Assessing the impact of a joint human-porcine intervention package for Taenia solium control: Results of a pilot study from northern Lao PDR
•Taenia solium taeniasis prevalence was significantly reduced during the project lifetime.•First T. solium control intervention in Southeast Asia targeting both pigs and humans.•First demonstration globally of the impact of joint anthelmintic therapy on the adult T. solium parasite in human host.•Th...
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| Veröffentlicht in: | Acta tropica 2016-07, Vol.159, p.185-191 |
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| creator | Okello, Anna L. Thomas, Lian Inthavong, Phouth Ash, Amanda Khamlome, Boualam Keokamphet, Chattouphone Newberry, Kim Gauci, Charles G. Gabriël, Sarah Dorny, Pierre Thompson, RC Andrew Lightowlers, Marshall W. Allen, John |
| description | •Taenia solium taeniasis prevalence was significantly reduced during the project lifetime.•First T. solium control intervention in Southeast Asia targeting both pigs and humans.•First demonstration globally of the impact of joint anthelmintic therapy on the adult T. solium parasite in human host.•These results are a timely contribution to the WHO Neglected Tropical Disease Roadmap.
Following confirmation that a remote village of approximately 300 inhabitants in northern Lao PDR was hyperendemic for the Neglected Tropical Disease Taenia solium, a pilot human-porcine therapeutic control intervention was implemented between October 2013 and November 2014. Mass drug administration with a three day albendazole 400mg protocol was offered to all eligible humans in October 2013 and March 2014. At these times, and again in October 2014, eligible village pigs received the anti-cysticercosis TSOL18 vaccination and an oral dose of oxfendazole anthelmintic at 30mg/kg, both repeated one month later. Community and individual human taeniasis prevalences were estimated via copro-antigen ELISA of volunteered human faecal samples prior to October 2013, and again in January 2015, in order to examine the short term impact of the intervention. |
| doi_str_mv | 10.1016/j.actatropica.2016.03.012 |
| format | Article |
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Following confirmation that a remote village of approximately 300 inhabitants in northern Lao PDR was hyperendemic for the Neglected Tropical Disease Taenia solium, a pilot human-porcine therapeutic control intervention was implemented between October 2013 and November 2014. Mass drug administration with a three day albendazole 400mg protocol was offered to all eligible humans in October 2013 and March 2014. At these times, and again in October 2014, eligible village pigs received the anti-cysticercosis TSOL18 vaccination and an oral dose of oxfendazole anthelmintic at 30mg/kg, both repeated one month later. Community and individual human taeniasis prevalences were estimated via copro-antigen ELISA of volunteered human faecal samples prior to October 2013, and again in January 2015, in order to examine the short term impact of the intervention.</description><identifier>ISSN: 0001-706X</identifier><identifier>EISSN: 1873-6254</identifier><identifier>DOI: 10.1016/j.actatropica.2016.03.012</identifier><identifier>PMID: 26992295</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Albendazole - therapeutic use ; Animals ; Anthelmintics - therapeutic use ; Benzimidazoles - therapeutic use ; Cysticercosis - drug therapy ; Cysticercosis - epidemiology ; Cysticercosis - prevention & control ; Enzyme-Linked Immunosorbent Assay ; Feces - parasitology ; Female ; Humans ; Laos - epidemiology ; Male ; Middle Aged ; Pilot Projects ; Prevalence ; Swine ; Swine Diseases - drug therapy ; Swine Diseases - epidemiology ; Swine Diseases - parasitology ; Taenia solium ; Taenia solium - isolation & purification ; Taeniasis - drug therapy ; Taeniasis - prevention & control ; Vaccination</subject><ispartof>Acta tropica, 2016-07, Vol.159, p.185-191</ispartof><rights>2016 The Authors</rights><rights>Copyright © 2016 The Authors. Published by Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c461t-6b0cf453188210c59c021779137da0e8a03e2edd2106cc562d7fc72a4dc1271e3</citedby><cites>FETCH-LOGICAL-c461t-6b0cf453188210c59c021779137da0e8a03e2edd2106cc562d7fc72a4dc1271e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0001706X16301024$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26992295$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Okello, Anna L.</creatorcontrib><creatorcontrib>Thomas, Lian</creatorcontrib><creatorcontrib>Inthavong, Phouth</creatorcontrib><creatorcontrib>Ash, Amanda</creatorcontrib><creatorcontrib>Khamlome, Boualam</creatorcontrib><creatorcontrib>Keokamphet, Chattouphone</creatorcontrib><creatorcontrib>Newberry, Kim</creatorcontrib><creatorcontrib>Gauci, Charles G.</creatorcontrib><creatorcontrib>Gabriël, Sarah</creatorcontrib><creatorcontrib>Dorny, Pierre</creatorcontrib><creatorcontrib>Thompson, RC Andrew</creatorcontrib><creatorcontrib>Lightowlers, Marshall W.</creatorcontrib><creatorcontrib>Allen, John</creatorcontrib><title>Assessing the impact of a joint human-porcine intervention package for Taenia solium control: Results of a pilot study from northern Lao PDR</title><title>Acta tropica</title><addtitle>Acta Trop</addtitle><description>•Taenia solium taeniasis prevalence was significantly reduced during the project lifetime.•First T. solium control intervention in Southeast Asia targeting both pigs and humans.•First demonstration globally of the impact of joint anthelmintic therapy on the adult T. solium parasite in human host.•These results are a timely contribution to the WHO Neglected Tropical Disease Roadmap.
