Using Automated Image Analysis Algorithms to Distinguish Normal, Aberrant, and Degenerate Mitotic Figures Induced by Eg5 Inhibition

Modulation of the cell cycle may underlie the toxicologic or pharmacologic responses of a potential therapeutic agent and contributes to decisions on its preclinical and clinical safety and efficacy. The descriptive and quantitative assessment of normal, aberrant, and degenerate mitotic figures in t...

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Veröffentlicht in:	Toxicologic pathology 2016-07, Vol.44 (5), p.663-672
Hauptverfasser:	Bigley, Alison L., Klein, Stephanie K., Davies, Barry, Williams, Leigh, Rudmann, Daniel G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Animals Antineoplastic Agents - pharmacology Carcinoma, Transitional Cell - pathology Cell Line, Tumor Humans Image Processing, Computer-Assisted - methods Kinesin - antagonists & inhibitors Mitosis - drug effects Rats Urinary Bladder Neoplasms - pathology Xenograft Model Antitumor Assays
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