Therapeutic antioxidant and anti-inflammatory effects of laser acupuncture on patients with rheumatoid arthritis
Background and Objective The laser acupuncture has many potential therapeutic effects. Currently, they are not evaluated for their therapeutic effects on rheumatoid arthritis (RA) patients. The aim of this study was to investigate the effects of laser acupuncture on the oxidative and antioxidative m...
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| Veröffentlicht in: | Lasers in surgery and medicine 2016-07, Vol.48 (5), p.490-497 |
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| creator | Attia, Atef M. M. Ibrahim, Fatma A. A. Abd El-Latif, Noha A. Aziz, Samir W. Elwan, Azhar M. Abdel Aziz, Abdel Aziz A. Elgendy, Aliaa Elgengehy, Fatema T. |
| description | Background and Objective
The laser acupuncture has many potential therapeutic effects. Currently, they are not evaluated for their therapeutic effects on rheumatoid arthritis (RA) patients. The aim of this study was to investigate the effects of laser acupuncture on the oxidative and antioxidative markers, as well as the inflammatory markers and disease activity of RA patients.
Design/Materials and Methods
The study was conducted on 30 RA patients and 20 healthy subjects. The patients were subjected to laser acupuncture (904 nm, 100 mW power output, 1 minute irradiation time, beam area of 1 cm2, total energy per point 6 J, energy density 6 J/ cm2, irradiance 0.1 W/cm2, frequency 10000 Hz, duty‐cycle 100%) for 3 days/week for duration of 4 weeks. The acupuncture points of exposure were LI4, TE5, LI 11, DU 14, LIV3, SP6, GB34, and S36. The levels of oxidative and antioxidant markers were determined by spectrophotometric methods whereas the inflammatory markers were determined by ELISA methods. Lastly, using DAS28 scores the disease activity was assessed.
Results
After laser acupuncture, the study group revealed significantly increased plasma superoxide dismutase (SOD), glutathione reductase (GR), catalase activities, blood glutathione (GSH), and plasma ATP concentrations, compared to those before treatment (P |
| doi_str_mv | 10.1002/lsm.22487 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_1808663052</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1808663052</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4957-cf1b9fa2618d181f04ce3a0c8f8e0a8c60e443259e5ade81aa8a3c635317ae23</originalsourceid><addsrcrecordid>eNqNkctO3EAQRVtRUJiQLPIDkaVssjF0u-1-LCPIAIqBRUbKslW0y5omfqUfgvn72DOERVas6pbq3JKqLiGfGD1llBZnXehPi6JU8g1ZMapFrhllb8mKslkrqotj8j6EB0opL6h8R44LoWQlhV6RabNFDxOm6GwGQ3Tjk2vmOutm3-duaDvoe4ij32XYtmhjyMY26yCgz8CmKQ02Jo_ZOGQTRIfDDDy6uM38FtNidPMqH7feRRc-kKMWuoAfn-sJ2ay_b86v8vru8vr8W53bUlcyty271y0UgqmGKdbS0iIHalWrkIKygmJZ8qLSWEGDigEo4FbwijMJWPAT8vWwdvLjn4Qhmt4Fi10HA44pGKaoEoLT6hWo1ErrSpcL-uU_9GFMfpjvWCipBavEQn1-ptJ9j42ZvOvB78y_r8_A2QF4dB3uXuaMmiVOM8dp9nGa-ufNXsyO_OBwIeLTiwP8byMkl5X5dXtp6tt6_YOtL0zJ_wImDaKg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1797961562</pqid></control><display><type>article</type><title>Therapeutic antioxidant and anti-inflammatory effects of laser acupuncture on patients with rheumatoid arthritis</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Attia, Atef M. M. ; Ibrahim, Fatma A. A. ; Abd El-Latif, Noha A. ; Aziz, Samir W. ; Elwan, Azhar M. ; Abdel Aziz, Abdel Aziz A. ; Elgendy, Aliaa ; Elgengehy, Fatema T.</creator><creatorcontrib>Attia, Atef M. M. ; Ibrahim, Fatma A. A. ; Abd El-Latif, Noha A. ; Aziz, Samir W. ; Elwan, Azhar M. ; Abdel Aziz, Abdel Aziz A. ; Elgendy, Aliaa ; Elgengehy, Fatema T.</creatorcontrib><description>Background and Objective
The laser acupuncture has many potential therapeutic effects. Currently, they are not evaluated for their therapeutic effects on rheumatoid arthritis (RA) patients. The aim of this study was to investigate the effects of laser acupuncture on the oxidative and antioxidative markers, as well as the inflammatory markers and disease activity of RA patients.
