Leukocyte‐associated Ig‐like receptor‐1 is a novel inhibitory receptor for surfactant protein D
Inhibitory LAIR‐1 as a novel receptor for SP‐D, and may mediate immunomodulatory effects of SP‐D. The collagenous C‐type lectin, SP‐D, is a multitrimeric glycoprotein present at mucosal surfaces and is involved in host defense against infections in mammals. SP‐D has immunomodulatory properties, but...
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| Veröffentlicht in: | Journal of leukocyte biology 2014-07, Vol.96 (1), p.105-111 |
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| container_title | Journal of leukocyte biology |
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| creator | Olde Nordkamp, Marloes J. M. Eijk, Martin Urbanus, Rolf T. Bont, Louis Haagsman, Henk P. Meyaard, Linde |
| description | Inhibitory LAIR‐1 as a novel receptor for SP‐D, and may mediate immunomodulatory effects of SP‐D.
The collagenous C‐type lectin, SP‐D, is a multitrimeric glycoprotein present at mucosal surfaces and is involved in host defense against infections in mammals. SP‐D has immunomodulatory properties, but the underlying mechanisms are incompletely understood. SP‐D contains collagen domains. LAIR‐1 is an inhibitory immune receptor at the cell surface of various immune‐competent cells that binds collagen. We hypothesized that the immunomodulatory functions of SP‐D can be mediated via interactions between its collagen domain and LAIR‐1. Binding assays show that SP‐D interacts via its collagenous domain with LAIR‐1 and the related LAIR‐2. This does not affect the mannan‐binding capacities of SP‐D, which induces cross‐linking of LAIR‐1 in a cellular reporter assay. Functional assays show that SP‐D inhibits the production of FcαR‐mediated reactive oxygen via LAIR‐1. Our studies indicate that SP‐D is a functional ligand of the immune inhibitory receptor LAIR‐1. Thus, we have identified a novel pathway for the immunomodulatory functions of SP‐D mediated via binding of its collagenous domains to LAIR‐1. This may provide a mechanism for the unexplained immunomodulatory function of the collagenous domains of SP‐D. |
| doi_str_mv | 10.1189/jlb.3AB0213-092RR |
| format | Article |
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The collagenous C‐type lectin, SP‐D, is a multitrimeric glycoprotein present at mucosal surfaces and is involved in host defense against infections in mammals. SP‐D has immunomodulatory properties, but the underlying mechanisms are incompletely understood. SP‐D contains collagen domains. LAIR‐1 is an inhibitory immune receptor at the cell surface of various immune‐competent cells that binds collagen. We hypothesized that the immunomodulatory functions of SP‐D can be mediated via interactions between its collagen domain and LAIR‐1. Binding assays show that SP‐D interacts via its collagenous domain with LAIR‐1 and the related LAIR‐2. This does not affect the mannan‐binding capacities of SP‐D, which induces cross‐linking of LAIR‐1 in a cellular reporter assay. Functional assays show that SP‐D inhibits the production of FcαR‐mediated reactive oxygen via LAIR‐1. Our studies indicate that SP‐D is a functional ligand of the immune inhibitory receptor LAIR‐1. Thus, we have identified a novel pathway for the immunomodulatory functions of SP‐D mediated via binding of its collagenous domains to LAIR‐1. This may provide a mechanism for the unexplained immunomodulatory function of the collagenous domains of SP‐D.