Association of serum vascular endothelial growth factor levels and cerebral microbleeds in patients with Alzheimer's disease
Background and purpose The association between the presence of cerebral microbleeds (CMBs) and serum vascular endothelial growth factor (VEGF) levels in patients with Alzheimer's disease (AD) was investigated. Methods Consecutive AD patients who underwent magnetic resonance examination with sus...
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| Veröffentlicht in: | European journal of neurology 2016-08, Vol.23 (8), p.1337-1342 |
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| container_title | European journal of neurology |
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| creator | Zhang, J. B. Li, M. F. Zhang, H. X. Li, Z. G. Sun, H. R. Zhang, J. S. Wang, P. F. |
| description | Background and purpose
The association between the presence of cerebral microbleeds (CMBs) and serum vascular endothelial growth factor (VEGF) levels in patients with Alzheimer's disease (AD) was investigated.
Methods
Consecutive AD patients who underwent magnetic resonance examination with susceptibility‐weighted imaging (SWI) were prospectively examined. The presence of CMBs on SWI was independently interpreted. The number and location of microbleeds were assessed. Demographics including age, sex and risk factors were obtained. Serum VEGF levels were measured with an enzyme‐linked immunosorbent assay.
Results
Of the 146 AD patients included, 47 (32.2%) patients had CMBs on SWI. The CMBs were most commonly located in strictly lobar locations (29/47, 61.7%). The mean VEGF levels were higher in the patients with CMBs than in those without (336.72 ± 15.18 vs. 192.37 ± 11.34 pg/ml). Multivariate logistic regression analyses showed that, for each 10 pg/ml increase of VEGF levels, there was a significant increase in the presence of CMBs after adjusting for age and sex, and after additional adjustment for cardiovascular risk factors, silent lacunar infarction and white matter hyperintensity in patients with AD (odds ratio 2.37; 95% confidence interval 1.53−4.02, P = 0.004).
Conclusion
Serum VEGF levels are associated with the presence of CMBs in patients with AD. |
| doi_str_mv | 10.1111/ene.13030 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1808640159</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>4121098881</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4240-390877238325c30c5bf46604ad097f0ac8c1cefa10c69ad93dd6c66045cace3d3</originalsourceid><addsrcrecordid>eNqNkT1vFDEQhi0EIiFQ8AeQJQpIscnYXu9HeUSXAAqhAUJn-exZzsG7vti7uQTx4_HlkhRISLgZF8_7SDMvIS8ZHLD8DnHAAyZAwCOyy8qqKZgQ7HH-C8kKyYDtkGcpXQAArzk8JTu8ZrwBLnbJ71lKwTg9ujDQ0NGEcerplU5m8jpSHGwYl-id9vRHDOtxSTttxhCpxyv0ierBUoMRFzETvTMxLDyiTdQNdJWtOIyJrl3OzfyvJboe45tErUuoEz4nTzrtE764m3vk6_H8y9H74vTzyYej2WlhSl5CIVpo6pqLRnBpBBi56MqqglJbaOsOtGkMM9hpBqZqtW2FtZXZANJog8KKPfJ2613FcDlhGlXvkkHv9YBhSoo10FQlMNn-Dypr2fK2yujrv9CLMMUhL3JLcVFKvhHub6l8mpQidmoVXa_jjWKgNu2p3J66bS-zr-6M06JH-0De15WBwy2wdh5v_m1S87P5vbLYJlwa8fohoeNPVdWilur87EQdn3_7_u5jI9Un8Qc-gbNb</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1805234529</pqid></control><display><type>article</type><title>Association of serum vascular endothelial growth factor levels and cerebral microbleeds in patients with Alzheimer's disease</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Zhang, J. B. ; Li, M. F. ; Zhang, H. X. ; Li, Z. G. ; Sun, H. R. ; Zhang, J. S. ; Wang, P. F.</creator><creatorcontrib>Zhang, J. B. ; Li, M. F. ; Zhang, H. X. ; Li, Z. G. ; Sun, H. R. ; Zhang, J. S. ; Wang, P. F.</creatorcontrib><description>Background and purpose
The association between the presence of cerebral microbleeds (CMBs) and serum vascular endothelial growth factor (VEGF) levels in patients with Alzheimer's disease (AD) was investigated.
