Neurotoxicity screening of (illicit) drugs using novel methods for analysis of microelectrode array (MEA) recordings

•Rat cortical cultures consist of astrocytes, glutamatergic and GABAergic neurons.•Neuronal activity in cortical cultures can be measured using mwMEA.•The analysis strategy applied should detect transient effects on neuronal activity.•Activity is affected by exposure to neurotransmitters, like GABA...

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Veröffentlicht in:	Neurotoxicology (Park Forest South) 2016-07, Vol.55, p.1-9
Hauptverfasser:	Hondebrink, L., Verboven, A.H.A., Drega, W.S., Schmeink, S., de Groot, M.W.G.D.M., van Kleef, R.G.D.M., Wijnolts, F.M.J., de Groot, A., Meulenbelt, J., Westerink, R.H.S.
Format:	Artikel
Sprache:	eng
Schlagworte:	6-Cyano-7-nitroquinoxaline-2,3-dione - pharmacology Action Potentials - drug effects Analysis strategy Animals Animals, Newborn Astrocytes - drug effects Cerebral Cortex - cytology Characterisation Dizocilpine Maleate - pharmacology Drug Evaluation, Preclinical - methods Excitatory Amino Acid Antagonists - pharmacology GABA Agents - pharmacology GABA Plasma Membrane Transport Proteins - metabolism Glial Fibrillary Acidic Protein - metabolism Illicit drugs Integrated testing strategy Microelectrodes Neurons - drug effects Neurotoxicity screening Rats Rats, Wistar Street Drugs - toxicity Time Factors Tyrosine 3-Monooxygenase - metabolism Vesicular Glutamate Transport Protein 1 - metabolism
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