Detection of BCR-ABL gene mutations in chronic myeloid leukemia using biochips

A biochip-based method was developed to identify the BCR-ABL mutations that affect the thyrosine kinase domain and determine resistance to targeted therapy with thyrosine kinase inhibitors. The method is based on RT–PCR followed by allele-specific hybridization on a biochip with immobilized oligonuc...

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Veröffentlicht in:	Molecular biology (New York) 2016-05, Vol.50 (3), p.412-416
Hauptverfasser:	Ikonnikova, A. Yu, Yatsenko, Yu. E., Kremenetskaya, O. S., Vinogradova, O. V., Fesenko, D. O., Abramov, I. S., Ovsepyan, V. A., Nasedkina, T. V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry Biomedical and Life Sciences Human Genetics Hybridization Leukemia Life Sciences Molecular biology Molecular Cell Biology Mutation Polymerase chain reaction
Online-Zugang:	Volltext
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