Motion and morphometry in clinical and nonclinical populations
The relationship between participant motion, demographic variables and MRI-derived morphometric estimates was investigated in autism spectrum disorder (ASD), attention deficit hyperactivity disorder (ADHD), schizophrenia and healthy controls. Participant motion was estimated using resting state fMRI...
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| Veröffentlicht in: | NeuroImage (Orlando, Fla.) Fla.), 2016-07, Vol.135, p.177-185 |
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| creator | Pardoe, Heath R. Kucharsky Hiess, Rebecca Kuzniecky, Ruben |
| description | The relationship between participant motion, demographic variables and MRI-derived morphometric estimates was investigated in autism spectrum disorder (ASD), attention deficit hyperactivity disorder (ADHD), schizophrenia and healthy controls. Participant motion was estimated using resting state fMRI and used as a proxy measure for motion during T1w MRI acquired in the same session. Analyses were carried out in scans qualitatively assessed as free from motion-related artifact.
Whole brain T1-weighted MRI and resting state fMRI acquisitions from the ABIDE, ADHD-200 and COBRE databases were included in our analyses. Motion was estimated using coregistration of sequential resting state volumes. We investigated if motion is related to diagnosis, age and gender, and scanning site. We further determined if there is a relationship between participant motion and cortical thickness, contrast, and volumetric estimates.
2141 participants were included in our analyses. Participant motion was higher in all clinical groups compared with healthy controls. Younger (age40years) people move more than individuals aged 20–40years. Increased motion is associated with reduced average cortical thickness (−0.014mm thickness per mm motion, p=0.0014) and cortical contrast (0.77% contrast reduction per mm motion, p=2.16×10−9) in scans that have been qualitatively assessed as free from motion artifact. Volumetric estimates were also associated with motion, however the relationships were generally weaker than cortical thickness and contrast and were dependent on the segmentation method used.
Participant motion is increased in clinical groups and is systematically associated with morphometric estimates. These findings indicate that accounting for participant motion may be important for improving the statistical validity of morphometric studies.
•We investigated subject motion and morphometry in clinical and nonclinical groups.•Motion was increased in clinical groups, across sites and in younger subjects.•Increased motion is generally associated with reduced morphometric estimates.•Systematic motion is a source of error in brain morphometry analyses. |
| doi_str_mv | 10.1016/j.neuroimage.2016.05.005 |
| format | Article |
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Whole brain T1-weighted MRI and resting state fMRI acquisitions from the ABIDE, ADHD-200 and COBRE databases were included in our analyses. Motion was estimated using coregistration of sequential resting state volumes. We investigated if motion is related to diagnosis, age and gender, and scanning site. We further determined if there is a relationship between participant motion and cortical thickness, contrast, and volumetric estimates.
2141 participants were included in our analyses. Participant motion was higher in all clinical groups compared with healthy controls. Younger (age<20years) and older (age>40years) people move more than individuals aged 20–40years. Increased motion is associated with reduced average cortical thickness (−0.014mm thickness per mm motion, p=0.0014) and cortical contrast (0.77% contrast reduction per mm motion, p=2.16×10−9) in scans that have been qualitatively assessed as free from motion artifact. Volumetric estimates were also associated with motion, however the relationships were generally weaker than cortical thickness and contrast and were dependent on the segmentation method used.
Participant motion is increased in clinical groups and is systematically associated with morphometric estimates. These findings indicate that accounting for participant motion may be important for improving the statistical validity of morphometric studies.