Following confirmation that a remote village of approximately 300 inhabitants in northern Lao PDR was hyperendemic for the Neglected Tropical Disease Taenia solium, a pilot human-porcine therapeutic control intervention was implemented between October 2013 and November 2014. Mass drug administration with a three day albendazole 400mg protocol was offered to all eligible humans in October 2013 and March 2014. At these times, and again in October 2014, eligible village pigs received the anti-cysticercosis TSOL18 vaccination and an oral dose of oxfendazole anthelmintic at 30mg/kg, both repeated one month later. Community and individual human taeniasis prevalences were estimated via copro-antigen ELISA of volunteered human faecal samples prior to October 2013, and again in January 2015, in order to examine the short term impact of the intervention.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Albendazole - therapeutic use</subject><subject>Animals</subject><subject>Anthelmintics - therapeutic use</subject><subject>Benzimidazoles - therapeutic use</subject><subject>Cysticercosis - drug therapy</subject><subject>Cysticercosis - epidemiology</subject><subject>Cysticercosis - prevention & control</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Feces - parasitology</subject><subject>Female</subject><subject>Humans</subject><subject>Laos - epidemiology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Pilot Projects</subject><subject>Prevalence</subject><subject>Swine</subject><subject>Swine Diseases - drug therapy</subject><subject>Swine Diseases - epidemiology</subject><subject>Swine Diseases - parasitology</subject><subject>Taenia solium</subject><subject>Taenia solium - isolation & purification</subject><subject>Taeniasis - drug therapy</subject><subject>Taeniasis - prevention & control</subject><subject>Vaccination</subject><issn>0001-706X</issn><issn>1873-6254</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc1u1TAQhS0EopfCK6BhxybBdhI7YVfd8iddiapqJXaWa09aXxI72E6lvgMPjatbELt2NfLMN-dYcwh5x2jNKBMf9rU2WecYFmd0zUurpk1NGX9GNqyXTSV41z4nG0opqyQVP47Iq5T25cVlx1-SIy6GgfOh25DfJylhSs5fQ75BcPNSpCGMoGEfnM9ws87aV0uIxvky9xnjLfrsgoeC_tTXCGOIcKHROw0pTG6dwQRffjd9hHNM65TTQXBxU8iQ8mrvYIxhBh9iMY0edjrA2en5a_Ji1FPCNw_1mFx-_nSx_Vrtvn_5tj3ZVaYVLFfiipqx7RrW95xR0w2GciblwBppNcVe0wY5WluGwphOcCtHI7lurSkHYNgck_cH3SWGXyumrGaXDE6T9hjWpFhPe9G1vBGPo7If2qFlHS_ocEBNDClFHNUS3azjnWJU3eem9uq_3NR9boo2qqRSdt8-2KxXM9p_m3-DKsD2AGC5y63DqJJx6A1aF9FkZYN7gs0fV5uwuw</recordid><startdate>201607</startdate><enddate>201607</enddate><creator>Okello, Anna L.</creator><creator>Thomas, Lian</creator><creator>Inthavong, Phouth</creator><creator>Ash, Amanda</creator><creator>Khamlome, Boualam</creator><creator>Keokamphet, Chattouphone</creator><creator>Newberry, Kim</creator><creator>Gauci, Charles G.</creator><creator>Gabriël, Sarah</creator><creator>Dorny, Pierre</creator><creator>Thompson, RC Andrew</creator><creator>Lightowlers, Marshall W.</creator><creator>Allen, John</creator><general>Elsevier B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>C1K</scope><scope>F1W</scope><scope>H95</scope><scope>H97</scope><scope>L.G</scope><scope>M7N</scope></search><sort><creationdate>201607</creationdate><title>Assessing the impact of a joint human-porcine intervention package for Taenia solium control: Results of a pilot study from northern Lao PDR</title><author>Okello, Anna L. ; Thomas, Lian ; Inthavong, Phouth ; Ash, Amanda ; Khamlome, Boualam ; Keokamphet, Chattouphone ; Newberry, Kim ; Gauci, Charles G. ; Gabriël, Sarah ; Dorny, Pierre ; Thompson, RC Andrew ; Lightowlers, Marshall W. ; Allen, John</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c461t-6b0cf453188210c59c021779137da0e8a03e2edd2106cc562d7fc72a4dc1271e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Albendazole - therapeutic use</topic><topic>Animals</topic><topic>Anthelmintics - therapeutic use</topic><topic>Benzimidazoles - therapeutic use</topic><topic>Cysticercosis - drug therapy</topic><topic>Cysticercosis - epidemiology</topic><topic>Cysticercosis - prevention & control</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Feces - parasitology</topic><topic>Female</topic><topic>Humans</topic><topic>Laos - epidemiology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Pilot Projects</topic><topic>Prevalence</topic><topic>Swine</topic><topic>Swine Diseases - drug therapy</topic><topic>Swine Diseases - epidemiology</topic><topic>Swine Diseases - parasitology</topic><topic>Taenia solium</topic><topic>Taenia solium - isolation & purification</topic><topic>Taeniasis - drug therapy</topic><topic>Taeniasis - prevention & control</topic><topic>Vaccination</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Okello, Anna L.