Histone Deacetylase SIRT1 Negatively Regulates the Differentiation of Interleukin-9-Producing CD4+ T Cells

Distinct metabolic programs support the differentiation of CD4+ T cells into separate functional subsets. In this study, we investigated metabolic mechanisms underlying the differentiation of IL-9-producing CD4+ T cells (Th9) in allergic airway inflammation and cancerous tumors. We found that histon...

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Veröffentlicht in:	Immunity (Cambridge, Mass.) Mass.), 2016-06, Vol.44 (6), p.1337-1349
Hauptverfasser:	Wang, Yu, Bi, Yujing, Chen, Xi, Li, Chunxiao, Li, Yan, Zhang, Zhengguo, Wang, Jian, Lu, Yun, Yu, Qing, Su, Huilin, Yang, Hui, Liu, Guangwei
Format:	Artikel
Sprache:	eng
Schlagworte:	allergic airway inflammation Animals Cell Differentiation Cells, Cultured Dendritic cells Gene expression Glycolysis Humans Hypersensitivity - immunology Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Interleukin-9 - metabolism Kinases Lymphocytes MAP Kinase Kinase Kinases - metabolism Melanoma - immunology Melanoma, Experimental Metabolism Mice Mice, Inbred C57BL Mice, Knockout Neoplasms, Experimental RNA, Small Interfering - genetics Signal Transduction SIRT1 Sirtuin 1 - genetics Sirtuin 1 - metabolism T cell differentiation T-Lymphocytes, Helper-Inducer - immunology Th9 cells TOR Serine-Threonine Kinases - metabolism Transcriptional Activation tumor
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