PrEP Adherence Patterns Strongly Affect Individual HIV Risk and Observed Efficacy in Randomized Clinical Trials

BACKGROUND:Randomized controlled trials (RCTs) suggest that the efficacy of tenofovir-based preexposure prophylaxis (PrEP) strongly depends on the consistency of PrEP use. We explore how the patterns of pill taking and waning of PrEP protection may affect PrEP efficacy for HIV prevention. METHODS:A...

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Veröffentlicht in:	Journal of acquired immune deficiency syndromes (1999) 2016-08, Vol.72 (4), p.444-451
Hauptverfasser:	Dimitrov, Dobromir T, Mâsse, Benoît R, Donnell, Deborah
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Antiretroviral drugs Female HIV HIV Infections - prevention & control HIV Infections - transmission Human immunodeficiency virus Humans Male Mathematical models Medication Adherence - statistics & numerical data Models, Biological Pre-Exposure Prophylaxis Randomized Controlled Trials as Topic Risk assessment Sexual Partners Simulation Tenofovir - administration & dosage Tenofovir - therapeutic use Treatment Outcome
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