Enhancement of the synthesis of n-3 PUFAs in fat-1 transgenic mice inhibits mTORC1 signalling and delays surgically induced osteoarthritis in comparison with wild-type mice

Background An exogenous supplement of n-3 polyunsaturated fatty acids (PUFAs) has been reported to prevent osteoarthritis (OA) through undefined mechanisms. Objective This study investigated the effect of alterations in the composition of endogenous PUFAs on OA, and associations of PUFAs with mammal...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Annals of the rheumatic diseases 2014-09, Vol.73 (9), p.1719-1727
Hauptverfasser:	Huang, Min-jun, Wang, Liang, Jin, Da-di, Zhang, Zhong-min, Chen, Tian-yu, Jia, Chun-hong, Wang, Yan, Zhen, Xiao-chen, Huang, Bin, Yan, Bo, Chen, Yu-hui, Li, Sheng-fa, Yang, Jin-cheng, Dai, Yi-fan, Bai, Xiao-chun
Format:	Artikel
Sprache:	eng
Schlagworte:	ADAM Proteins - metabolism ADAMTS5 Protein Animals Arthritis, Experimental - etiology Arthritis, Experimental - pathology Arthritis, Experimental - prevention & control Autophagy Autophagy - physiology Cadherins - genetics Cartilage, Articular - metabolism Cartilage, Articular - ultrastructure Chondrocytes - pathology Clinical medicine Disease Progression Enzymes Fatty Acids, Omega-3 - biosynthesis Fatty Acids, Omega-3 - physiology Fatty Acids, Omega-6 - biosynthesis Female Knee Laboratory animals Mammals Matrix Metalloproteinase 13 - metabolism Mechanistic Target of Rapamycin Complex 1 Medical research Metabolism Mice Mice, Inbred C57BL Mice, Transgenic Microscopy, Electron, Scanning Multiprotein Complexes - physiology Osteoarthritis - etiology Osteoarthritis - pathology Osteoarthritis - prevention & control Pathogenesis Proteoglycans - metabolism Rodents Signal Transduction - physiology Studies TOR Serine-Threonine Kinases - physiology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!