Design/Materials and Methods
The study was conducted on 30 RA patients and 20 healthy subjects. The patients were subjected to laser acupuncture (904 nm, 100 mW power output, 1 minute irradiation time, beam area of 1 cm2, total energy per point 6 J, energy density 6 J/ cm2, irradiance 0.1 W/cm2, frequency 10000 Hz, duty‐cycle 100%) for 3 days/week for duration of 4 weeks. The acupuncture points of exposure were LI4, TE5, LI 11, DU 14, LIV3, SP6, GB34, and S36. The levels of oxidative and antioxidant markers were determined by spectrophotometric methods whereas the inflammatory markers were determined by ELISA methods. Lastly, using DAS28 scores the disease activity was assessed.
Results
After laser acupuncture, the study group revealed significantly increased plasma superoxide dismutase (SOD), glutathione reductase (GR), catalase activities, blood glutathione (GSH), and plasma ATP concentrations, compared to those before treatment (P < 0.0005). Moreover, the results revealed significantly reduced plasma malondialdehyde (MDA), serum nitrate and nitrite, serum C‐reactive protein (CRP), plasma interleukin‐6 (IL‐6) levels and significantly reduced glutathione peroxidase (GPx) activity and erythrocyte sedimentation rate (ESR) in laser exposed patients, compared to those before treatment (P < 0.0005). The RA patients subjected to laser acupuncture showed highly significant reduction in disease activity (P < 0.0005) based on DAS28 score.
Conclusion
Our study results confirmed the effectiveness of laser acupuncture in alleviating oxidative stress and inflammation, improving antioxidant and energy metabolic status, while also suppressing the disease activity in RA patients. Laser acupuncture is a promising treatment modality to reduce the pain and suffering of RA patients because of its efficiency in inhibiting most of the main factors involved in the pathogenesis of this disease. Lasers Surg. Med. 48:490–497, 2016. © 2016 Wiley Periodicals, Inc.</description><identifier>ISSN: 0196-8092</identifier><identifier>EISSN: 1096-9101</identifier><identifier>DOI: 10.1002/lsm.22487</identifier><identifier>PMID: 26875769</identifier><identifier>CODEN: LSMEDI</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Acupuncture Therapy - methods ; Adult ; antioxidants ; Antioxidants - metabolism ; Arthritis, Rheumatoid - blood ; Arthritis, Rheumatoid - diagnosis ; Arthritis, Rheumatoid - therapy ; ATP ; Biomarkers - blood ; Case-Control Studies ; disease activity ; Enzyme-Linked Immunosorbent Assay ; Female ; Humans ; inflammation ; laser acupuncture ; Lasers, Semiconductor - therapeutic use ; Low-Level Light Therapy - methods ; Male ; Middle Aged ; Oxidative Stress ; rheumatoid arthritis ; Spectrophotometry ; Treatment Outcome</subject><ispartof>Lasers in surgery and medicine, 2016-07, Vol.48 (5), p.490-497</ispartof><rights>2016 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4957-cf1b9fa2618d181f04ce3a0c8f8e0a8c60e443259e5ade81aa8a3c635317ae23</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Flsm.22487$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Flsm.22487$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26875769$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Attia, Atef M. M.</creatorcontrib><creatorcontrib>Ibrahim, Fatma A. A.</creatorcontrib><creatorcontrib>Abd El-Latif, Noha A.</creatorcontrib><creatorcontrib>Aziz, Samir W.</creatorcontrib><creatorcontrib>Elwan, Azhar M.</creatorcontrib><creatorcontrib>Abdel Aziz, Abdel Aziz A.</creatorcontrib><creatorcontrib>Elgendy, Aliaa</creatorcontrib><creatorcontrib>Elgengehy, Fatema T.</creatorcontrib><title>Therapeutic antioxidant and anti-inflammatory effects of laser acupuncture on patients with rheumatoid arthritis</title><title>Lasers in surgery and medicine</title><addtitle>Lasers Surg. Med</addtitle><description>Background and Objective
The laser acupuncture has many potential therapeutic effects. Currently, they are not evaluated for their therapeutic effects on rheumatoid arthritis (RA) patients. The aim of this study was to investigate the effects of laser acupuncture on the oxidative and antioxidative markers, as well as the inflammatory markers and disease activity of RA patients.
Design/Materials and Methods
The study was conducted on 30 RA patients and 20 healthy subjects. The patients were subjected to laser acupuncture (904 nm, 100 mW power output, 1 minute irradiation time, beam area of 1 cm2, total energy per point 6 J, energy density 6 J/ cm2, irradiance 0.1 W/cm2, frequency 10000 Hz, duty‐cycle 100%) for 3 days/week for duration of 4 weeks. The acupuncture points of exposure were LI4, TE5, LI 11, DU 14, LIV3, SP6, GB34, and S36. The levels of oxidative and antioxidant markers were determined by spectrophotometric methods whereas the inflammatory markers were determined by ELISA methods. Lastly, using DAS28 scores the disease activity was assessed.