</description><identifier>ISSN: 0741-5400</identifier><identifier>EISSN: 1938-3673</identifier><identifier>DOI: 10.1189/jlb.3AB0213-092RR</identifier><identifier>PMID: 24585933</identifier><language>eng</language><publisher>United States</publisher><subject>Antigens, CD - genetics ; Antigens, CD - immunology ; Antigens, CD - metabolism ; collectin ; HL-60 Cells ; Humans ; immunomodulatory ; inhibitory immune receptor ; LAIR‐1 ; Protein Binding ; Protein Structure, Tertiary ; Pulmonary Surfactant-Associated Protein D - genetics ; Pulmonary Surfactant-Associated Protein D - immunology ; Pulmonary Surfactant-Associated Protein D - metabolism ; Receptors, Fc - genetics ; Receptors, Fc - immunology ; Receptors, Fc - metabolism ; Receptors, Immunologic - agonists ; Receptors, Immunologic - genetics ; Receptors, Immunologic - immunology ; Receptors, Immunologic - metabolism</subject><ispartof>Journal of leukocyte biology, 2014-07, Vol.96 (1), p.105-111</ispartof><rights>2014 Society for Leukocyte Biology</rights><rights>2014 Society for Leukocyte Biology.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4905-5be1b961c1c6416714ba29cfbc0c1738562ad4eebe6cd7ddebc2bfac7ef6b8953</citedby><cites>FETCH-LOGICAL-c4905-5be1b961c1c6416714ba29cfbc0c1738562ad4eebe6cd7ddebc2bfac7ef6b8953</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1189%2Fjlb.3AB0213-092RR$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1189%2Fjlb.3AB0213-092RR$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24585933$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Olde Nordkamp, Marloes J. M.</creatorcontrib><creatorcontrib>Eijk, Martin</creatorcontrib><creatorcontrib>Urbanus, Rolf T.</creatorcontrib><creatorcontrib>Bont, Louis</creatorcontrib><creatorcontrib>Haagsman, Henk P.</creatorcontrib><creatorcontrib>Meyaard, Linde</creatorcontrib><title>Leukocyte‐associated Ig‐like receptor‐1 is a novel inhibitory receptor for surfactant protein D</title><title>Journal of leukocyte biology</title><addtitle>J Leukoc Biol</addtitle><description>Inhibitory LAIR‐1 as a novel receptor for SP‐D, and may mediate immunomodulatory effects of SP‐D.
The collagenous C‐type lectin, SP‐D, is a multitrimeric glycoprotein present at mucosal surfaces and is involved in host defense against infections in mammals. SP‐D has immunomodulatory properties, but the underlying mechanisms are incompletely understood. SP‐D contains collagen domains. LAIR‐1 is an inhibitory immune receptor at the cell surface of various immune‐competent cells that binds collagen. We hypothesized that the immunomodulatory functions of SP‐D can be mediated via interactions between its collagen domain and LAIR‐1. Binding assays show that SP‐D interacts via its collagenous domain with LAIR‐1 and the related LAIR‐2. This does not affect the mannan‐binding capacities of SP‐D, which induces cross‐linking of LAIR‐1 in a cellular reporter assay. Functional assays show that SP‐D inhibits the production of FcαR‐mediated reactive oxygen via LAIR‐1. Our studies indicate that SP‐D is a functional ligand of the immune inhibitory receptor LAIR‐1. Thus, we have identified a novel pathway for the immunomodulatory functions of SP‐D mediated via binding of its collagenous domains to LAIR‐1. This may provide a mechanism for the unexplained immunomodulatory function of the collagenous domains of SP‐D.</description><subject>Antigens, CD - genetics</subject><subject>Antigens, CD - immunology</subject><subject>Antigens, CD - metabolism</subject><subject>collectin</subject><subject>HL-60 Cells</subject><subject>Humans</subject><subject>immunomodulatory</subject><subject>inhibitory immune receptor</subject><subject>LAIR‐1</subject><subject>Protein Binding</subject><subject>Protein Structure, Tertiary</subject><subject>Pulmonary Surfactant-Associated Protein D - genetics</subject><subject>Pulmonary Surfactant-Associated Protein D - immunology</subject><subject>Pulmonary Surfactant-Associated Protein D - metabolism</subject><subject>Receptors, Fc - genetics</subject><subject>Receptors, Fc - immunology</subject><subject>Receptors, Fc - metabolism</subject><subject>Receptors, Immunologic - agonists</subject><subject>Receptors, Immunologic - genetics</subject><subject>Receptors, Immunologic - immunology</subject><subject>Receptors, Immunologic - metabolism</subject><issn>0741-5400</issn><issn>1938-3673</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1OHDEQhS0UBMPPAbKJvMymict_bS-BJIRoJCQEa8t2VxNDT_ek3Z1odjlCzpiTxGQmbFmUSqX66j2pHiFvgZ0BGPvhsQtn4vyCcRAVs_z2do8swApTCV2LN2TBagmVkowdkqOcHxljgmt2QA65VEZZIRYElzg_DXEz4Z9fv33OQ0x-woZeP5S5S09IR4y4noaxzEBTpp72ww_saOq_pZDKYvOC0LZUnsfWx8n3E12Pw4Sppx9PyH7ru4ynu35M7j9_urv8Ui1vrq4vz5dVlJapSgWEYDVEiFqCrkEGz21sQ2QRamGU5r6RiAF1bOqmwRB5KGY1tjoYq8Qxeb_VLc7fZ8yTW6Ucset8j8OcHRhmtBK2tq-jSnJujZF1QWGLxnHIecTWrce08uPGAXPPQbgShNsF4f4FUW7e7eTnsMLm5eL_5wugt8DP1OHmdUX3dXnBgCnxF5nZmgg</recordid><startdate>201407</startdate><enddate>201407</enddate><creator>Olde Nordkamp, Marloes J. M.</creator><creator>Eijk, Martin</creator><creator>Urbanus, Rolf T.</creator><creator>Bont, Louis</creator><creator>Haagsman, Henk P.</creator><creator>Meyaard, Linde</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>201407</creationdate><title>Leukocyte‐associated Ig‐like receptor‐1 is a novel inhibitory receptor for surfactant protein D</title><author>Olde Nordkamp, Marloes J. 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M.</creatorcontrib><creatorcontrib>Eijk, Martin</creatorcontrib><creatorcontrib>Urbanus, Rolf T.</creatorcontrib><creatorcontrib>Bont, Louis</creatorcontrib><creatorcontrib>Haagsman, Henk P.</creatorcontrib><creatorcontrib>Meyaard, Linde</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Journal of leukocyte biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Olde Nordkamp, Marloes J. 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The collagenous C‐type lectin, SP‐D, is a multitrimeric glycoprotein present at mucosal surfaces and is involved in host defense against infections in mammals. SP‐D has immunomodulatory properties, but the underlying mechanisms are incompletely understood. SP‐D contains collagen domains. LAIR‐1 is an inhibitory immune receptor at the cell surface of various immune‐competent cells that binds collagen. We hypothesized that the immunomodulatory functions of SP‐D can be mediated via interactions between its collagen domain and LAIR‐1. Binding assays show that SP‐D interacts via its collagenous domain with LAIR‐1 and the related LAIR‐2. This does not affect the mannan‐binding capacities of SP‐D, which induces cross‐linking of LAIR‐1 in a cellular reporter assay. Functional assays show that SP‐D inhibits the production of FcαR‐mediated reactive oxygen via LAIR‐1. Our studies indicate that SP‐D is a functional ligand of the immune inhibitory receptor LAIR‐1. Thus, we have identified a novel pathway for the immunomodulatory functions of SP‐D mediated via binding of its collagenous domains to LAIR‐1. This may provide a mechanism for the unexplained immunomodulatory function of the collagenous domains of SP‐D.</abstract><cop>United States</cop><pmid>24585933</pmid><doi>10.1189/jlb.3AB0213-092RR</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | Wiley Online Library - AutoHoldings Journals; MEDLINE; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Antigens, CD - genetics Antigens, CD - immunology Antigens, CD - metabolism collectin HL-60 Cells Humans immunomodulatory inhibitory immune receptor LAIR‐1 Protein Binding Protein Structure, Tertiary Pulmonary Surfactant-Associated Protein D - genetics Pulmonary Surfactant-Associated Protein D - immunology Pulmonary Surfactant-Associated Protein D - metabolism Receptors, Fc - genetics Receptors, Fc - immunology Receptors, Fc - metabolism Receptors, Immunologic - agonists Receptors, Immunologic - genetics Receptors, Immunologic - immunology Receptors, Immunologic - metabolism |
| title | Leukocyte‐associated Ig‐like receptor‐1 is a novel inhibitory receptor for surfactant protein D |
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