Genetic characteristics of mumps viruses isolated in Korea from 2007 to 2012
Mumps is a vaccine‐preventable viral disease. Despite vaccine coverage of >95%, the incidence of mumps has increased in Korea since 2007. This study aimed to genetically characterize mumps virus (MuV) strains that circulated in Korea between 2007 and 2012 to determine the factors underlying mumps...
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| Veröffentlicht in: | Journal of medical virology 2016-09, Vol.88 (9), p.1479-1486 |
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| container_title | Journal of medical virology |
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| creator | Kim, Seung Tae Kim, You-Jin Yang, Jeong-Sun Nam, Jeong-Gu Kim, Kisoon Kim, Sung Soon Kang, Hae Ji |
| description | Mumps is a vaccine‐preventable viral disease. Despite vaccine coverage of >95%, the incidence of mumps has increased in Korea since 2007. This study aimed to genetically characterize mumps virus (MuV) strains that circulated in Korea between 2007 and 2012 to determine the factors underlying mumps outbreaks. MuV was isolated from 175 clinical specimens between 2007 and 2012 in Korea. Upon analysis of the SH gene in Korean mumps virus isolates, three different genotypes were identified: I, H, and F. The MuV genotypes I and H co‐circulated in Korea, and eight isolates of Korean genotype F were found within the same time period in 2008. An analysis of HN amino‐acid sequence data showed that Korean isolates had no changes in their glycosylation sites. At putative neutralizing epitope sites, the Jeryl‐Lynn strain showed 4–5 different amino acid sequences from those observed in Korean isolates. Korean isolates of genotypes I and H shared distinctive point mutations on putative neutralizing epitope positions in each genotype. This report describes the genetic characteristics of MuV strains circulating in Korea and provides information on endemic mumps infections. This information may be important to help prevent mumps and control outbreaks of mumps in Korea. J. Med. Virol. 88:1479–1486, 2016. © 2016 Wiley Periodicals, Inc. |
| doi_str_mv | 10.1002/jmv.24515 |
| format | Article |
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Despite vaccine coverage of >95%, the incidence of mumps has increased in Korea since 2007. This study aimed to genetically characterize mumps virus (MuV) strains that circulated in Korea between 2007 and 2012 to determine the factors underlying mumps outbreaks. MuV was isolated from 175 clinical specimens between 2007 and 2012 in Korea. Upon analysis of the SH gene in Korean mumps virus isolates, three different genotypes were identified: I, H, and F. The MuV genotypes I and H co‐circulated in Korea, and eight isolates of Korean genotype F were found within the same time period in 2008. An analysis of HN amino‐acid sequence data showed that Korean isolates had no changes in their glycosylation sites. At putative neutralizing epitope sites, the Jeryl‐Lynn strain showed 4–5 different amino acid sequences from those observed in Korean isolates. Korean isolates of genotypes I and H shared distinctive point mutations on putative neutralizing epitope positions in each genotype. This report describes the genetic characteristics of MuV strains circulating in Korea and provides information on endemic mumps infections. This information may be important to help prevent mumps and control outbreaks of mumps in Korea. J. Med. Virol. 88:1479–1486, 2016. © 2016 Wiley Periodicals, Inc.