CD8+CD103+ tumor-infiltrating lymphocytes are tumor-specific tissue-resident memory T cells and a prognostic factor for survival in lung cancer patients

We had previously demonstrated the role of CD103 integrin on lung tumor-infiltrating lymphocyte (TIL) clones in promoting specific TCR-mediated epithelial tumor cell cytotoxicity. However, the contribution of CD103 on intratumoral T cell distribution and functions and the prognosis significance of T...

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Veröffentlicht in:	The Journal of immunology (1950) 2015-04, Vol.194 (7), p.3475-3486
Hauptverfasser:	Djenidi, Fayçal, Adam, Julien, Goubar, Aïcha, Durgeau, Aurélie, Meurice, Guillaume, de Montpréville, Vincent, Validire, Pierre, Besse, Benjamin, Mami-Chouaib, Fathia
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Antigens, CD - metabolism Carcinoma, Non-Small-Cell Lung - immunology Carcinoma, Non-Small-Cell Lung - mortality Carcinoma, Non-Small-Cell Lung - pathology CD8 Antigens - metabolism Cytotoxicity, Immunologic Female Gene Expression Profiling Hepatitis A Virus Cellular Receptor 2 Humans Immunologic Memory Immunophenotyping Integrin alpha Chains - metabolism Lung Neoplasms - immunology Lung Neoplasms - mortality Lung Neoplasms - pathology Lymphocyte Activation - immunology Lymphocytes, Tumor-Infiltrating - immunology Lymphocytes, Tumor-Infiltrating - metabolism Male Membrane Proteins - genetics Membrane Proteins - metabolism Middle Aged Neoplasm Staging Organ Specificity - immunology Prognosis Programmed Cell Death 1 Receptor - genetics Programmed Cell Death 1 Receptor - metabolism Risk Factors
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