Transcriptional and Epigenetic Regulation of Innate Immune Cell Development by the Transcription Factor, Interferon Regulatory Factor-8

The transcription factor, interferon regulatory factor-8 (IRF8), is required for the development of monocytes, macrophages, dendritic cells (DCs), basophils, and eosinophils, while it inhibits the generation of neutrophils. Recently, the molecular mechanisms by which IRF8 regulates their development...

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Veröffentlicht in:	Journal of interferon & cytokine research 2016-07, Vol.36 (7), p.433-441
Hauptverfasser:	Kurotaki, Daisuke, Tamura, Tomohiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Differentiation - genetics Cell Differentiation - immunology Dendritic Cells - cytology Dendritic Cells - immunology Dendritic Cells - metabolism Epigenesis, Genetic Gene Expression Regulation Humans Immune System - cytology Immune System - physiology Immunity, Innate - genetics Interferon Regulatory Factors - genetics Interferon Regulatory Factors - metabolism Myeloid Cells - cytology Myeloid Cells - immunology Myeloid Cells - metabolism Myelopoiesis - genetics Myelopoiesis - immunology Transcription, Genetic
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