Does gastroesophageal reflux increase chronic obstructive pulmonary disease exacerbations?
Abstract Background The relationship between chronic obstructive pulmonary disease (COPD) exacerbations and gastroesophageal reflux (GER) has been investigated less than asthma-GER. We aimed to evaluate the presence of GER in patients with COPD and its impact on exacerbations. Methods We included 24...
Gespeichert in:
| Veröffentlicht in: | Respiratory medicine 2016-06, Vol.115, p.20-25 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 25 |
|---|---|
| container_issue | |
| container_start_page | 20 |
| container_title | Respiratory medicine |
| container_volume | 115 |
| creator | Iliaz, Sinem Iliaz, Raim Onur, Seda Tural Arici, Serpil Akyuz, Umit Karaca, Cetin Demir, Kadir Besisik, Fatih Kaymakoglu, Sabahattin Akyuz, Filiz |
| description | Abstract Background The relationship between chronic obstructive pulmonary disease (COPD) exacerbations and gastroesophageal reflux (GER) has been investigated less than asthma-GER. We aimed to evaluate the presence of GER in patients with COPD and its impact on exacerbations. Methods We included 24 patients with stable mild-moderate stage COPD and 19 volunteers as the control group. We conducted a gastroesophageal reflux disease (GERD) symptom questionnaire, gastroscopy, manometry, and an ambulatory 24-h pH-impedance study. Results According to the GERD questionnaire, only 5 (20.8%) patients with COPD had typical GER symptoms. According to the 24-h pH-impedance study, the mean DeMeester score (DMS) was 38.1 ± 34.6 in the COPD group and 13.3 ± 16.8 in the control group (p = 0.01). The acid reflux (DMS > 14.7) rate was higher in patients with COPD than in controls (73.9% vs 26.3%, p = 0.01). The symptom association probability positivity rate was 17.4% (n = 4) in the COPD group, which was similar to the controls (p = 0.11). The mean proximal extension rate of reflux (Z 17 cm) was 26.4 ± 12.9% in the COPD group. The proximal extent of reflux was positively correlated with the number of COPD exacerbations per year (p = 0.03, r = 0.448). In the motility results, only 2 (20%) patients in the control group had a minor motility disorder. Seventeen (70.8%) patients in the COPD group had a minor motility disorder, and 4 (16.7%) had major motility disorders (p |
| doi_str_mv | 10.1016/j.rmed.2016.04.005 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1808646165</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0954611116300622</els_id><sourcerecordid>1791334653</sourcerecordid><originalsourceid>FETCH-LOGICAL-c516t-416fb7ae6da1928481cf4360089d79087e54c1d79b1d3cc641308abc6134239f3</originalsourceid><addsrcrecordid>eNqFkk9v1DAQxS0EokvhC3BAkbhwSZixHceREAiV8keqxAG4cLEcZ9J6ycaLnVTtt8fptkLqAU5-kn_zpHlvGHuOUCGger2t4o76imddgawA6gdsg7XgpQAlH7INtLUsFSIesScpbQGglRIesyPecKxl227Yzw-BUnFu0xyzCPsLe052LCIN43JV-MlFsokKdxHD5F0RugwubvaXVOyXcRcmG6-L3qcbiq6so9jZ2YcpvXvKHg12TPTs9j1mPz6efj_5XJ59_fTl5P1Z6WpUcylRDV1jSfUWW66lRjdIoQB02zct6IZq6TDLDnvhnJIoQNvOKRSSi3YQx-zVwXcfw--F0mx2PjkaRztRWJJBDVpJhar-P9q0KITMZEZf3kO3YYlTXuRANbpWOlP8QLkYUsqpmX30u5yJQTBrSWZr1pLMWpIBaXJJeejFrfXSrX93I3etZODNAaAc26WnaJLzNDnqfSQ3mz74f_u_vTfuRp_bs-Mvuqb0dw-TuAHzbT2T9UpQCQDFufgDoNe3NA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1791378568</pqid></control><display><type>article</type><title>Does gastroesophageal reflux increase chronic obstructive pulmonary disease exacerbations?