate><creator>Sun, Yonglian</creator><creator>Caplazi, Patrick</creator><creator>Zhang, Juan</creator><creator>Mazloom, Anita</creator><creator>Kummerfeld, Sarah</creator><creator>Quinones, Gabriel</creator><creator>Senger, Kate</creator><creator>Lesch, Justin</creator><creator>Peng, Ivan</creator><creator>Sebrell, Andrew</creator><creator>Luk, Wilman</creator><creator>Lu, Yanmei</creator><creator>Lin, Zhonghua</creator><creator>Barck, Kai</creator><creator>Young, Judy</creator><creator>Del Rio, Mariela</creator><creator>Lehar, Sophie</creator><creator>Asghari, Vida</creator><creator>Lin, WeiYu</creator><creator>Mariathasan, Sanjeev</creator><creator>DeVoss, Jason</creator><creator>Misaghi, Shahram</creator><creator>Balazs, Mercedesz</creator><creator>Sai, Tao</creator><creator>Haley, Benjamin</creator><creator>Hass, Philip E</creator><creator>Xu, Min</creator><creator>Ouyang, Wenjun</creator><creator>Martin, Flavius</creator><creator>Lee, Wyne P</creator><creator>Zarrin, Ali A</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>20140715</creationdate><title>PILRα negatively regulates mouse inflammatory arthritis</title><author>Sun, Yonglian ; Caplazi, Patrick ; Zhang, Juan ; Mazloom, Anita ; Kummerfeld, Sarah ; Quinones, Gabriel ; Senger, Kate ; Lesch, Justin ; Peng, Ivan ; Sebrell, Andrew ; Luk, Wilman ; Lu, Yanmei ; Lin, Zhonghua ; Barck, Kai ; Young, Judy ; Del Rio, Mariela ; Lehar, Sophie ; Asghari, Vida ; Lin, WeiYu ; Mariathasan, Sanjeev ; DeVoss, Jason ; Misaghi, Shahram ; Balazs, Mercedesz ; Sai, Tao ; Haley, Benjamin ; Hass, Philip E ; Xu, Min ; Ouyang, Wenjun ; Martin, Flavius ; Lee, Wyne P ; Zarrin, Ali A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c374t-1ecbde5dbbda392e6705f4d5a36e517cf67cbc7d35c8a30619a49ef998bb75cf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Animals</topic><topic>Antibodies, Monoclonal - 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In this article, we report that PILRα, but not PILRβ, is elevated in human rheumatoid arthritis synovial tissue and correlates with inflammatory cell infiltration. Pilrα(-/-) mice produce more pathogenic cytokines during inflammation and are prone to enhanced autoimmune arthritis. Correspondingly, engaging PILRα with anti-PILRα mAb ameliorates inflammation in mouse arthritis models and suppresses the production of proinflammatory cytokines. Our studies suggest that PILRα mediates an important inhibitory pathway that can dampen inflammatory responses.</abstract><cop>United States</cop><pmid>24935926</pmid><doi>10.4049/jimmunol.1400045</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The Journal of immunology (1950), 2014-07, Vol.193 (2), p.860-870 |
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| subjects | Animals Antibodies, Monoclonal - immunology Antibodies, Monoclonal - pharmacology Arthritis, Experimental - immunology Arthritis, Experimental - metabolism Arthritis, Experimental - prevention & control Arthritis, Rheumatoid - drug therapy Arthritis, Rheumatoid - genetics Arthritis, Rheumatoid - immunology Cells, Cultured Cytokines - immunology Cytokines - metabolism Female Flow Cytometry HEK293 Cells Hindlimb - drug effects Hindlimb - immunology Hindlimb - pathology Humans Immunohistochemistry Inflammation - immunology Inflammation - metabolism Inflammation - prevention & control Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Knockout Oligonucleotide Array Sequence Analysis Osteoarthritis - drug therapy Osteoarthritis - genetics Osteoarthritis - immunology Receptors, Immunologic - genetics Receptors, Immunologic - immunology Receptors, Immunologic - metabolism Reverse Transcriptase Polymerase Chain Reaction Transcriptome - genetics Transcriptome - immunology |
| title | PILRα negatively regulates mouse inflammatory arthritis |
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