Potential diagnostic and prognostic biomarkers for cholangiocarcinoma in serum and bile
Cholangiocarcinoma (CCA) is a devastating malignancy that is difficult to treat because of its insensitivity to conventional therapies and the inability to detect early tumor formation. Novel molecular techniques have enabled the use of serum and bile markers for CCA diagnosis and prognosis. Herein,...
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| Veröffentlicht in: | Biomarkers in medicine 2016-06, Vol.10 (6), p.613-619 |
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| creator | Wang, Bin Chen, Liang Chang, Hao-Teng |
| description | Cholangiocarcinoma (CCA) is a devastating malignancy that is difficult to treat because of its insensitivity to conventional therapies and the inability to detect early tumor formation. Novel molecular techniques have enabled the use of serum and bile markers for CCA diagnosis and prognosis. Herein, we summarize the principal characteristics of serum and bile markers of CCA. Biomarkers such as interleukin-6, matrix metalloproteinases, serotonin (5-hydroxytryptamine) and bile acids have shown promise for improving CCA diagnosis. Several markers such as CYFRA 21-1, MK-1 and C-reactive protein were recently shown to be effective for CCA prognosis. |
| doi_str_mv | 10.2217/bmm-2015-0062 |
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Novel molecular techniques have enabled the use of serum and bile markers for CCA diagnosis and prognosis. Herein, we summarize the principal characteristics of serum and bile markers of CCA. Biomarkers such as interleukin-6, matrix metalloproteinases, serotonin (5-hydroxytryptamine) and bile acids have shown promise for improving CCA diagnosis. Several markers such as CYFRA 21-1, MK-1 and C-reactive protein were recently shown to be effective for CCA prognosis.</description><identifier>ISSN: 1752-0363</identifier><identifier>EISSN: 1752-0371</identifier><identifier>DOI: 10.2217/bmm-2015-0062</identifier><identifier>PMID: 27232281</identifier><language>eng</language><publisher>England: Future Medicine Ltd</publisher><subject>Antigens ; Antigens, Neoplasm - blood ; Antigens, Tumor-Associated, Carbohydrate - blood ; Apoptosis ; Bile ; Bile acids ; Bile Acids and Salts - analysis ; Bile Duct Neoplasms - diagnosis ; biomarker ; Biomarkers ; Biomarkers, Tumor - blood ; Biopsy ; C-reactive protein ; C-Reactive Protein - analysis ; Cholangiocarcinoma ; Cholangiocarcinoma - diagnosis ; Cholangiocarcinoma - pathology ; Clinical medicine ; Colorectal cancer ; Cytokines ; Diagnosis ; Endoscopy ; Enzymes ; Epithelial Cell Adhesion Molecule - blood ; Humans ; Interleukin 6 ; Interleukin-6 - analysis ; Keratin-19 - blood ; Kinases ; Liver ; Malignancy ; Matrix metalloproteinase ; Mucins - blood ; Pancreatic cancer ; Prognosis ; Serotonin ; Serotonin - analysis ; serum</subject><ispartof>Biomarkers in medicine, 2016-06, Vol.10 (6), p.613-619</ispartof><rights>Hao-Teng Chang</rights><rights>2016. 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Novel molecular techniques have enabled the use of serum and bile markers for CCA diagnosis and prognosis. Herein, we summarize the principal characteristics of serum and bile markers of CCA. Biomarkers such as interleukin-6, matrix metalloproteinases, serotonin (5-hydroxytryptamine) and bile acids have shown promise for improving CCA diagnosis. Several markers such as CYFRA 21-1, MK-1 and C-reactive protein were recently shown to be effective for CCA prognosis.</description><subject>Antigens</subject><subject>Antigens, Neoplasm - blood</subject><subject>Antigens, Tumor-Associated, Carbohydrate - blood</subject><subject>Apoptosis</subject><subject>Bile</subject><subject>Bile acids</subject><subject>Bile Acids and Salts - analysis</subject><subject>Bile Duct Neoplasms - diagnosis</subject><subject>biomarker</subject><subject>Biomarkers</subject><subject>Biomarkers, Tumor - blood</subject><subject>Biopsy</subject><subject>C-reactive protein</subject><subject>C-Reactive Protein - analysis</subject><subject>Cholangiocarcinoma</subject><subject>Cholangiocarcinoma - diagnosis</subject><subject>Cholangiocarcinoma - pathology</subject><subject>Clinical medicine</subject><subject>Colorectal cancer</subject><subject>Cytokines</subject><subject>Diagnosis</subject><subject>Endoscopy</subject><subject>Enzymes</subject><subject>Epithelial Cell Adhesion Molecule - blood</subject><subject>Humans</subject><subject>Interleukin 6</subject><subject>Interleukin-6 - analysis</subject><subject>Keratin-19 - blood</subject><subject>Kinases</subject><subject>Liver</subject><subject>Malignancy</subject><subject>Matrix metalloproteinase</subject><subject>Mucins - blood</subject><subject>Pancreatic cancer</subject><subject>Prognosis</subject><subject>Serotonin</subject><subject>Serotonin - analysis</subject><subject>serum</subject><issn>1752-0363</issn><issn>1752-0371</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkb1PwzAQxS0EoqUwsqJILCwB-1x_ZEQVX1IlGECMluM4xSWJi50M_Pe4tHRAQkz2nX_3dH4PoVOCLwGIuCrbNgdMWI4xhz00JoJBjqkg-7s7pyN0FOMSYyYEh0M0AgEUQJIxen3yve16p5uscnrR-dg7k-muylbB_5Sl860O7zbErPYhM2--0d3CeaODcV16y1yXRRuG9nuydI09Rge1bqI92Z4T9HJ78zy7z-ePdw-z63luGC76vIKSSMIlLVnFqeBYFHoqzHTd5MCZkKXUvKoJIUCxAEELm9pTMa1LTklBJ-hio5vW_Rhs7FXrorFNWtD6ISoiseSCUk7-R0XBJMcMZELPf6FLP4QufUQBw0CK5CRPVL6hTPAxBlurVXDJqE9FsFqHo1I4ah2OWoeT-LOt6lC2ttrRP2kkoNgA9dAPwUbjbGes2lRpwiW37R_iX5gom1g</recordid><startdate>20160601</startdate><enddate>20160601</enddate><creator>Wang, Bin</creator><creator>Chen, Liang</creator><creator>Chang, Hao-Teng</creator><general>Future Medicine Ltd</general><scope>FUMOA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>EHMNL</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20160601</creationdate><title>Potential diagnostic and prognostic biomarkers for cholangiocarcinoma in serum and bile</title><author>Wang, Bin ; Chen, Liang ; Chang, Hao-Teng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c509t-d2b181683b5d6376079a47c41816626578b8a6df11123072739e265474fb63193</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Antigens</topic><topic>Antigens, Neoplasm - blood</topic><topic>Antigens, Tumor-Associated, Carbohydrate - blood</topic><topic>Apoptosis</topic><topic>Bile</topic><topic>Bile acids</topic><topic>Bile Acids and Salts - analysis</topic><topic>Bile Duct Neoplasms - diagnosis</topic><topic>biomarker</topic><topic>Biomarkers</topic><topic>Biomarkers, Tumor - blood</topic><topic>Biopsy</topic><topic>C-reactive protein</topic><topic>C-Reactive Protein - analysis</topic><topic>Cholangiocarcinoma</topic><topic>Cholangiocarcinoma - diagnosis</topic><topic>Cholangiocarcinoma - pathology</topic><topic>Clinical medicine</topic><topic>Colorectal cancer</topic><topic>Cytokines</topic><topic>Diagnosis</topic><topic>Endoscopy</topic><topic>Enzymes</topic><topic>Epithelial Cell Adhesion Molecule - blood</topic><topic>Humans</topic><topic>Interleukin 6</topic><topic>Interleukin-6 - analysis</topic><topic>Keratin-19 - blood</topic><topic>Kinases</topic><topic>Liver</topic><topic>Malignancy</topic><topic>Matrix metalloproteinase</topic><topic>Mucins - blood</topic><topic>Pancreatic cancer</topic><topic>Prognosis</topic><topic>Serotonin</topic><topic>Serotonin - analysis</topic><topic>serum</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Bin</creatorcontrib><creatorcontrib>Chen, Liang</creatorcontrib><creatorcontrib>Chang, Hao-Teng</creatorcontrib><collection>Future Medicine (Open Access)</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>UK & Ireland Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Biomarkers in medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Bin</au><au>Chen, Liang</au><au>Chang, Hao-Teng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Potential diagnostic and prognostic biomarkers for cholangiocarcinoma in serum and bile</atitle><jtitle>Biomarkers in medicine</jtitle><addtitle>Biomark Med</addtitle><date>2016-06-01</date><risdate>2016</risdate><volume>10</volume><issue>6</issue><spage>613</spage><epage>619</epage><pages>613-619</pages><issn>1752-0363</issn><eissn>1752-0371</eissn><abstract>Cholangiocarcinoma (CCA) is a devastating malignancy that is difficult to treat because of its insensitivity to conventional therapies and the inability to detect early tumor formation. Novel molecular techniques have enabled the use of serum and bile markers for CCA diagnosis and prognosis. Herein, we summarize the principal characteristics of serum and bile markers of CCA. Biomarkers such as interleukin-6, matrix metalloproteinases, serotonin (5-hydroxytryptamine) and bile acids have shown promise for improving CCA diagnosis. Several markers such as CYFRA 21-1, MK-1 and C-reactive protein were recently shown to be effective for CCA prognosis.</abstract><cop>England</cop><pub>Future Medicine Ltd</pub><pmid>27232281</pmid><doi>10.2217/bmm-2015-0062</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Antigens Antigens, Neoplasm - blood Antigens, Tumor-Associated, Carbohydrate - blood Apoptosis Bile Bile acids Bile Acids and Salts - analysis Bile Duct Neoplasms - diagnosis biomarker Biomarkers Biomarkers, Tumor - blood Biopsy C-reactive protein C-Reactive Protein - analysis Cholangiocarcinoma Cholangiocarcinoma - diagnosis Cholangiocarcinoma - pathology Clinical medicine Colorectal cancer Cytokines Diagnosis Endoscopy Enzymes Epithelial Cell Adhesion Molecule - blood Humans Interleukin 6 Interleukin-6 - analysis Keratin-19 - blood Kinases Liver Malignancy Matrix metalloproteinase Mucins - blood Pancreatic cancer Prognosis Serotonin Serotonin - analysis serum |
| title | Potential diagnostic and prognostic biomarkers for cholangiocarcinoma in serum and bile |
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