Caspase-1 activation by NLRP3 inflammasome dampens IL-33-dependent house dust mite-induced allergic lung inflammation

The cysteine protease caspase-1 (Casp-1) contributes to innate immunity through the assembly of NLRP3, NLRC4, AIM2, and NLRP6 inflammasomes. Here we ask whether caspase-1 activation plays a regulatory role in house dust mite (HDM)-induced experimental allergic airway inflammation. We report enhanced...

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Veröffentlicht in:	Journal of molecular cell biology 2015-08, Vol.7 (4), p.351-365
Hauptverfasser:	Madouri, Fahima, Guillou, Noëlline, Fauconnier, Louis, Marchiol, Tiffany, Rouxel, Nathalie, Chenuet, Pauline, Ledru, Aurélie, Apetoh, Lionel, Ghiringhelli, François, Chamaillard, Mathias, Zheng, Song Guo, Trovero, Fabrice, Quesniaux, Valérie F J, Ryffel, Bernhard, Togbe, Dieudonnée
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Intranasal Animals Antigens, Dermatophagoides - immunology Apoptosis Regulatory Proteins - metabolism Calcium-Binding Proteins - metabolism Carrier Proteins - metabolism Caspase 1 - deficiency Caspase 1 - metabolism Dermatophagoides pteronyssinus Disease Models, Animal Enzyme Activation - drug effects Hypersensitivity - enzymology Hypersensitivity - immunology Hypersensitivity - parasitology Immunity - drug effects Inflammasomes - metabolism Inflammation - complications Inflammation - immunology Inflammation - pathology Interleukin-33 - immunology Lung - enzymology Lung - immunology Lung - parasitology Lung - pathology Macrophages - drug effects Macrophages - metabolism Mice, Inbred C57BL NLR Family, Pyrin Domain-Containing 3 Protein Pyroglyphidae - immunology Recombinant Fusion Proteins - pharmacology Th2 Cells - drug effects Th2 Cells - immunology Uric Acid - metabolism
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