Decreased expression of miR-146a and miR-155 contributes to an abnormal Treg phenotype in patients with rheumatoid arthritis

Objectives MicroRNAs (miRNAs) have been implicated in the pathogenesis of autoimmune diseases, not least for their critical role in the regulation of regulatory T cell (Treg) function. Deregulated expression of miR-146a and miR-155 has been associated with rheumatoid arthritis (RA). We therefore inv...

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Veröffentlicht in:	Annals of the rheumatic diseases 2015-06, Vol.74 (6), p.1265-1274
Hauptverfasser:	Zhou, Qihui, Haupt, Sonja, Kreuzer, Johannes T, Hammitzsch, Ariane, Proft, Fabian, Neumann, Carla, Leipe, Jan, Witt, Matthias, Schulze-Koops, Hendrik, Skapenko, Alla
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Arthritis, Rheumatoid - genetics Arthritis, Rheumatoid - immunology Autoimmune diseases Case-Control Studies Disease Female Genotype & phenotype Government agencies Humans Inflammation Lymphocytes Male MicroRNAs - genetics MicroRNAs - metabolism Middle Aged Pathogenesis Proteins Regulation Rheumatoid arthritis RNA, Messenger - metabolism STAT1 Transcription Factor - genetics STAT1 Transcription Factor - metabolism T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - metabolism TNF inhibitors Tumor necrosis factor-TNF
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