Nuclear localization of N-terminal mutant huntingtin is cell cycle dependent

Unlike normal huntingtin (htt) which is located predominantly in the cytoplasm, mutant htt is also found in the nucleus of affected neurons. Nuclear localization of toxic polyglutamine‐containing proteins has been postulated to be necessary for the pathogenesis of triplet repeat disorders. However,...

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Veröffentlicht in:	The European journal of neuroscience 2002-07, Vol.16 (2), p.355-359
Hauptverfasser:	Martín-Aparicio, Ester, Avila, Jesús, Lucas, José J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Active Transport, Cell Nucleus - genetics Animals Animals, Newborn Cell Compartmentation - genetics Cell Cycle - genetics cell cycle arrest Cell Nucleus - genetics Cell Nucleus - metabolism Cell Nucleus - pathology Cells, Cultured Coculture Techniques Cytoplasm - genetics Cytoplasm - metabolism glia Huntington Disease - genetics Huntington Disease - metabolism Huntington Disease - physiopathology Huntington's disease Mice Mice, Neurologic Mutants Mutation - genetics Neostriatum - metabolism Neostriatum - pathology Neostriatum - physiopathology Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Neuroglia - metabolism Neuroglia - pathology neuron Neurons - metabolism Neurons - pathology Nuclear Proteins - genetics Nuclear Proteins - metabolism primary culture Protein Structure, Tertiary - genetics
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