</description><identifier>ISSN: 0146-6615</identifier><identifier>EISSN: 1096-9071</identifier><identifier>DOI: 10.1002/jmv.24515</identifier><identifier>PMID: 26950767</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Disease Outbreaks ; Epitopes - immunology ; genetic variability ; Genetic Variation ; Genotype ; Genotype & phenotype ; Humans ; Mumps - epidemiology ; Mumps - virology ; Mumps virus ; Mumps virus - classification ; Mumps virus - genetics ; Mumps virus - isolation & purification ; Phylogeny ; Republic of Korea - epidemiology ; RNA, Viral - genetics ; Sequence Alignment ; Viral Proteins - genetics ; Virology ; Viruses</subject><ispartof>Journal of medical virology, 2016-09, Vol.88 (9), p.1479-1486</ispartof><rights>2016 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4945-759935f51d20433157db331129faaa38532008f499eb353501670e0dad2a5a263</citedby><cites>FETCH-LOGICAL-c4945-759935f51d20433157db331129faaa38532008f499eb353501670e0dad2a5a263</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjmv.24515$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjmv.24515$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26950767$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Seung Tae</creatorcontrib><creatorcontrib>Kim, You-Jin</creatorcontrib><creatorcontrib>Yang, Jeong-Sun</creatorcontrib><creatorcontrib>Nam, Jeong-Gu</creatorcontrib><creatorcontrib>Kim, Kisoon</creatorcontrib><creatorcontrib>Kim, Sung Soon</creatorcontrib><creatorcontrib>Kang, Hae Ji</creatorcontrib><title>Genetic characteristics of mumps viruses isolated in Korea from 2007 to 2012</title><title>Journal of medical virology</title><addtitle>J. Med. Virol</addtitle><description>Mumps is a vaccine‐preventable viral disease. Despite vaccine coverage of >95%, the incidence of mumps has increased in Korea since 2007. This study aimed to genetically characterize mumps virus (MuV) strains that circulated in Korea between 2007 and 2012 to determine the factors underlying mumps outbreaks. MuV was isolated from 175 clinical specimens between 2007 and 2012 in Korea. Upon analysis of the SH gene in Korean mumps virus isolates, three different genotypes were identified: I, H, and F. The MuV genotypes I and H co‐circulated in Korea, and eight isolates of Korean genotype F were found within the same time period in 2008. An analysis of HN amino‐acid sequence data showed that Korean isolates had no changes in their glycosylation sites. At putative neutralizing epitope sites, the Jeryl‐Lynn strain showed 4–5 different amino acid sequences from those observed in Korean isolates. Korean isolates of genotypes I and H shared distinctive point mutations on putative neutralizing epitope positions in each genotype. This report describes the genetic characteristics of MuV strains circulating in Korea and provides information on endemic mumps infections. This information may be important to help prevent mumps and control outbreaks of mumps in Korea. J. Med. Virol. 88:1479–1486, 2016. © 2016 Wiley Periodicals, Inc.</description><subject>Disease Outbreaks</subject><subject>Epitopes - immunology</subject><subject>genetic variability</subject><subject>Genetic Variation</subject><subject>Genotype</subject><subject>Genotype & phenotype</subject><subject>Humans</subject><subject>Mumps - epidemiology</subject><subject>Mumps - virology</subject><subject>Mumps virus</subject><subject>Mumps virus - classification</subject><subject>Mumps virus - genetics</subject><subject>Mumps virus - isolation & purification</subject><subject>Phylogeny</subject><subject>Republic of Korea - epidemiology</subject><subject>RNA, Viral - genetics</subject><subject>Sequence Alignment</subject><subject>Viral Proteins - genetics</subject><subject>Virology</subject><subject>Viruses</subject><issn>0146-6615</issn><issn>1096-9071</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkctOwzAQRS0EgvJY8APIEhtYpIzt2I6XqEChFNhAWVpu4oiUpC52wuPvMRRYICGxuhrpzJFmLkK7BPoEgB7Nmuc-TTnhK6hHQIlEgSSrqAckFYkQhG-gzRBmAJApStfRBhWKgxSyh8ZDO7dtleP8wXiTt9ZXIY4BuxI3XbMI-LnyXbABV8HVprUFrub40nlrcOldgymAxK2LSeg2WitNHezOV26hu7PT28F5Mr4ZXgyOx0meqpQnkivFeMlJQSFljHBZTGMQqkpjDMs4i9KsTJWyU8YZByIkWChMQQ03VLAtdLD0Lrx76mxodVOF3Na1mVvXBU0yyITIqKD_QalkMhUf1v1f6Mx1fh4P-aQAlJJppA6XVO5dCN6WeuGrxvg3TUB_tKFjG_qzjcjufRm7aWOLH_L7_RE4WgIvVW3f_jbp0dXkW5ksN2JN9vVnw_hHHX2S6_vroZ6MJnDCrwd6zN4BQFmeBA</recordid><startdate>201609</startdate><enddate>201609</enddate><creator>Kim, Seung Tae</creator><creator>Kim, You-Jin</creator><creator>Yang, Jeong-Sun</creator><creator>Nam, Jeong-Gu</creator><creator>Kim, Kisoon</creator><creator>Kim, Sung Soon</creator><creator>Kang, Hae Ji</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>201609</creationdate><title>Genetic