Autoantibody pathogenicity in a multifocal motor neuropathy induced pluripotent stem cell-derived model

Objective We investigated the pathogenicity of immunoglobulin M (IgM) anti‐GM1 antibodies in serum from patients with multifocal motor neuropathy (MMN) using human induced pluripotent stem cell (iPSC)‐derived motor neurons (MNs). Methods iPSCs were generated from fibroblasts and differentiated into...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Annals of neurology 2016-07, Vol.80 (1), p.71-88
Hauptverfasser:	Harschnitz, Oliver, van den Berg, Leonard H., Johansen, Lill Eva, Jansen, Marc D., Kling, Sandra, Vieira de Sá, Renata, Vlam, Lotte, van Rheenen, Wouter, Karst, Henk, Wierenga, Corette J., Pasterkamp, R. Jeroen, van der Pol, W. Ludo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Autoantibodies - blood Autoantibodies - immunology Autoantibodies - metabolism Calcium - metabolism Case-Control Studies Coculture Techniques Female G(M1) Ganglioside - immunology G(M1) Ganglioside - metabolism Humans Immunoglobulin M - immunology Immunoglobulin M - metabolism Immunoglobulins Induced Pluripotent Stem Cells Male Middle Aged Motor Neurons - immunology Motor Neurons - metabolism Motor Neurons - pathology Motor Neurons - ultrastructure Neurites - pathology Polyneuropathies - blood Polyneuropathies - immunology Polyneuropathies - metabolism Polyneuropathies - pathology Protein Binding - immunology Stem cells
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!