Mitotic quiescence, but not unique “stemness,” marks the phenotype of bone metastasis‐initiating cells in prostate cancer

This study aimed to identify subpopulations of prostate cancer cells that are responsible for the initiation of bone metastases. Using rapidly dividing human prostate cancer cell lines, we identified mitotically quiescent subpopulations (

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Bibliographische Detailangaben
Veröffentlicht in:	The FASEB journal 2015-08, Vol.29 (8), p.3141-3150
Hauptverfasser:	Wang, Ning, Docherty, Freyja, Brown, Hannah K., Reeves, Kim, Fowles, Anne, Lawson, Michelle, Ottewell, Penelope D., Holen, Ingunn, Croucher, Peter I., Eaton, Colby L.
Format:	Artikel
Sprache:	eng
Schlagworte:	AC133 Antigen Animals Antigens, CD - metabolism Biomarkers, Tumor - metabolism Bone Neoplasms - metabolism Bone Neoplasms - pathology cell quiescence CXCR4 Glycoproteins - metabolism Humans Hyaluronan Receptors - metabolism Integrin alpha Chains - metabolism Integrin beta Chains - metabolism Male metastatic niche Mice Mice, Inbred BALB C Mice, Nude Mitosis - physiology Neoplastic Stem Cells - metabolism Neoplastic Stem Cells - pathology Peptides - metabolism Phenotype Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology Receptors, CXCR4 - metabolism Tumor Cells, Cultured
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Beschreibung
Zusammenfassung:	This study aimed to identify subpopulations of prostate cancer cells that are responsible for the initiation of bone metastases. Using rapidly dividing human prostate cancer cell lines, we identified mitotically quiescent subpopulations (
ISSN:	0892-6638 1530-6860
DOI:	10.1096/fj.14-266379