Chondroitin sulfate activates B cells in vitro, expands CD138+ cells in vivo, and interferes with established humoral immune responses

Chondroitin sulfate activates B cells in a BTK‐ and Syk‐dependent manner, and suppresses established humoral immune responses by interfering with antigen specific plasma cells. Glycosaminoglycans have anti‐inflammatory properties and interact with a variety of soluble and membrane‐bound molecules. L...

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Veröffentlicht in:	Journal of leukocyte biology 2014-07, Vol.96 (1), p.65-72
Hauptverfasser:	Brühl, Hilke, Cihak, Josef, Goebel, Nicole, Talke, Yvonne, Renner, Kerstin, Hermann, Fabian, Rodriguez‐Gomez, Manuel, Reich, Barbara, Plachý, Jîŕi, Stangassinger, Manfred, Mack, Matthias
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bone Marrow Cells - immunology Cell Movement - drug effects Cell Movement - immunology Cell Proliferation - drug effects Chondroitin Sulfates - pharmacology collagen‐induced arthritis glycosaminoglycans Hyaluronan Receptors - genetics Hyaluronan Receptors - immunology Immunity, Humoral - drug effects Immunity, Humoral - genetics Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - immunology Lymphocyte Activation - drug effects Lymphocyte Activation - genetics Mice Mice, Inbred BALB C Mice, Knockout plasma cells Plasma Cells - immunology Protein-Tyrosine Kinases - genetics Protein-Tyrosine Kinases - immunology Syk Kinase Syndecan-1 - genetics Syndecan-1 - immunology Toll-Like Receptor 4 - genetics Toll-Like Receptor 4 - immunology Toll-Like Receptor 9 - genetics Toll-Like Receptor 9 - immunology
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