The effects of ciprofloxacin on early life stages of common carp (Cyprinus carpio)

The authors performed a toxicity test with ciprofloxacin in fertilized eggs of common carp according to guideline 210 of the Organisation for Economic Co‐operation and Development. The tested concentrations were 1 μg L−1, 100 μg L−1, 500 μg L−1, 1000 μg L−1, and 3000 μg L−1. Accelerated hatching was found in all groups exposed to ciprofloxacin, but significant growth reduction was found only in the group exposed to the highest concentration (3000 μg L−1). Increased numbers of macroscopic morphological anomalies were observed on day 6 of the test (after hatching). The highest numbers of macroscopic morphological anomalies were observed in the groups of free embryos and larvae exposed to ciprofloxacin concentrations of 100 μg L−1, 500 μg L−1, 1000 μg L−1, and 3000 μg L−1 (20−23% of tested samples). A gradual decrease in glutathione S‐transferase activity was detected in all experimental groups exposed to ciprofloxacin, but significant differences (p