•We investigated subject motion and morphometry in clinical and nonclinical groups.•Motion was increased in clinical groups, across sites and in younger subjects.•Increased motion is generally associated with reduced morphometric estimates.•Systematic motion is a source of error in brain morphometry analyses.</description><identifier>ISSN: 1053-8119</identifier><identifier>EISSN: 1095-9572</identifier><identifier>DOI: 10.1016/j.neuroimage.2016.05.005</identifier><identifier>PMID: 27153982</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Aging - pathology ; Attention deficit hyperactivity disorder ; Autism ; Brain - pathology ; Brain Diseases - pathology ; Child ; Cortical thickness ; Estimates ; Female ; Humans ; Image Interpretation, Computer-Assisted - methods ; Imaging, Three-Dimensional - methods ; Magnetic Resonance Imaging - methods ; Male ; Middle Aged ; Motion ; Neuroanatomy ; Quality assurance ; Quality control ; Quantitative imaging ; Reproducibility of Results ; Schizophrenia ; Sensitivity and Specificity ; Sex Characteristics ; Sex Factors ; Software packages ; Studies ; Volumetry ; Websites ; Young Adult</subject><ispartof>NeuroImage (Orlando, Fla.), 2016-07, Vol.135, p.177-185</ispartof><rights>2016 Elsevier Inc.</rights><rights>Copyright © 2016 Elsevier Inc. All rights reserved.</rights><rights>Copyright Elsevier Limited Jul 15, 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c501t-8ed27c656c7fb576f1f1df264824e7bba5b05242969432e8c92d42138735f64a3</citedby><cites>FETCH-LOGICAL-c501t-8ed27c656c7fb576f1f1df264824e7bba5b05242969432e8c92d42138735f64a3</cites><orcidid>0000-0002-0123-2167</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1053811916301197$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27153982$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pardoe, Heath R.</creatorcontrib><creatorcontrib>Kucharsky Hiess, Rebecca</creatorcontrib><creatorcontrib>Kuzniecky, Ruben</creatorcontrib><title>Motion and morphometry in clinical and nonclinical populations</title><title>NeuroImage (Orlando, Fla.)</title><addtitle>Neuroimage</addtitle><description>The relationship between participant motion, demographic variables and MRI-derived morphometric estimates was investigated in autism spectrum disorder (ASD), attention deficit hyperactivity disorder (ADHD), schizophrenia and healthy controls. Participant motion was estimated using resting state fMRI and used as a proxy measure for motion during T1w MRI acquired in the same session. Analyses were carried out in scans qualitatively assessed as free from motion-related artifact.
Whole brain T1-weighted MRI and resting state fMRI acquisitions from the ABIDE, ADHD-200 and COBRE databases were included in our analyses. Motion was estimated using coregistration of sequential resting state volumes. We investigated if motion is related to diagnosis, age and gender, and scanning site. We further determined if there is a relationship between participant motion and cortical thickness, contrast, and volumetric estimates.
2141 participants were included in our analyses. Participant motion was higher in all clinical groups compared with healthy controls. Younger (age<20years) and older (age>40years) people move more than individuals aged 20–40years. Increased motion is associated with reduced average cortical thickness (−0.014mm thickness per mm motion, p=0.0014) and cortical contrast (0.77% contrast reduction per mm motion, p=2.16×10−9) in scans that have been qualitatively assessed as free from motion artifact. Volumetric estimates were also associated with motion, however the relationships were generally weaker than cortical thickness and contrast and were dependent on the segmentation method used.
Participant motion is increased in clinical groups and is systematically associated with morphometric estimates. These findings indicate that accounting for participant motion may be important for improving the statistical validity of morphometric studies.