Results
After laser acupuncture, the study group revealed significantly increased plasma superoxide dismutase (SOD), glutathione reductase (GR), catalase activities, blood glutathione (GSH), and plasma ATP concentrations, compared to those before treatment (P < 0.0005). Moreover, the results revealed significantly reduced plasma malondialdehyde (MDA), serum nitrate and nitrite, serum C‐reactive protein (CRP), plasma interleukin‐6 (IL‐6) levels and significantly reduced glutathione peroxidase (GPx) activity and erythrocyte sedimentation rate (ESR) in laser exposed patients, compared to those before treatment (P < 0.0005). The RA patients subjected to laser acupuncture showed highly significant reduction in disease activity (P < 0.0005) based on DAS28 score.
Conclusion
Our study results confirmed the effectiveness of laser acupuncture in alleviating oxidative stress and inflammation, improving antioxidant and energy metabolic status, while also suppressing the disease activity in RA patients. Laser acupuncture is a promising treatment modality to reduce the pain and suffering of RA patients because of its efficiency in inhibiting most of the main factors involved in the pathogenesis of this disease. Lasers Surg. Med. 48:490–497, 2016. © 2016 Wiley Periodicals, Inc.</description><subject>Acupuncture Therapy - methods</subject><subject>Adult</subject><subject>antioxidants</subject><subject>Antioxidants - metabolism</subject><subject>Arthritis, Rheumatoid - blood</subject><subject>Arthritis, Rheumatoid - diagnosis</subject><subject>Arthritis, Rheumatoid - therapy</subject><subject>ATP</subject><subject>Biomarkers - blood</subject><subject>Case-Control Studies</subject><subject>disease activity</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Female</subject><subject>Humans</subject><subject>inflammation</subject><subject>laser acupuncture</subject><subject>Lasers, Semiconductor - therapeutic use</subject><subject>Low-Level Light Therapy - methods</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Oxidative Stress</subject><subject>rheumatoid arthritis</subject><subject>Spectrophotometry</subject><subject>Treatment Outcome</subject><issn>0196-8092</issn><issn>1096-9101</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkctO3EAQRVtRUJiQLPIDkaVssjF0u-1-LCPIAIqBRUbKslW0y5omfqUfgvn72DOERVas6pbq3JKqLiGfGD1llBZnXehPi6JU8g1ZMapFrhllb8mKslkrqotj8j6EB0opL6h8R44LoWQlhV6RabNFDxOm6GwGQ3Tjk2vmOutm3-duaDvoe4ij32XYtmhjyMY26yCgz8CmKQ02Jo_ZOGQTRIfDDDy6uM38FtNidPMqH7feRRc-kKMWuoAfn-sJ2ay_b86v8vru8vr8W53bUlcyty271y0UgqmGKdbS0iIHalWrkIKygmJZ8qLSWEGDigEo4FbwijMJWPAT8vWwdvLjn4Qhmt4Fi10HA44pGKaoEoLT6hWo1ErrSpcL-uU_9GFMfpjvWCipBavEQn1-ptJ9j42ZvOvB78y_r8_A2QF4dB3uXuaMmiVOM8dp9nGa-ufNXsyO_OBwIeLTiwP8byMkl5X5dXtp6tt6_YOtL0zJ_wImDaKg</recordid><startdate>201607</startdate><enddate>201607</enddate><creator>Attia, Atef M. M.</creator><creator>Ibrahim, Fatma A. A.</creator><creator>Abd El-Latif, Noha A.</creator><creator>Aziz, Samir W.</creator><creator>Elwan, Azhar M.</creator><creator>Abdel Aziz, Abdel Aziz A.</creator><creator>Elgendy, Aliaa</creator><creator>Elgengehy, Fatema T.</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>M7Z</scope><scope>P64</scope><scope>7X8</scope><scope>7QO</scope></search><sort><creationdate>201607</creationdate><title>Therapeutic antioxidant and anti-inflammatory effects of laser acupuncture on patients with rheumatoid arthritis</title><author>Attia, Atef M. M. ; Ibrahim, Fatma A. A. ; Abd El-Latif, Noha A. ; Aziz, Samir W. ; Elwan, Azhar M. ; Abdel Aziz, Abdel Aziz A. ; Elgendy, Aliaa ; Elgengehy, Fatema T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4957-cf1b9fa2618d181f04ce3a0c8f8e0a8c60e443259e5ade81aa8a3c635317ae23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Acupuncture Therapy - methods</topic><topic>Adult</topic><topic>antioxidants</topic><topic>Antioxidants - metabolism</topic><topic>Arthritis, Rheumatoid - blood</topic><topic>Arthritis, Rheumatoid - diagnosis</topic><topic>Arthritis, Rheumatoid - therapy</topic><topic>ATP</topic><topic>Biomarkers - blood</topic><topic>Case-Control Studies</topic><topic>disease activity</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Female</topic><topic>Humans</topic><topic>inflammation</topic><topic>laser acupuncture</topic><topic>Lasers, Semiconductor - therapeutic use</topic><topic>Low-Level Light Therapy - methods</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Oxidative Stress</topic><topic>rheumatoid arthritis</topic><topic>Spectrophotometry</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Attia, Atef M. M.