Combining bosentan and sildenafil in pulmonary arterial hypertension patients failing monotherapy: real-world insights

Pulmonary arterial hypertension is a severe disease with a complex pathogenesis, for which combination therapy is an attractive option.This study aimed to assess the impact of sequential combination therapy on both short-term responses and long-term outcomes in a real-world setting.Patients with idi...

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Veröffentlicht in:	The European respiratory journal 2015-08, Vol.46 (2), p.414-421
Hauptverfasser:	Dardi, Fabio, Manes, Alessandra, Palazzini, Massimiliano, Bachetti, Cristina, Mazzanti, Gaia, Rinaldi, Andrea, Albini, Alessandra, Gotti, Enrico, Monti, Enrico, Bacchi Reggiani, Maria Letizia, Galiè, Nazzareno
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aged, 80 and over Antihypertensive Agents - administration & dosage Antihypertensive Agents - therapeutic use Cause of Death Child Connective Tissue Diseases - complications Drug Therapy, Combination Exercise Test Familial Primary Pulmonary Hypertension - complications Female Heart Defects, Congenital - complications Hemodynamics - drug effects Humans Hypertension, Pulmonary - complications Hypertension, Pulmonary - drug therapy Hypertension, Pulmonary - mortality Italy Kaplan-Meier Estimate Male Middle Aged Retrospective Studies Sildenafil Citrate - administration & dosage Sildenafil Citrate - therapeutic use Sulfonamides - administration & dosage Sulfonamides - therapeutic use Survival Rate Treatment Outcome Vasodilator Agents - administration & dosage Vasodilator Agents - therapeutic use Young Adult
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