The hippocampus: a special place for time

Many findings have demonstrated that memories of past events are temporally organized. It is well known that the hippocampus is critical for such episodic memories, but, until recently, little was known about the temporal organization of mnemonic representations in the hippocampus. Recent developmen...

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Veröffentlicht in:Annals of the New York Academy of Sciences 2016-04, Vol.1369 (1), p.93-110
Hauptverfasser: Ranganath, Charan, Hsieh, Liang-Tien
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Hsieh, Liang-Tien
description Many findings have demonstrated that memories of past events are temporally organized. It is well known that the hippocampus is critical for such episodic memories, but, until recently, little was known about the temporal organization of mnemonic representations in the hippocampus. Recent developments in human and animal research have revealed important insights into the role of the hippocampus in learning and retrieving sequences of events. Here, we review these findings, including lesion and single‐unit recording studies in rodents, functional magnetic resonance imaging studies in humans, and computational models that link findings from these studies to the anatomy of the hippocampal circuit. The findings converge toward the idea that the hippocampus is essential for learning sequences of events, allowing the brain to distinguish between memories for conceptually similar but temporally distinct episodes, and to associate representations of temporally contiguous, but otherwise unrelated experiences.
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source Wiley-Blackwell Journals; MEDLINE
subjects Animals
episodic
hippocampus
Hippocampus - diagnostic imaging
Hippocampus - physiology
Humans
Learning - physiology
Magnetic Resonance Imaging
memory
Memory, Episodic
Models, Neurological
Nerve Net - diagnostic imaging
Nerve Net - physiology
Rodentia
sequence
time
Time Perception - physiology
title The hippocampus: a special place for time
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