Methods
Consecutive AD patients who underwent magnetic resonance examination with susceptibility‐weighted imaging (SWI) were prospectively examined. The presence of CMBs on SWI was independently interpreted. The number and location of microbleeds were assessed. Demographics including age, sex and risk factors were obtained. Serum VEGF levels were measured with an enzyme‐linked immunosorbent assay.
Results
Of the 146 AD patients included, 47 (32.2%) patients had CMBs on SWI. The CMBs were most commonly located in strictly lobar locations (29/47, 61.7%). The mean VEGF levels were higher in the patients with CMBs than in those without (336.72 ± 15.18 vs. 192.37 ± 11.34 pg/ml). Multivariate logistic regression analyses showed that, for each 10 pg/ml increase of VEGF levels, there was a significant increase in the presence of CMBs after adjusting for age and sex, and after additional adjustment for cardiovascular risk factors, silent lacunar infarction and white matter hyperintensity in patients with AD (odds ratio 2.37; 95% confidence interval 1.53−4.02, P = 0.004).
Conclusion
Serum VEGF levels are associated with the presence of CMBs in patients with AD.</description><identifier>ISSN: 1351-5101</identifier><identifier>EISSN: 1468-1331</identifier><identifier>DOI: 10.1111/ene.13030</identifier><identifier>PMID: 27128023</identifier><identifier>CODEN: EJNEFL</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Aged ; Aged, 80 and over ; Alzheimer Disease - blood ; Alzheimer Disease - complications ; Alzheimer Disease - diagnostic imaging ; Alzheimer's disease ; Cerebral Hemorrhage - blood ; Cerebral Hemorrhage - complications ; Cerebral Hemorrhage - diagnostic imaging ; cerebral microbleeds ; Female ; Humans ; Magnetic Resonance Imaging - methods ; Male ; Middle Aged ; Risk Factors ; serum ; Stroke, Lacunar - blood ; Stroke, Lacunar - complications ; Stroke, Lacunar - diagnostic imaging ; susceptibility-weighted imaging ; vascular endothelial growth factor ; Vascular Endothelial Growth Factor A - blood</subject><ispartof>European journal of neurology, 2016-08, Vol.23 (8), p.1337-1342</ispartof><rights>2016 EAN</rights><rights>2016 EAN.</rights><rights>European Journal of Neurology © 2016 European Academy of Neurology</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4240-390877238325c30c5bf46604ad097f0ac8c1cefa10c69ad93dd6c66045cace3d3</citedby><cites>FETCH-LOGICAL-c4240-390877238325c30c5bf46604ad097f0ac8c1cefa10c69ad93dd6c66045cace3d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fene.13030$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fene.13030$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27128023$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, J. B.</creatorcontrib><creatorcontrib>Li, M. F.</creatorcontrib><creatorcontrib>Zhang, H. X.</creatorcontrib><creatorcontrib>Li, Z. G.</creatorcontrib><creatorcontrib>Sun, H. R.</creatorcontrib><creatorcontrib>Zhang, J. S.</creatorcontrib><creatorcontrib>Wang, P. F.</creatorcontrib><title>Association of serum vascular endothelial growth factor levels and cerebral microbleeds in patients with Alzheimer's disease</title><title>European journal of neurology</title><addtitle>Eur J Neurol</addtitle><description>Background and purpose
The association between the presence of cerebral microbleeds (CMBs) and serum vascular endothelial growth factor (VEGF) levels in patients with Alzheimer's disease (AD) was investigated.
Methods
Consecutive AD patients who underwent magnetic resonance examination with susceptibility‐weighted imaging (SWI) were prospectively examined. The presence of CMBs on SWI was independently interpreted. The number and location of microbleeds were assessed. Demographics including age, sex and risk factors were obtained. Serum VEGF levels were measured with an enzyme‐linked immunosorbent assay.