•We investigated subject motion and morphometry in clinical and nonclinical groups.•Motion was increased in clinical groups, across sites and in younger subjects.•Increased motion is generally associated with reduced morphometric estimates.•Systematic motion is a source of error in brain morphometry analyses.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aging - pathology</subject><subject>Attention deficit hyperactivity disorder</subject><subject>Autism</subject><subject>Brain - pathology</subject><subject>Brain Diseases - pathology</subject><subject>Child</subject><subject>Cortical thickness</subject><subject>Estimates</subject><subject>Female</subject><subject>Humans</subject><subject>Image Interpretation, Computer-Assisted - methods</subject><subject>Imaging, Three-Dimensional - methods</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Motion</subject><subject>Neuroanatomy</subject><subject>Quality assurance</subject><subject>Quality control</subject><subject>Quantitative imaging</subject><subject>Reproducibility of Results</subject><subject>Schizophrenia</subject><subject>Sensitivity and Specificity</subject><subject>Sex Characteristics</subject><subject>Sex Factors</subject><subject>Software packages</subject><subject>Studies</subject><subject>Volumetry</subject><subject>Websites</subject><subject>Young Adult</subject><issn>1053-8119</issn><issn>1095-9572</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkUtPxSAQhYnR-Lj6F0wTN25agRYKGxM1vhKNG12Tlk6VmxYqtCb330u9V03cuAKG78xkzkEoITgjmPCzZWZh8s701StkNFYyzDKM2RbaJ1iyVLKSbs93lqeCELmHDkJYYowlKcQu2qMlYbkUdB-dP7rROJtUtkl654c318PoV4mxie6MNbrqvv6ssz_vwQ1TV82ycIh22qoLcLQ5F-jl5vr56i59eLq9v7p4SDXDZEwFNLTUnHFdtjUreUta0rSUF4IWUNZ1xWrMaEEll0VOQWhJm4KSXJQ5a3lR5Qt0uu47ePc-QRhVb4KGrqssuCkoIrDgueRR8y9aSiGjQTKP6MkfdOkmb-Mic0PMJSaCRUqsKe1dCB5aNfjovF8pgtUch1qq3zjUHIfCTMU4ovR4M2Cqe2h-hN_-R-ByDUA078OAV0EbsBoa40GPqnHm_ymf6Aae-A</recordid><startdate>20160715</startdate><enddate>20160715</enddate><creator>Pardoe, Heath R.</creator><creator>Kucharsky Hiess, Rebecca</creator><creator>Kuzniecky, Ruben</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope><scope>7QO</scope><orcidid>https://orcid.org/0000-0002-0123-2167</orcidid></search><sort><creationdate>20160715</creationdate><title>Motion and morphometry in clinical and nonclinical populations</title><author>Pardoe, Heath R. ; 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Participant motion was estimated using resting state fMRI and used as a proxy measure for motion during T1w MRI acquired in the same session. Analyses were carried out in scans qualitatively assessed as free from motion-related artifact.
Whole brain T1-weighted MRI and resting state fMRI acquisitions from the ABIDE, ADHD-200 and COBRE databases were included in our analyses. Motion was estimated using coregistration of sequential resting state volumes. We investigated if motion is related to diagnosis, age and gender, and scanning site. We further determined if there is a relationship between participant motion and cortical thickness, contrast, and volumetric estimates.
2141 participants were included in our analyses. Participant motion was higher in all clinical groups compared with healthy controls. Younger (age<20years) and older (age>40years) people move more than individuals aged 20–40years. Increased motion is associated with reduced average cortical thickness (−0.014mm thickness per mm motion, p=0.0014) and cortical contrast (0.77% contrast reduction per mm motion, p=2.16×10−9) in scans that have been qualitatively assessed as free from motion artifact. Volumetric estimates were also associated with motion, however the relationships were generally weaker than cortical thickness and contrast and were dependent on the segmentation method used.
Participant motion is increased in clinical groups and is systematically associated with morphometric estimates. These findings indicate that accounting for participant motion may be important for improving the statistical validity of morphometric studies.
•We investigated subject motion and morphometry in clinical and nonclinical groups.•Motion was increased in clinical groups, across sites and in younger subjects.•Increased motion is generally associated with reduced morphometric estimates.•Systematic motion is a source of error in brain morphometry analyses.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>27153982</pmid><doi>10.1016/j.neuroimage.2016.05.005</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-0123-2167</orcidid></addata></record> |
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| subjects | Adolescent Adult Aging - pathology Attention deficit hyperactivity disorder Autism Brain - pathology Brain Diseases - pathology Child Cortical thickness Estimates Female Humans Image Interpretation, Computer-Assisted - methods Imaging, Three-Dimensional - methods Magnetic Resonance Imaging - methods Male Middle Aged Motion Neuroanatomy Quality assurance Quality control Quantitative imaging Reproducibility of Results Schizophrenia Sensitivity and Specificity Sex Characteristics Sex Factors Software packages Studies Volumetry Websites Young Adult |
| title | Motion and morphometry in clinical and nonclinical populations |
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