</creatorcontrib><creatorcontrib>Thomas, Lian</creatorcontrib><creatorcontrib>Inthavong, Phouth</creatorcontrib><creatorcontrib>Ash, Amanda</creatorcontrib><creatorcontrib>Khamlome, Boualam</creatorcontrib><creatorcontrib>Keokamphet, Chattouphone</creatorcontrib><creatorcontrib>Newberry, Kim</creatorcontrib><creatorcontrib>Gauci, Charles G.</creatorcontrib><creatorcontrib>Gabriël, Sarah</creatorcontrib><creatorcontrib>Dorny, Pierre</creatorcontrib><creatorcontrib>Thompson, RC Andrew</creatorcontrib><creatorcontrib>Lightowlers, Marshall W.</creatorcontrib><creatorcontrib>Allen, John</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><jtitle>Acta tropica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Okello, Anna L.</au><au>Thomas, Lian</au><au>Inthavong, Phouth</au><au>Ash, Amanda</au><au>Khamlome, Boualam</au><au>Keokamphet, Chattouphone</au><au>Newberry, Kim</au><au>Gauci, Charles G.</au><au>Gabriël, Sarah</au><au>Dorny, Pierre</au><au>Thompson, RC Andrew</au><au>Lightowlers, Marshall W.</au><au>Allen, John</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Assessing the impact of a joint human-porcine intervention package for Taenia solium control: Results of a pilot study from northern Lao PDR</atitle><jtitle>Acta tropica</jtitle><addtitle>Acta Trop</addtitle><date>2016-07</date><risdate>2016</risdate><volume>159</volume><spage>185</spage><epage>191</epage><pages>185-191</pages><issn>0001-706X</issn><eissn>1873-6254</eissn><abstract>•Taenia solium taeniasis prevalence was significantly reduced during the project lifetime.•First T. solium control intervention in Southeast Asia targeting both pigs and humans.•First demonstration globally of the impact of joint anthelmintic therapy on the adult T. solium parasite in human host.•These results are a timely contribution to the WHO Neglected Tropical Disease Roadmap.
Following confirmation that a remote village of approximately 300 inhabitants in northern Lao PDR was hyperendemic for the Neglected Tropical Disease Taenia solium, a pilot human-porcine therapeutic control intervention was implemented between October 2013 and November 2014. Mass drug administration with a three day albendazole 400mg protocol was offered to all eligible humans in October 2013 and March 2014. At these times, and again in October 2014, eligible village pigs received the anti-cysticercosis TSOL18 vaccination and an oral dose of oxfendazole anthelmintic at 30mg/kg, both repeated one month later. Community and individual human taeniasis prevalences were estimated via copro-antigen ELISA of volunteered human faecal samples prior to October 2013, and again in January 2015, in order to examine the short term impact of the intervention.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>26992295</pmid><doi>10.1016/j.actatropica.2016.03.012</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Acta tropica, 2016-07, Vol.159, p.185-191 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Aged Aged, 80 and over Albendazole - therapeutic use Animals Anthelmintics - therapeutic use Benzimidazoles - therapeutic use Cysticercosis - drug therapy Cysticercosis - epidemiology Cysticercosis - prevention & control Enzyme-Linked Immunosorbent Assay Feces - parasitology Female Humans Laos - epidemiology Male Middle Aged Pilot Projects Prevalence Swine Swine Diseases - drug therapy Swine Diseases - epidemiology Swine Diseases - parasitology Taenia solium Taenia solium - isolation & purification Taeniasis - drug therapy Taeniasis - prevention & control Vaccination |
| title | Assessing the impact of a joint human-porcine intervention package for Taenia solium control: Results of a pilot study from northern Lao PDR |
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