Results
Of the 146 AD patients included, 47 (32.2%) patients had CMBs on SWI. The CMBs were most commonly located in strictly lobar locations (29/47, 61.7%). The mean VEGF levels were higher in the patients with CMBs than in those without (336.72 ± 15.18 vs. 192.37 ± 11.34 pg/ml). Multivariate logistic regression analyses showed that, for each 10 pg/ml increase of VEGF levels, there was a significant increase in the presence of CMBs after adjusting for age and sex, and after additional adjustment for cardiovascular risk factors, silent lacunar infarction and white matter hyperintensity in patients with AD (odds ratio 2.37; 95% confidence interval 1.53−4.02, P = 0.004).
Conclusion
Serum VEGF levels are associated with the presence of CMBs in patients with AD.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alzheimer Disease - blood</subject><subject>Alzheimer Disease - complications</subject><subject>Alzheimer Disease - diagnostic imaging</subject><subject>Alzheimer's disease</subject><subject>Cerebral Hemorrhage - blood</subject><subject>Cerebral Hemorrhage - complications</subject><subject>Cerebral Hemorrhage - diagnostic imaging</subject><subject>cerebral microbleeds</subject><subject>Female</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Risk Factors</subject><subject>serum</subject><subject>Stroke, Lacunar - blood</subject><subject>Stroke, Lacunar - complications</subject><subject>Stroke, Lacunar - diagnostic imaging</subject><subject>susceptibility-weighted imaging</subject><subject>vascular endothelial growth factor</subject><subject>Vascular Endothelial Growth Factor A - blood</subject><issn>1351-5101</issn><issn>1468-1331</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkT1vFDEQhi0EIiFQ8AeQJQpIscnYXu9HeUSXAAqhAUJn-exZzsG7vti7uQTx4_HlkhRISLgZF8_7SDMvIS8ZHLD8DnHAAyZAwCOyy8qqKZgQ7HH-C8kKyYDtkGcpXQAArzk8JTu8ZrwBLnbJ71lKwTg9ujDQ0NGEcerplU5m8jpSHGwYl-id9vRHDOtxSTttxhCpxyv0ierBUoMRFzETvTMxLDyiTdQNdJWtOIyJrl3OzfyvJboe45tErUuoEz4nTzrtE764m3vk6_H8y9H74vTzyYej2WlhSl5CIVpo6pqLRnBpBBi56MqqglJbaOsOtGkMM9hpBqZqtW2FtZXZANJog8KKPfJ2613FcDlhGlXvkkHv9YBhSoo10FQlMNn-Dypr2fK2yujrv9CLMMUhL3JLcVFKvhHub6l8mpQidmoVXa_jjWKgNu2p3J66bS-zr-6M06JH-0De15WBwy2wdh5v_m1S87P5vbLYJlwa8fohoeNPVdWilur87EQdn3_7_u5jI9Un8Qc-gbNb</recordid><startdate>201608</startdate><enddate>201608</enddate><creator>Zhang, J. B.</creator><creator>Li, M. F.</creator><creator>Zhang, H. X.</creator><creator>Li, Z. G.</creator><creator>Sun, H. R.</creator><creator>Zhang, J. S.</creator><creator>Wang, P. F.</creator><general>Blackwell Publishing Ltd</general><general>John Wiley & Sons, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201608</creationdate><title>Association of serum vascular endothelial growth factor levels and cerebral microbleeds in patients with Alzheimer's disease</title><author>Zhang, J. B. ; Li, M. F. ; Zhang, H. X. ; Li, Z. G. ; Sun, H. R. ; Zhang, J. S. ; Wang, P. F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4240-390877238325c30c5bf46604ad097f0ac8c1cefa10c69ad93dd6c66045cace3d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Alzheimer Disease - blood</topic><topic>Alzheimer Disease - complications</topic><topic>Alzheimer Disease - diagnostic imaging</topic><topic>Alzheimer's disease</topic><topic>Cerebral Hemorrhage - blood</topic><topic>Cerebral Hemorrhage - complications</topic><topic>Cerebral Hemorrhage - diagnostic imaging</topic><topic>cerebral microbleeds</topic><topic>Female</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Risk Factors</topic><topic>serum</topic><topic>Stroke, Lacunar - blood</topic><topic>Stroke, Lacunar - complications</topic><topic>Stroke, Lacunar - diagnostic imaging</topic><topic>susceptibility-weighted imaging</topic><topic>vascular endothelial growth factor</topic><topic>Vascular Endothelial Growth Factor A - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, J. B.