</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><source>EZB Electronic Journals Library</source><creator>Iliaz, Sinem ; Iliaz, Raim ; Onur, Seda Tural ; Arici, Serpil ; Akyuz, Umit ; Karaca, Cetin ; Demir, Kadir ; Besisik, Fatih ; Kaymakoglu, Sabahattin ; Akyuz, Filiz</creator><creatorcontrib>Iliaz, Sinem ; Iliaz, Raim ; Onur, Seda Tural ; Arici, Serpil ; Akyuz, Umit ; Karaca, Cetin ; Demir, Kadir ; Besisik, Fatih ; Kaymakoglu, Sabahattin ; Akyuz, Filiz</creatorcontrib><description>Abstract Background The relationship between chronic obstructive pulmonary disease (COPD) exacerbations and gastroesophageal reflux (GER) has been investigated less than asthma-GER. We aimed to evaluate the presence of GER in patients with COPD and its impact on exacerbations. Methods We included 24 patients with stable mild-moderate stage COPD and 19 volunteers as the control group. We conducted a gastroesophageal reflux disease (GERD) symptom questionnaire, gastroscopy, manometry, and an ambulatory 24-h pH-impedance study. Results According to the GERD questionnaire, only 5 (20.8%) patients with COPD had typical GER symptoms. According to the 24-h pH-impedance study, the mean DeMeester score (DMS) was 38.1 ± 34.6 in the COPD group and 13.3 ± 16.8 in the control group (p = 0.01). The acid reflux (DMS > 14.7) rate was higher in patients with COPD than in controls (73.9% vs 26.3%, p = 0.01). The symptom association probability positivity rate was 17.4% (n = 4) in the COPD group, which was similar to the controls (p = 0.11). The mean proximal extension rate of reflux (Z 17 cm) was 26.4 ± 12.9% in the COPD group. The proximal extent of reflux was positively correlated with the number of COPD exacerbations per year (p = 0.03, r = 0.448). In the motility results, only 2 (20%) patients in the control group had a minor motility disorder. Seventeen (70.8%) patients in the COPD group had a minor motility disorder, and 4 (16.7%) had major motility disorders (p < 0.001). Conclusion In our study, gastroesophageal reflux was frequent in patients with COPD, but only a quarter had typical reflux symptoms. The proximal extent of reflux may trigger frequent exacerbations of COPD.</description><identifier>ISSN: 0954-6111</identifier><identifier>EISSN: 1532-3064</identifier><identifier>DOI: 10.1016/j.rmed.2016.04.005</identifier><identifier>PMID: 27215499</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Adult ; Aged ; Body mass index ; Chronic obstructive pulmonary disease ; COPD ; Esophageal pH Monitoring - methods ; Exacerbation ; Female ; Gastroesophageal reflux ; Gastroesophageal Reflux - complications ; Gastroesophageal Reflux - epidemiology ; Gastroesophageal Reflux - physiopathology ; Gastroscopy - methods ; HRM ; Humans ; Impedance ; Male ; Manometry - methods ; Middle Aged ; Mortality ; Patients ; pH monitoring ; Prevalence ; Pulmonary Disease, Chronic Obstructive - complications ; Pulmonary Disease, Chronic Obstructive - epidemiology ; Pulmonary Disease, Chronic Obstructive - physiopathology ; Pulmonary/Respiratory ; Surveys and Questionnaires</subject><ispartof>Respiratory medicine, 2016-06, Vol.115, p.20-25</ispartof><rights>Elsevier Ltd</rights><rights>2016 Elsevier Ltd</rights><rights>Copyright © 2016 Elsevier Ltd. All rights reserved.</rights><rights>Copyright Elsevier Limited Jun 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c516t-416fb7ae6da1928481cf4360089d79087e54c1d79b1d3cc641308abc6134239f3</citedby><cites>FETCH-LOGICAL-c516t-416fb7ae6da1928481cf4360089d79087e54c1d79b1d3cc641308abc6134239f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.rmed.2016.04.005$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27215499$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Iliaz, Sinem</creatorcontrib><creatorcontrib>Iliaz, Raim</creatorcontrib><creatorcontrib>Onur, Seda Tural</creatorcontrib><creatorcontrib>Arici, Serpil</creatorcontrib><creatorcontrib>Akyuz, Umit</creatorcontrib><creatorcontrib>Karaca, Cetin</creatorcontrib><creatorcontrib>Demir, Kadir</creatorcontrib><creatorcontrib>Besisik, Fatih</creatorcontrib><creatorcontrib>Kaymakoglu, Sabahattin</creatorcontrib><creatorcontrib>Akyuz, Filiz</creatorcontrib><title>Does gastroesophageal reflux increase chronic obstructive pulmonary disease exacerbations?