β-Bungarotoxin is a potent inducer of apoptosis in cultured rat neurons by receptor-mediated internalization

The neurotoxic phospholipase A2, β‐bungarotoxin (β‐BuTx), is a component of the snake venom from the Taiwanese banded krait Bungarus multicinctus. β‐BuTx affects presynaptic nerve terminal function of the neuromuscular junction and induces widespread neuronal cell death throughout the mammalian and...

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Veröffentlicht in:	The European journal of neuroscience 2001-09, Vol.14 (5), p.821-828
Hauptverfasser:	Herkert, Matthias, Shakhman, Olena, Schweins, Elisabeth, Becker, Cord-Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Annexin A5 - analysis annexin-V Apoptosis - drug effects Bungarotoxins - pharmacokinetics Bungarus multicinctus Calpain - antagonists & inhibitors Calpain - metabolism Caspase Inhibitors Caspases - metabolism Cells, Cultured Cysteine Proteinase Inhibitors - pharmacology Dipeptides - pharmacology Dose-Response Relationship, Drug Elapid Venoms - pharmacology Female hippocampal neuron Hippocampus - cytology In Situ Nick-End Labeling Neurons - chemistry Neurons - cytology Neurons - metabolism Neurotoxins - pharmacology phospholipase A2 Phospholipases A - metabolism Pregnancy primary culture rat Rats Rats, Wistar Receptors, Cell Surface - metabolism Signal Transduction - physiology TUNEL
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