A lentiviral vector-based therapeutic vaccine encoding Ag85B-Rv3425 potently increases resistance to acute tuberculosis infection in mice

Few treatment options for multidrug-resistant tuberculosis （TB） and extensively drug-resistant TB call attention to the development of novel therapeutic approaches for TB. Therapeutic vaccines are promising candidates because they can induce antigen-specific cellular immune responses, which play an...

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Veröffentlicht in:	Acta biochimica et biophysica Sinica 2015-08, Vol.47 (8), p.588-596
Hauptverfasser:	Yang, Enzhuo, Wang, Feifei, Xu, Ying, Wang, Honghai, Hu, Yong, Shen, Hongbo, Chen, Zheng W
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Acyltransferases - immunology Adaptive Immunity Animals Antigens, Bacterial - immunology Bacterial Proteins - immunology Genetic Vectors Immunotherapy, Active Lentivirus Mice Mycobacterium tuberculosis Tuberculosis - immunology Tuberculosis - prevention & control Tuberculosis Vaccines - administration & dosage Tuberculosis Vaccines - immunology 小鼠急性感染慢病毒载体抗原特异性治疗性病毒疫苗结核分枝杆菌结核病
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