</title><title>Respiratory medicine</title><addtitle>Respir Med</addtitle><description>Abstract Background The relationship between chronic obstructive pulmonary disease (COPD) exacerbations and gastroesophageal reflux (GER) has been investigated less than asthma-GER. We aimed to evaluate the presence of GER in patients with COPD and its impact on exacerbations. Methods We included 24 patients with stable mild-moderate stage COPD and 19 volunteers as the control group. We conducted a gastroesophageal reflux disease (GERD) symptom questionnaire, gastroscopy, manometry, and an ambulatory 24-h pH-impedance study. Results According to the GERD questionnaire, only 5 (20.8%) patients with COPD had typical GER symptoms. According to the 24-h pH-impedance study, the mean DeMeester score (DMS) was 38.1 ± 34.6 in the COPD group and 13.3 ± 16.8 in the control group (p = 0.01). The acid reflux (DMS > 14.7) rate was higher in patients with COPD than in controls (73.9% vs 26.3%, p = 0.01). The symptom association probability positivity rate was 17.4% (n = 4) in the COPD group, which was similar to the controls (p = 0.11). The mean proximal extension rate of reflux (Z 17 cm) was 26.4 ± 12.9% in the COPD group. The proximal extent of reflux was positively correlated with the number of COPD exacerbations per year (p = 0.03, r = 0.448). In the motility results, only 2 (20%) patients in the control group had a minor motility disorder. Seventeen (70.8%) patients in the COPD group had a minor motility disorder, and 4 (16.7%) had major motility disorders (p < 0.001). Conclusion In our study, gastroesophageal reflux was frequent in patients with COPD, but only a quarter had typical reflux symptoms. The proximal extent of reflux may trigger frequent exacerbations of COPD.</description><subject>Adult</subject><subject>Aged</subject><subject>Body mass index</subject><subject>Chronic obstructive pulmonary disease</subject><subject>COPD</subject><subject>Esophageal pH Monitoring - methods</subject><subject>Exacerbation</subject><subject>Female</subject><subject>Gastroesophageal reflux</subject><subject>Gastroesophageal Reflux - complications</subject><subject>Gastroesophageal Reflux - epidemiology</subject><subject>Gastroesophageal Reflux - physiopathology</subject><subject>Gastroscopy - methods</subject><subject>HRM</subject><subject>Humans</subject><subject>Impedance</subject><subject>Male</subject><subject>Manometry - methods</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Patients</subject><subject>pH monitoring</subject><subject>Prevalence</subject><subject>Pulmonary Disease, Chronic Obstructive - complications</subject><subject>Pulmonary Disease, Chronic Obstructive - epidemiology</subject><subject>Pulmonary Disease, Chronic Obstructive - physiopathology</subject><subject>Pulmonary/Respiratory</subject><subject>Surveys and