Protease inhibitor monotherapy is effective in controlling human immunodeficiency virus 1 shedding in the male genital tract: Virology
Cross-sectional study comparing seminal human immunodeficiency virus type 1 (HIV-1) shedding in patients receiving boosted protease inhibitor monotherapy (mtPI/rtv) (n = 66) versus triple therapy (TT) (n = 61). Seminal HIV-1 shedding rates in patients with undetectable plasma HIV-RNA were 16.0% on m...
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| Veröffentlicht in: | Clinical microbiology and infection 2016-01, Vol.22 (1), p.98.e7-98.e10 |
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| container_end_page | 98.e10 |
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| container_issue | 1 |
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| container_title | Clinical microbiology and infection |
| container_volume | 22 |
| creator | Torres-Cornejo, A BenMarzouk-Hidalgo, O J Viciana, P Sanchez, B Lopez-Ruz, MA Lopez-Cortes, L F Gutierrez-Valencia, A |
| description | Cross-sectional study comparing seminal human immunodeficiency virus type 1 (HIV-1) shedding in patients receiving boosted protease inhibitor monotherapy (mtPI/rtv) (n = 66) versus triple therapy (TT) (n = 61). Seminal HIV-1 shedding rates in patients with undetectable plasma HIV-RNA were 16.0% on mtPI/rtv compared with 28.6% on TT (p 0.173). Aviraemic status and time on viral suppression were independently associated with lack of seminal HIV-1 shedding. During TT, non PI/rtv-based regimens were associated with a better control of HIV infection in semen despite similar time on viral suppression. The use of mtPI/rtv in well-controlled patients is not associated with increased seminal HIV excretion compared with TT. |
| doi_str_mv | 10.1016/j.cmi.2015.09.028 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 1198-743X |
| ispartof | Clinical microbiology and infection, 2016-01, Vol.22 (1), p.98.e7-98.e10 |
| issn | 1198-743X |
| language | eng |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Human immunodeficiency virus Human immunodeficiency virus 1 Lentivirus Retroviridae |
| title | Protease inhibitor monotherapy is effective in controlling human immunodeficiency virus 1 shedding in the male genital tract: Virology |
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