</creatorcontrib><creatorcontrib>Ibrahim, Fatma A. A.</creatorcontrib><creatorcontrib>Abd El-Latif, Noha A.</creatorcontrib><creatorcontrib>Aziz, Samir W.</creatorcontrib><creatorcontrib>Elwan, Azhar M.</creatorcontrib><creatorcontrib>Abdel Aziz, Abdel Aziz A.</creatorcontrib><creatorcontrib>Elgendy, Aliaa</creatorcontrib><creatorcontrib>Elgengehy, Fatema T.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><jtitle>Lasers in surgery and medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Attia, Atef M. M.</au><au>Ibrahim, Fatma A. A.</au><au>Abd El-Latif, Noha A.</au><au>Aziz, Samir W.</au><au>Elwan, Azhar M.</au><au>Abdel Aziz, Abdel Aziz A.</au><au>Elgendy, Aliaa</au><au>Elgengehy, Fatema T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Therapeutic antioxidant and anti-inflammatory effects of laser acupuncture on patients with rheumatoid arthritis</atitle><jtitle>Lasers in surgery and medicine</jtitle><addtitle>Lasers Surg. Med</addtitle><date>2016-07</date><risdate>2016</risdate><volume>48</volume><issue>5</issue><spage>490</spage><epage>497</epage><pages>490-497</pages><issn>0196-8092</issn><eissn>1096-9101</eissn><coden>LSMEDI</coden><abstract>Background and Objective
The laser acupuncture has many potential therapeutic effects. Currently, they are not evaluated for their therapeutic effects on rheumatoid arthritis (RA) patients. The aim of this study was to investigate the effects of laser acupuncture on the oxidative and antioxidative markers, as well as the inflammatory markers and disease activity of RA patients.
Design/Materials and Methods
The study was conducted on 30 RA patients and 20 healthy subjects. The patients were subjected to laser acupuncture (904 nm, 100 mW power output, 1 minute irradiation time, beam area of 1 cm2, total energy per point 6 J, energy density 6 J/ cm2, irradiance 0.1 W/cm2, frequency 10000 Hz, duty‐cycle 100%) for 3 days/week for duration of 4 weeks. The acupuncture points of exposure were LI4, TE5, LI 11, DU 14, LIV3, SP6, GB34, and S36. The levels of oxidative and antioxidant markers were determined by spectrophotometric methods whereas the inflammatory markers were determined by ELISA methods. Lastly, using DAS28 scores the disease activity was assessed.
Results
After laser acupuncture, the study group revealed significantly increased plasma superoxide dismutase (SOD), glutathione reductase (GR), catalase activities, blood glutathione (GSH), and plasma ATP concentrations, compared to those before treatment (P < 0.0005). Moreover, the results revealed significantly reduced plasma malondialdehyde (MDA), serum nitrate and nitrite, serum C‐reactive protein (CRP), plasma interleukin‐6 (IL‐6) levels and significantly reduced glutathione peroxidase (GPx) activity and erythrocyte sedimentation rate (ESR) in laser exposed patients, compared to those before treatment (P < 0.0005). The RA patients subjected to laser acupuncture showed highly significant reduction in disease activity (P < 0.0005) based on DAS28 score.
Conclusion
Our study results confirmed the effectiveness of laser acupuncture in alleviating oxidative stress and inflammation, improving antioxidant and energy metabolic status, while also suppressing the disease activity in RA patients. Laser acupuncture is a promising treatment modality to reduce the pain and suffering of RA patients because of its efficiency in inhibiting most of the main factors involved in the pathogenesis of this disease. Lasers Surg. Med. 48:490–497, 2016. © 2016 Wiley Periodicals, Inc.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>26875769</pmid><doi>10.1002/lsm.22487</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Acupuncture Therapy - methods Adult antioxidants Antioxidants - metabolism Arthritis, Rheumatoid - blood Arthritis, Rheumatoid - diagnosis Arthritis, Rheumatoid - therapy ATP Biomarkers - blood Case-Control Studies disease activity Enzyme-Linked Immunosorbent Assay Female Humans inflammation laser acupuncture Lasers, Semiconductor - therapeutic use Low-Level Light Therapy - methods Male Middle Aged Oxidative Stress rheumatoid arthritis Spectrophotometry Treatment Outcome |
| title | Therapeutic antioxidant and anti-inflammatory effects of laser acupuncture on patients with rheumatoid arthritis |
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