Questionnaires</subject><issn>0954-6111</issn><issn>1532-3064</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkk9v1DAQxS0EokvhC3BAkbhwSZixHceREAiV8keqxAG4cLEcZ9J6ycaLnVTtt8fptkLqAU5-kn_zpHlvGHuOUCGger2t4o76imddgawA6gdsg7XgpQAlH7INtLUsFSIesScpbQGglRIesyPecKxl227Yzw-BUnFu0xyzCPsLe052LCIN43JV-MlFsokKdxHD5F0RugwubvaXVOyXcRcmG6-L3qcbiq6so9jZ2YcpvXvKHg12TPTs9j1mPz6efj_5XJ59_fTl5P1Z6WpUcylRDV1jSfUWW66lRjdIoQB02zct6IZq6TDLDnvhnJIoQNvOKRSSi3YQx-zVwXcfw--F0mx2PjkaRztRWJJBDVpJhar-P9q0KITMZEZf3kO3YYlTXuRANbpWOlP8QLkYUsqpmX30u5yJQTBrSWZr1pLMWpIBaXJJeejFrfXSrX93I3etZODNAaAc26WnaJLzNDnqfSQ3mz74f_u_vTfuRp_bs-Mvuqb0dw-TuAHzbT2T9UpQCQDFufgDoNe3NA</recordid><startdate>20160601</startdate><enddate>20160601</enddate><creator>Iliaz, Sinem</creator><creator>Iliaz, Raim</creator><creator>Onur, Seda Tural</creator><creator>Arici, Serpil</creator><creator>Akyuz, Umit</creator><creator>Karaca, Cetin</creator><creator>Demir, Kadir</creator><creator>Besisik, Fatih</creator><creator>Kaymakoglu, Sabahattin</creator><creator>Akyuz, Filiz</creator><general>Elsevier Ltd</general><general>Elsevier Limited</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>ASE</scope><scope>FPQ</scope><scope>H94</scope><scope>K6X</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>7ST</scope><scope>C1K</scope><scope>SOI</scope></search><sort><creationdate>20160601</creationdate><title>Does gastroesophageal reflux increase chronic obstructive pulmonary disease exacerbations?</title><author>Iliaz, Sinem ; Iliaz, Raim ; Onur, Seda Tural ; Arici, Serpil ; Akyuz, Umit ; Karaca, Cetin ; Demir, Kadir ; Besisik, Fatih ; Kaymakoglu, Sabahattin ; Akyuz, Filiz</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c516t-416fb7ae6da1928481cf4360089d79087e54c1d79b1d3cc641308abc6134239f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Body mass index</topic><topic>Chronic obstructive pulmonary disease</topic><topic>COPD</topic><topic>Esophageal pH Monitoring - methods</topic><topic>Exacerbation</topic><topic>Female</topic><topic>Gastroesophageal reflux</topic><topic>Gastroesophageal Reflux - complications</topic><topic>Gastroesophageal Reflux - epidemiology</topic><topic>Gastroesophageal Reflux - physiopathology</topic><topic>Gastroscopy - methods</topic><topic>HRM</topic><topic>Humans</topic><topic>Impedance</topic><topic>Male</topic><topic>Manometry - methods</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Patients</topic><topic>pH monitoring</topic><topic>Prevalence</topic><topic>Pulmonary Disease, Chronic Obstructive - complications</topic><topic>Pulmonary Disease, Chronic Obstructive - epidemiology</topic><topic>Pulmonary Disease, Chronic Obstructive - physiopathology</topic><topic>Pulmonary/Respiratory</topic><topic>Surveys and Questionnaires</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Iliaz, Sinem</creatorcontrib><creatorcontrib>Iliaz, Raim</creatorcontrib><creatorcontrib>Onur, Seda Tural</creatorcontrib><creatorcontrib>Arici, Serpil</creatorcontrib><creatorcontrib>Akyuz, Umit</creatorcontrib><creatorcontrib>Karaca, Cetin</creatorcontrib><creatorcontrib>Demir, Kadir</creatorcontrib><creatorcontrib>Besisik, Fatih</creatorcontrib><creatorcontrib>Kaymakoglu, Sabahattin</creatorcontrib><creatorcontrib>Akyuz, Filiz</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>British Nursing Index</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>British Nursing Index</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>Environment Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Environment Abstracts</collection><jtitle>Respiratory medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Iliaz, Sinem</au><au>Iliaz, Raim</au><au>Onur, Seda Tural</au><au>Arici, Serpil</au><au>Akyuz, Umit</au><au>Karaca, Cetin</au><au>Demir, Kadir</au><au>Besisik, Fatih</au><au>Kaymakoglu, Sabahattin</au><au>Akyuz, Filiz</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Does gastroesophageal reflux increase chronic obstructive pulmonary disease exacerbations?