Mutation frequencies in HIV-1 subtype-A genome in regions containing efficient RNAi targets

The development of gene-therapy technology using RNAi for AIDS/HIV-1 treatment is a prospective alternative to traditional anti-retroviral therapy. RNAi targets could be selected in HIV-1 transcripts and in CCR5 mRNA. Previously, we experimentally selected a number of efficient siRNAs that target HI...

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Veröffentlicht in:	Molecular biology (New York) 2016-05, Vol.50 (3), p.417-421
Hauptverfasser:	Kravatsky, Y. V., Chechetkin, V. R., Fedoseeva, D. M., Gorbacheva, M. A., Kretova, O. V., Tchurikov, N. A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Pairing Biochemistry Biomedical and Life Sciences Codon Gene therapy Genome, Viral Genotype HIV HIV Infections - therapy HIV Infections - virology HIV-1 - genetics HIV-1 - metabolism Human Genetics Human immunodeficiency virus Human immunodeficiency virus 1 Humans Lentivirus Life Sciences Molecular biology Molecular Cell Biology Molecular Targeted Therapy Mutation Mutation Rate Ribonucleic acid RNA RNA Interference RNA, Small Interfering - genetics RNA, Small Interfering - metabolism RNA, Viral - antagonists & inhibitors RNA, Viral - genetics RNA, Viral - metabolism Russia Transcription factors
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