Nondisruptive p53 Mutations Are Associated with Shorter Survival in Patients with Advanced Non-Small Cell Lung Cancer

TP53 mutations in early-stage non-small cell lung cancer (NSCLC) may be associated with worse survival but their prognostic role in advanced NSCLC is controversial. In addition, it remains unclear whether mutated patients represent a clinically homogeneous group. We retrospectively examined TP53 mut...

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Veröffentlicht in:	Clinical cancer research 2014-09, Vol.20 (17), p.4647-4659
Hauptverfasser:	MOLINA-VILA, Miguel A, BERTRAN-ALAMILLO, Jordi, MAJEM, Margarita, MASSUTI, Bartomeu, MORAN, Teresa, CARCERENY, Enric, VITERI, Santiago, ROSELL, Rafael, GASCO, Amaya, MAYO-DE-LAS-CASAS, Clara, SANCHEZ-RONCO, María, PUJANTELL-PASTOR, Laia, BONANNO, Laura, FAVARETTO, Adolfo G, CARDONA, Andrés F, VERGNENEGRE, Alain
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Antineoplastic agents Biological and medical sciences Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - pathology Disease-Free Survival Female Humans Male Medical sciences Middle Aged Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Mutation - genetics Neoplasm Staging Pharmacology. Drug treatments Pneumology Prognosis Receptor, Epidermal Growth Factor Tumor Suppressor Protein p53 - genetics Tumors Tumors of the respiratory system and mediastinum
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