</atitle><jtitle>Respiratory medicine</jtitle><addtitle>Respir Med</addtitle><date>2016-06-01</date><risdate>2016</risdate><volume>115</volume><spage>20</spage><epage>25</epage><pages>20-25</pages><issn>0954-6111</issn><eissn>1532-3064</eissn><abstract>Abstract Background The relationship between chronic obstructive pulmonary disease (COPD) exacerbations and gastroesophageal reflux (GER) has been investigated less than asthma-GER. We aimed to evaluate the presence of GER in patients with COPD and its impact on exacerbations. Methods We included 24 patients with stable mild-moderate stage COPD and 19 volunteers as the control group. We conducted a gastroesophageal reflux disease (GERD) symptom questionnaire, gastroscopy, manometry, and an ambulatory 24-h pH-impedance study. Results According to the GERD questionnaire, only 5 (20.8%) patients with COPD had typical GER symptoms. According to the 24-h pH-impedance study, the mean DeMeester score (DMS) was 38.1 ± 34.6 in the COPD group and 13.3 ± 16.8 in the control group (p = 0.01). The acid reflux (DMS > 14.7) rate was higher in patients with COPD than in controls (73.9% vs 26.3%, p = 0.01). The symptom association probability positivity rate was 17.4% (n = 4) in the COPD group, which was similar to the controls (p = 0.11). The mean proximal extension rate of reflux (Z 17 cm) was 26.4 ± 12.9% in the COPD group. The proximal extent of reflux was positively correlated with the number of COPD exacerbations per year (p = 0.03, r = 0.448). In the motility results, only 2 (20%) patients in the control group had a minor motility disorder. Seventeen (70.8%) patients in the COPD group had a minor motility disorder, and 4 (16.7%) had major motility disorders (p < 0.001). Conclusion In our study, gastroesophageal reflux was frequent in patients with COPD, but only a quarter had typical reflux symptoms. The proximal extent of reflux may trigger frequent exacerbations of COPD.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>27215499</pmid><doi>10.1016/j.rmed.2016.04.005</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0954-6111 |
| ispartof | Respiratory medicine, 2016-06, Vol.115, p.20-25 |
| issn | 0954-6111 1532-3064 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1808646165 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete; EZB Electronic Journals Library |
| subjects | Adult Aged Body mass index Chronic obstructive pulmonary disease COPD Esophageal pH Monitoring - methods Exacerbation Female Gastroesophageal reflux Gastroesophageal Reflux - complications Gastroesophageal Reflux - epidemiology Gastroesophageal Reflux - physiopathology Gastroscopy - methods HRM Humans Impedance Male Manometry - methods Middle Aged Mortality Patients pH monitoring Prevalence Pulmonary Disease, Chronic Obstructive - complications Pulmonary Disease, Chronic Obstructive - epidemiology Pulmonary Disease, Chronic Obstructive - physiopathology Pulmonary/Respiratory Surveys and Questionnaires |
| title | Does gastroesophageal reflux increase chronic obstructive pulmonary disease exacerbations? |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-01T06%3A22%3A53IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Does%20gastroesophageal%20reflux%20increase%20chronic%20obstructive%20pulmonary%20disease%20exacerbations?&rft.jtitle=Respiratory%20medicine&rft.au=Iliaz,%20Sinem&rft.date=2016-06-01&rft.volume=115&rft.spage=20&rft.epage=25&rft.pages=20-25&rft.issn=0954-6111&rft.eissn=1532-3064&rft_id=info:doi/10.1016/j.rmed.2016.04.005&rft_dat=%3Cproquest_cross%3E1791334653%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1791378568&rft_id=info:pmid/27215499&rft_els_id=1_s2_0_S0954611116300622&rfr_iscdi=true |