Genetic variations involved in sudden cardiac death and their associations and interactions
Although the mechanism of sudden cardiac death (SCD) in heart failure is not completely known, genetic variations are known to play key roles in this process. Increasing numbers of mutations and variants are being discovered through genome-wide association studies. The genetic variations involved in...
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| Veröffentlicht in: | Heart failure reviews 2016-07, Vol.21 (4), p.401-414 |
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| creator | Wei, Dazhen Tao, Luyuan Huang, Mingyuan |
| description | Although the mechanism of sudden cardiac death (SCD) in heart failure is not completely known, genetic variations are known to play key roles in this process. Increasing numbers of mutations and variants are being discovered through genome-wide association studies. The genetic variations involved in the mechanisms of SCD have aroused widespread concern. Comprehensive understanding of the genetic variations involved in SCD may help prevent it. To this end, we briefly reviewed the genetic variations involved in SCD and their associations and interactions, and observed that cardiac ion channels are the core molecules involved in this process. Genetic variations involved in cardiac structure, cardiogenesis and development, cell division and differentiation, and DNA replication and transcription are all speculated to be loci involved in SCD. Additionally, the systems involved in neurohumoral regulation as well as substance and energy metabolism are also potentially responsible for susceptibility to SCD. They form an elaborate network and mutually interact with each other to govern the fate of SCD-susceptible individuals. |
| doi_str_mv | 10.1007/s10741-016-9563-6 |
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They form an elaborate network and mutually interact with each other to govern the fate of SCD-susceptible individuals.</description><subject>Cardiology</subject><subject>Death, Sudden, Cardiac - etiology</subject><subject>Genetic Variation</subject><subject>Genome-Wide Association Study</subject><subject>Heart Failure - complications</subject><subject>Heart Failure - genetics</subject><subject>Humans</subject><subject>Ion Channels - metabolism</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mutation</subject><issn>1382-4147</issn><issn>1573-7322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkc9rFTEQx4NYbH36B3iRBS9e1s4k2fw4StEqFLy0Jw8hm8zalPeyNdl94H9vnq8VEQRPM0w-3--Q-TL2CuEdAujziqAl9oCqt4MSvXrCznDQoteC86etF4b3EqU-Zc9rvQMAaSU8Y6dcc4lohzP29ZIyLSl0e1-SX9Kca5fyft7uKbamq2uMlLvgS0w-dJH8ctv5HLvlllLpfK1zeNQdxikvVHz4NXjBTia_rfTyoW7YzccP1xef-qsvl58v3l_1QcKw9JMWPo4oSHlv7ehJTFKTDAbNSDhF4zWNfDIhGgKPMIIkGJSVaBVKK8SGvT363pf5-0p1cbtUA223PtO8VocGjFLcqv9AtbUczKCgoW_-Qu_mteT2kQNlFEfRTr1heKRCmWstNLn7kna-_HAI7hCSO4bkWkjuEJJTTfP6wXkddxR_Kx5TaQA_ArU95W9U_lj9T9efAN6clw</recordid><startdate>20160701</startdate><enddate>20160701</enddate><creator>Wei, Dazhen</creator><creator>Tao, Luyuan</creator><creator>Huang, Mingyuan</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20160701</creationdate><title>Genetic variations involved in sudden cardiac death and their associations and interactions</title><author>Wei, Dazhen ; Tao, Luyuan ; Huang, Mingyuan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c405t-f73adb13e6aa99bae3f47e4c818be1fd8a7eb2f8cd8e0a10b04e0569419614933</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Cardiology</topic><topic>Death, Sudden, Cardiac - etiology</topic><topic>Genetic Variation</topic><topic>Genome-Wide Association Study</topic><topic>Heart Failure - complications</topic><topic>Heart Failure - genetics</topic><topic>Humans</topic><topic>Ion Channels - metabolism</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mutation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wei, Dazhen</creatorcontrib><creatorcontrib>Tao, Luyuan</creatorcontrib><creatorcontrib>Huang, Mingyuan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Heart failure reviews</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wei, Dazhen</au><au>Tao, Luyuan</au><au>Huang, Mingyuan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genetic variations involved in sudden cardiac death and their associations and interactions</atitle><jtitle>Heart failure reviews</jtitle><stitle>Heart Fail Rev</stitle><addtitle>Heart Fail Rev</addtitle><date>2016-07-01</date><risdate>2016</risdate><volume>21</volume><issue>4</issue><spage>401</spage><epage>414</epage><pages>401-414</pages><issn>1382-4147</issn><eissn>1573-7322</eissn><coden>HFREFC</coden><abstract>Although the mechanism of sudden cardiac death (SCD) in heart failure is not completely known, genetic variations are known to play key roles in this process. Increasing numbers of mutations and variants are being discovered through genome-wide association studies. The genetic variations involved in the mechanisms of SCD have aroused widespread concern. Comprehensive understanding of the genetic variations involved in SCD may help prevent it. To this end, we briefly reviewed the genetic variations involved in SCD and their associations and interactions, and observed that cardiac ion channels are the core molecules involved in this process. Genetic variations involved in cardiac structure, cardiogenesis and development, cell division and differentiation, and DNA replication and transcription are all speculated to be loci involved in SCD. Additionally, the systems involved in neurohumoral regulation as well as substance and energy metabolism are also potentially responsible for susceptibility to SCD. 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| subjects | Cardiology Death, Sudden, Cardiac - etiology Genetic Variation Genome-Wide Association Study Heart Failure - complications Heart Failure - genetics Humans Ion Channels - metabolism Medicine Medicine & Public Health Mutation |
| title | Genetic variations involved in sudden cardiac death and their associations and interactions |
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