Chronic lymphocytic leukemia: a paradigm of innate immune cross-tolerance

Infections are a significant cause of morbidity and mortality in patients with chronic lymphocytic leukemia (CLL). The pathogenesis of infections is multifactorial and includes hypogammaglobulinemia, conventional therapy with alkylating drugs, and recently, purine analogs and mAb-associated T cells....

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Veröffentlicht in:	The Journal of immunology (1950) 2015-01, Vol.194 (2), p.719-727
Hauptverfasser:	Jurado-Camino, Teresa, Córdoba, Raúl, Esteban-Burgos, Laura, Hernández-Jiménez, Enrique, Toledano, Victor, Hernandez-Rivas, Jose-Angel, Ruiz-Sainz, Elena, Cobo, Teresa, Siliceo, María, Perez de Diego, Rebeca, Belda, Cristobal, Cubillos-Zapata, Carolina, López-Collazo, Eduardo
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Cytokines - immunology Down-Regulation - immunology Endotoxins - immunology Female Gene Expression Regulation, Leukemic - immunology Humans Immune Tolerance Immunity, Innate Interleukin-1 Receptor-Associated Kinases - immunology Leukemia, Lymphocytic, Chronic, B-Cell - immunology Leukemia, Lymphocytic, Chronic, B-Cell - pathology Male MicroRNAs - immunology Middle Aged Monocytes - immunology Monocytes - pathology T-Lymphocytes - immunology T-Lymphocytes - pathology TNF Receptor-Associated Factor 6 - immunology
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