</creatorcontrib><creatorcontrib>Li, M. F.</creatorcontrib><creatorcontrib>Zhang, H. X.</creatorcontrib><creatorcontrib>Li, Z. G.</creatorcontrib><creatorcontrib>Sun, H. R.</creatorcontrib><creatorcontrib>Zhang, J. S.</creatorcontrib><creatorcontrib>Wang, P. F.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, J. B.</au><au>Li, M. F.</au><au>Zhang, H. X.</au><au>Li, Z. G.</au><au>Sun, H. R.</au><au>Zhang, J. S.</au><au>Wang, P. F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of serum vascular endothelial growth factor levels and cerebral microbleeds in patients with Alzheimer's disease</atitle><jtitle>European journal of neurology</jtitle><addtitle>Eur J Neurol</addtitle><date>2016-08</date><risdate>2016</risdate><volume>23</volume><issue>8</issue><spage>1337</spage><epage>1342</epage><pages>1337-1342</pages><issn>1351-5101</issn><eissn>1468-1331</eissn><coden>EJNEFL</coden><abstract>Background and purpose
The association between the presence of cerebral microbleeds (CMBs) and serum vascular endothelial growth factor (VEGF) levels in patients with Alzheimer's disease (AD) was investigated.
Methods
Consecutive AD patients who underwent magnetic resonance examination with susceptibility‐weighted imaging (SWI) were prospectively examined. The presence of CMBs on SWI was independently interpreted. The number and location of microbleeds were assessed. Demographics including age, sex and risk factors were obtained. Serum VEGF levels were measured with an enzyme‐linked immunosorbent assay.
Results
Of the 146 AD patients included, 47 (32.2%) patients had CMBs on SWI. The CMBs were most commonly located in strictly lobar locations (29/47, 61.7%). The mean VEGF levels were higher in the patients with CMBs than in those without (336.72 ± 15.18 vs. 192.37 ± 11.34 pg/ml). Multivariate logistic regression analyses showed that, for each 10 pg/ml increase of VEGF levels, there was a significant increase in the presence of CMBs after adjusting for age and sex, and after additional adjustment for cardiovascular risk factors, silent lacunar infarction and white matter hyperintensity in patients with AD (odds ratio 2.37; 95% confidence interval 1.53−4.02, P = 0.004).
Conclusion
Serum VEGF levels are associated with the presence of CMBs in patients with AD.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>27128023</pmid><doi>10.1111/ene.13030</doi><tpages>6</tpages></addata></record> |
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| language | eng |
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| source | MEDLINE; Access via Wiley Online Library |
| subjects | Aged Aged, 80 and over Alzheimer Disease - blood Alzheimer Disease - complications Alzheimer Disease - diagnostic imaging Alzheimer's disease Cerebral Hemorrhage - blood Cerebral Hemorrhage - complications Cerebral Hemorrhage - diagnostic imaging cerebral microbleeds Female Humans Magnetic Resonance Imaging - methods Male Middle Aged Risk Factors serum Stroke, Lacunar - blood Stroke, Lacunar - complications Stroke, Lacunar - diagnostic imaging susceptibility-weighted imaging vascular endothelial growth factor Vascular Endothelial Growth Factor A - blood |
| title | Association of serum vascular endothelial growth factor levels and cerebral microbleeds in patients with Alzheimer's disease |
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