Auraptene induces oligodendrocyte lineage precursor cells in a cuprizone-induced animal model of demyelination
Abstract We investigated the effects of auraptene on mouse oligodendroglial cell lineage in an animal model of demyelination induced by cuprizone. Auraptene, a citrus coumarin, was intraperitoneally administered to mice fed the demyelinating agent cuprizone. Immunohistochemical analysis of the corpu...
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| Veröffentlicht in: | Brain research 2016-05, Vol.1639, p.28-37 |
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| creator | Nakajima, Mitsunari Shimizu, Risei Furuta, Kohei Sugino, Mami Watanabe, Takashi Aoki, Rui Okuyama, Satoshi Furukawa, Yoshiko |
| description | Abstract We investigated the effects of auraptene on mouse oligodendroglial cell lineage in an animal model of demyelination induced by cuprizone. Auraptene, a citrus coumarin, was intraperitoneally administered to mice fed the demyelinating agent cuprizone. Immunohistochemical analysis of the corpus callosum and/or Western blotting analysis of brain extracts revealed that cuprizone reduced immunoreactivity for myelin-basic protein, a marker of myelin, whereas it increased immunoreactivity to platelet derived-growth factor receptor-α, a marker of oligodendrocyte precursor cells. Administration of auraptene enhanced the immunoreactivity to oligodendrocyte transcription factor 2, a marker of oligodendrocyte precursor cells and oligodendrocyte lineage precursor cells, but had no effect on immunoreactivity to myelin-basic protein or platelet-derived growth factor receptor-α. These findings suggest that auraptene promotes the production of oligodendrocyte lineage precursor cells in an animal model of demyelination and may be useful for individuals with demyelinating diseases. |
| doi_str_mv | 10.1016/j.brainres.2016.02.041 |
| format | Article |
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Auraptene, a citrus coumarin, was intraperitoneally administered to mice fed the demyelinating agent cuprizone. Immunohistochemical analysis of the corpus callosum and/or Western blotting analysis of brain extracts revealed that cuprizone reduced immunoreactivity for myelin-basic protein, a marker of myelin, whereas it increased immunoreactivity to platelet derived-growth factor receptor-α, a marker of oligodendrocyte precursor cells. Administration of auraptene enhanced the immunoreactivity to oligodendrocyte transcription factor 2, a marker of oligodendrocyte precursor cells and oligodendrocyte lineage precursor cells, but had no effect on immunoreactivity to myelin-basic protein or platelet-derived growth factor receptor-α. These findings suggest that auraptene promotes the production of oligodendrocyte lineage precursor cells in an animal model of demyelination and may be useful for individuals with demyelinating diseases.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/j.brainres.2016.02.041</identifier><identifier>PMID: 26944297</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Animals ; Auraptene ; Basic Helix-Loop-Helix Transcription Factors - metabolism ; Brain - drug effects ; Brain - metabolism ; Brain - pathology ; Citrus ; Coumarins - pharmacology ; Cuprizone ; Demyelinating Diseases - drug therapy ; Demyelinating Diseases - metabolism ; Demyelinating Diseases - pathology ; Demyelination ; Disease Models, Animal ; Drug Evaluation, Preclinical ; Gene Expression - drug effects ; Injections, Intraperitoneal ; Male ; Mice, 129 Strain ; Mice, Inbred C57BL ; Microglia - drug effects ; Microglia - metabolism ; Myelin Basic Protein - metabolism ; Nerve Tissue Proteins - metabolism ; Neurology ; Neuroprotective Agents - pharmacology ; Olig2 ; Oligodendrocyte precursor cell (OPC) ; Oligodendrocyte Transcription Factor 2 ; Oligodendroglia - drug effects ; Oligodendroglia - metabolism ; Oligodendroglia - pathology ; PLP/DM-20 ; Receptor, Platelet-Derived Growth Factor alpha - metabolism ; Stem Cells - drug effects ; Stem Cells - physiology</subject><ispartof>Brain research, 2016-05, Vol.1639, p.28-37</ispartof><rights>2016 Elsevier B.V.