characteristics of mumps viruses isolated in Korea from 2007 to 2012</title><author>Kim, Seung Tae ; Kim, You-Jin ; Yang, Jeong-Sun ; Nam, Jeong-Gu ; Kim, Kisoon ; Kim, Sung Soon ; Kang, Hae Ji</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4945-759935f51d20433157db331129faaa38532008f499eb353501670e0dad2a5a263</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Disease Outbreaks</topic><topic>Epitopes - immunology</topic><topic>genetic variability</topic><topic>Genetic Variation</topic><topic>Genotype</topic><topic>Genotype & phenotype</topic><topic>Humans</topic><topic>Mumps - epidemiology</topic><topic>Mumps - virology</topic><topic>Mumps virus</topic><topic>Mumps virus - classification</topic><topic>Mumps virus - genetics</topic><topic>Mumps virus - isolation & purification</topic><topic>Phylogeny</topic><topic>Republic of Korea - epidemiology</topic><topic>RNA, Viral - genetics</topic><topic>Sequence Alignment</topic><topic>Viral Proteins - genetics</topic><topic>Virology</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Seung Tae</creatorcontrib><creatorcontrib>Kim, You-Jin</creatorcontrib><creatorcontrib>Yang, Jeong-Sun</creatorcontrib><creatorcontrib>Nam, Jeong-Gu</creatorcontrib><creatorcontrib>Kim, Kisoon</creatorcontrib><creatorcontrib>Kim, Sung Soon</creatorcontrib><creatorcontrib>Kang, Hae Ji</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of medical virology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Seung Tae</au><au>Kim, You-Jin</au><au>Yang, Jeong-Sun</au><au>Nam, Jeong-Gu</au><au>Kim, Kisoon</au><au>Kim, Sung Soon</au><au>Kang, Hae Ji</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genetic characteristics of mumps viruses isolated in Korea from 2007 to 2012</atitle><jtitle>Journal of medical virology</jtitle><addtitle>J. Med. Virol</addtitle><date>2016-09</date><risdate>2016</risdate><volume>88</volume><issue>9</issue><spage>1479</spage><epage>1486</epage><pages>1479-1486</pages><issn>0146-6615</issn><eissn>1096-9071</eissn><abstract>Mumps is a vaccine‐preventable viral disease. Despite vaccine coverage of >95%, the incidence of mumps has increased in Korea since 2007. This study aimed to genetically characterize mumps virus (MuV) strains that circulated in Korea between 2007 and 2012 to determine the factors underlying mumps outbreaks. MuV was isolated from 175 clinical specimens between 2007 and 2012 in Korea. Upon analysis of the SH gene in Korean mumps virus isolates, three different genotypes were identified: I, H, and F. The MuV genotypes I and H co‐circulated in Korea, and eight isolates of Korean genotype F were found within the same time period in 2008. An analysis of HN amino‐acid sequence data showed that Korean isolates had no changes in their glycosylation sites. At putative neutralizing epitope sites, the Jeryl‐Lynn strain showed 4–5 different amino acid sequences from those observed in Korean isolates. Korean isolates of genotypes I and H shared distinctive point mutations on putative neutralizing epitope positions in each genotype. This report describes the genetic characteristics of MuV strains circulating in Korea and provides information on endemic mumps infections. This information may be important to help prevent mumps and control outbreaks of mumps in Korea. J. Med. Virol. 88:1479–1486, 2016. © 2016 Wiley Periodicals, Inc.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>26950767</pmid><doi>10.1002/jmv.24515</doi><tpages>8</tpages></addata></record> |
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| subjects | Disease Outbreaks Epitopes - immunology genetic variability Genetic Variation Genotype Genotype & phenotype Humans Mumps - epidemiology Mumps - virology Mumps virus Mumps virus - classification Mumps virus - genetics Mumps virus - isolation & purification Phylogeny Republic of Korea - epidemiology RNA, Viral - genetics Sequence Alignment Viral Proteins - genetics Virology Viruses |
| title | Genetic characteristics of mumps viruses isolated in Korea from 2007 to 2012 |
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