CX3CL1/CX3CR1 Axis Plays a Key Role in Ischemia-Induced Oligodendrocyte Injury via p38MAPK Signaling Pathway

Based on current knowledge on the role of the CX3CL1/CX3CR1 axis in the regulation of microglial activation and on the involvement of activated microglia in damaging oligodendrocytes, we hypothesized that CX3CL1/CX3CR1 axis is associated with the development of ischemic oligodendrocyte and white mat...

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Veröffentlicht in:	Molecular neurobiology 2016-08, Vol.53 (6), p.4010-4018
Hauptverfasser:	Wu, Xiao-Mei, Liu, Yong, Qian, Zhong-Ming, Luo, Qian-Qian, Ke, Ya
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Biomedical and Life Sciences Biomedicine Cell Biology Cell Proliferation Chemokine CX3CL1 - metabolism Coculture Techniques CX3C Chemokine Receptor 1 - metabolism Glucose - deficiency Humans Interleukin-1beta - metabolism Ischemia Ischemia - pathology Mice Microglia - metabolism Myelin Sheath - metabolism Neurobiology Neurology Neurosciences Oligodendroglia - metabolism Oligodendroglia - pathology Oxygen p38 Mitogen-Activated Protein Kinases - metabolism Phosphorylation Proteolipids - metabolism RNA, Small Interfering - metabolism Signal Transduction Traumatic brain injury Tumor Necrosis Factor-alpha - metabolism
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