</rights><rights>Copyright © 2016 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c456t-371a768120d9908c56d8a33990b06cd9d11cfe4b94111d938bc5319de65462e23</citedby><cites>FETCH-LOGICAL-c456t-371a768120d9908c56d8a33990b06cd9d11cfe4b94111d938bc5319de65462e23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0006899316301007$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26944297$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nakajima, Mitsunari</creatorcontrib><creatorcontrib>Shimizu, Risei</creatorcontrib><creatorcontrib>Furuta, Kohei</creatorcontrib><creatorcontrib>Sugino, Mami</creatorcontrib><creatorcontrib>Watanabe, Takashi</creatorcontrib><creatorcontrib>Aoki, Rui</creatorcontrib><creatorcontrib>Okuyama, Satoshi</creatorcontrib><creatorcontrib>Furukawa, Yoshiko</creatorcontrib><title>Auraptene induces oligodendrocyte lineage precursor cells in a cuprizone-induced animal model of demyelination</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>Abstract We investigated the effects of auraptene on mouse oligodendroglial cell lineage in an animal model of demyelination induced by cuprizone. Auraptene, a citrus coumarin, was intraperitoneally administered to mice fed the demyelinating agent cuprizone. Immunohistochemical analysis of the corpus callosum and/or Western blotting analysis of brain extracts revealed that cuprizone reduced immunoreactivity for myelin-basic protein, a marker of myelin, whereas it increased immunoreactivity to platelet derived-growth factor receptor-α, a marker of oligodendrocyte precursor cells. Administration of auraptene enhanced the immunoreactivity to oligodendrocyte transcription factor 2, a marker of oligodendrocyte precursor cells and oligodendrocyte lineage precursor cells, but had no effect on immunoreactivity to myelin-basic protein or platelet-derived growth factor receptor-α. These findings suggest that auraptene promotes the production of oligodendrocyte lineage precursor cells in an animal model of demyelination and may be useful for individuals with demyelinating diseases.</description><subject>Animals</subject><subject>Auraptene</subject><subject>Basic Helix-Loop-Helix Transcription Factors - metabolism</subject><subject>Brain - drug effects</subject><subject>Brain - metabolism</subject><subject>Brain - pathology</subject><subject>Citrus</subject><subject>Coumarins - pharmacology</subject><subject>Cuprizone</subject><subject>Demyelinating Diseases - drug therapy</subject><subject>Demyelinating Diseases - metabolism</subject><subject>Demyelinating Diseases - pathology</subject><subject>Demyelination</subject><subject>Disease Models, Animal</subject><subject>Drug Evaluation, Preclinical</subject><subject>Gene Expression - drug effects</subject><subject>Injections, Intraperitoneal</subject><subject>Male</subject><subject>Mice, 129 Strain</subject><subject>Mice, Inbred C57BL</subject><subject>Microglia - drug effects</subject><subject>Microglia - metabolism</subject><subject>Myelin Basic Protein - metabolism</subject><subject>Nerve Tissue Proteins - metabolism</subject><subject>Neurology</subject><subject>Neuroprotective Agents - pharmacology</subject><subject>Olig2</subject><subject>Oligodendrocyte precursor cell (OPC)</subject><subject>Oligodendrocyte Transcription Factor 2</subject><subject>Oligodendroglia - drug effects</subject><subject>Oligodendroglia - metabolism</subject><subject>Oligodendroglia - pathology</subject><subject>PLP/DM-20</subject><subject>Receptor, Platelet-Derived Growth Factor alpha - metabolism</subject><subject>Stem Cells - drug effects</subject><subject>Stem Cells - physiology</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUk1v1DAQtRCILoW_UPnIJWFsJ459QVRV-ZAqcQDOlmPPVl4Se7ETpOXX42hbDlx6Go303puZ94aQKwYtAybfHdox2xAzlpbXvgXeQseekR1TA28k7-A52QGAbJTW4oK8KuVQWyE0vCQXXOqu43rYkXi9ZntcMCIN0a8OC01TuE8eo8_JnRakU4ho75EeM7o1l5Spw2kqFU8tdesxhz8pYnOme2pjmO1E5yox0bSnHucTVg27hBRfkxd7OxV881AvyY-Pt99vPjd3Xz99ubm-a1zXy6URA7ODVIyD1xqU66VXtu6uYQTpvPaMuT12o-4YY14LNbpeMO1R9p3kyMUleXvWPeb0a8WymDmUbW0bMa3FMAVK9kz08DR0UHro9SA3VXmGupxKybg39fjZ5pNhYLZYzME8xmK2WAxwU2OpxKuHGes4o_9He8yhAj6cAVhN-R0wm-ICxupnqK4vxqfw9Iz3_0m46npwdvqJJyyHtOZYLTfMlEow37bn2H6DSQEMYBB_AZE6t4c</recordid><startdate>20160515</startdate><enddate>20160515</enddate><creator>Nakajima, Mitsunari</creator><creator>Shimizu, Risei</creator><creator>Furuta, Kohei</creator><creator>Sugino, Mami</creator><creator>Watanabe, Takashi</creator><creator>Aoki, Rui</creator><creator>Okuyama, Satoshi</creator><creator>Furukawa, Yoshiko</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope></search><sort><creationdate>20160515</creationdate><title>Auraptene induces oligodendrocyte lineage precursor cells in a cuprizone-induced animal model of demyelination</title><author>Nakajima, Mitsunari ; Shimizu, Risei ; Furuta, Kohei ; Sugino, Mami ; Watanabe, Takashi ; Aoki, Rui ; Okuyama, Satoshi ; Furukawa, Yoshiko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c456t-371a768120d9908c56d8a33990b06cd9d11cfe4b94111d938bc5319de65462e23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Animals</topic><topic>Auraptene</topic><topic>Basic Helix-Loop-Helix Transcription Factors - metabolism</topic><topic>Brain - drug effects</topic><topic>Brain - metabolism</topic><topic>Brain - pathology</topic><topic>Citrus</topic><topic>Coumarins - pharmacology</topic><topic>Cuprizone</topic><topic>Demyelinating Diseases - drug therapy</topic><topic>Demyelinating Diseases - metabolism</topic><topic>Demyelinating Diseases - pathology</topic><topic>Demyelination</topic><topic>Disease Models, Animal</topic><topic>Drug Evaluation, Preclinical</topic><topic>Gene Expression - drug effects</topic><topic>Injections, Intraperitoneal</topic><topic>Male</topic><topic>Mice, 129 Strain</topic><topic>Mice, Inbred C57BL</topic><topic>Microglia - drug effects</topic><topic>Microglia - metabolism</topic><topic>Myelin Basic Protein - metabolism</topic><topic>Nerve Tissue Proteins - metabolism</topic><topic>Neurology</topic><topic>Neuroprotective Agents - pharmacology</topic><topic>Olig2</topic><topic>Oligodendrocyte precursor cell (OPC)</topic><topic>Oligodendrocyte Transcription Factor 2</topic><topic>Oligodendroglia - drug effects</topic><topic>Oligodendroglia - metabolism</topic><topic>Oligodendroglia - pathology</topic><topic>PLP/DM-20</topic><topic>Receptor, Platelet-Derived Growth Factor alpha - metabolism</topic><topic>Stem Cells - drug effects</topic><topic>Stem Cells - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nakajima, Mitsunari</creatorcontrib><creatorcontrib>Shimizu, Risei</creatorcontrib><creatorcontrib>Furuta, Kohei</creatorcontrib><creatorcontrib>Sugino, Mami</creatorcontrib><creatorcontrib>Watanabe, Takashi</creatorcontrib><creatorcontrib>Aoki, Rui</creatorcontrib><creatorcontrib>Okuyama, Satoshi</creatorcontrib><creatorcontrib>Furukawa, Yoshiko</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nakajima, Mitsunari</au><au>Shimizu, Risei</au><au>Furuta, Kohei</au><au>Sugino, Mami</au><au>Watanabe, Takashi</au><au>Aoki, Rui</au><au>Okuyama, Satoshi</au><au>Furukawa, Yoshiko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Auraptene induces oligodendrocyte lineage precursor cells in a cuprizone-induced animal model of demyelination</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>2016-05-15</date><risdate>2016</risdate><volume>1639</volume><spage>28</spage><epage>37</epage><pages>28-37</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><abstract>Abstract We investigated the effects of auraptene on mouse oligodendroglial cell lineage in an animal model of demyelination induced by cuprizone. Auraptene, a citrus coumarin, was intraperitoneally administered to mice fed the demyelinating agent cuprizone. Immunohistochemical analysis of the corpus callosum and/or Western blotting analysis of brain extracts revealed that cuprizone reduced immunoreactivity for myelin-basic protein, a marker of myelin, whereas it increased immunoreactivity to platelet derived-growth factor receptor-α, a marker of oligodendrocyte precursor cells. Administration of auraptene enhanced the immunoreactivity to oligodendrocyte transcription factor 2, a marker of oligodendrocyte precursor cells and oligodendrocyte lineage precursor cells, but had no effect on immunoreactivity to myelin-basic protein or platelet-derived growth factor receptor-α. These findings suggest that auraptene promotes the production of oligodendrocyte lineage precursor cells in an animal model of demyelination and may be useful for individuals with demyelinating diseases.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>26944297</pmid><doi>10.1016/j.brainres.2016.02.041</doi><tpages>10</tpages></addata></record> |
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| subjects | Animals Auraptene Basic Helix-Loop-Helix Transcription Factors - metabolism Brain - drug effects Brain - metabolism Brain - pathology Citrus Coumarins - pharmacology Cuprizone Demyelinating Diseases - drug therapy Demyelinating Diseases - metabolism Demyelinating Diseases - pathology Demyelination Disease Models, Animal Drug Evaluation, Preclinical Gene Expression - drug effects Injections, Intraperitoneal Male Mice, 129 Strain Mice, Inbred C57BL Microglia - drug effects Microglia - metabolism Myelin Basic Protein - metabolism Nerve Tissue Proteins - metabolism Neurology Neuroprotective Agents - pharmacology Olig2 Oligodendrocyte precursor cell (OPC) Oligodendrocyte Transcription Factor 2 Oligodendroglia - drug effects Oligodendroglia - metabolism Oligodendroglia - pathology PLP/DM-20 Receptor, Platelet-Derived Growth Factor alpha - metabolism Stem Cells - drug effects Stem Cells - physiology |
| title | Auraptene induces oligodendrocyte lineage precursor cells in a cuprizone-induced animal model of demyelination |
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