Prevalence of spondyloarthritis in reference to HLA-B27 in the French population: results of the GAZEL cohort
Objective To estimate the prevalence of spondyloarthritis (SpA) in reference to HLA-B27 in the French population. Methods In 1989, 20 625 employees of the French national gas and electricity company aged 35–50 years were enrolled in the GAZEL cohort. In 2010, 18 757 still active participants were sc...
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| Veröffentlicht in: | Annals of the rheumatic diseases 2015-04, Vol.74 (4), p.689-693 |
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| container_title | Annals of the rheumatic diseases |
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| creator | Costantino, Félicie Talpin, Alice Said-Nahal, Roula Goldberg, Marcel Henny, Joseph Chiocchia, Gilles Garchon, Henri-Jean Zins, Marie Breban, Maxime |
| description | Objective To estimate the prevalence of spondyloarthritis (SpA) in reference to HLA-B27 in the French population. Methods In 1989, 20 625 employees of the French national gas and electricity company aged 35–50 years were enrolled in the GAZEL cohort. In 2010, 18 757 still active participants were screened by a questionnaire validated for the detection of SpA. Responders with available DNA were retained for further studies. Pelvic radiograph and HLA-B27 typing were performed in all the self-reported cases of SpA or psoriatic arthritis. Self-reported diagnosis was verified by a qualified rheumatologist. HLA-B27 determination was also performed in subjects without any SpA feature. Results The target population consisted of 6556 responders with available DNA. Their male:female ratio was 3.6 and their mean age was 65.5±3.3 years. A diagnosis of SpA was confirmed in 32 of the 72 self-reported cases, 75% of them being HLA-B27 positive. Estimated SpA prevalence adjusted for sex was 0.43% (95% CI 0.26% to 0.70%). HLA-B27 positivity rate in 2466 healthy controls was 6.9% (95% CI 5.9% to 7.9%). The relative risk of SpA in HLA-B27 positive individuals was 39 (95% CI 17 to 86). Conclusions We estimated the prevalence of SpA in the French population in 2010 to 0.43%. With an estimated prevalence of 75.0% in SpA and 6.9% in healthy controls, HLA-B27 increased the disease risk 39-fold, as compared with HLA-B27 negative subjects. |
| doi_str_mv | 10.1136/annrheumdis-2013-204436 |
| format | Article |
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Methods In 1989, 20 625 employees of the French national gas and electricity company aged 35–50 years were enrolled in the GAZEL cohort. In 2010, 18 757 still active participants were screened by a questionnaire validated for the detection of SpA. Responders with available DNA were retained for further studies. Pelvic radiograph and HLA-B27 typing were performed in all the self-reported cases of SpA or psoriatic arthritis. Self-reported diagnosis was verified by a qualified rheumatologist. HLA-B27 determination was also performed in subjects without any SpA feature. Results The target population consisted of 6556 responders with available DNA. Their male:female ratio was 3.6 and their mean age was 65.5±3.3 years. A diagnosis of SpA was confirmed in 32 of the 72 self-reported cases, 75% of them being HLA-B27 positive. Estimated SpA prevalence adjusted for sex was 0.43% (95% CI 0.26% to 0.70%). HLA-B27 positivity rate in 2466 healthy controls was 6.9% (95% CI 5.9% to 7.9%). The relative risk of SpA in HLA-B27 positive individuals was 39 (95% CI 17 to 86). Conclusions We estimated the prevalence of SpA in the French population in 2010 to 0.43%. With an estimated prevalence of 75.0% in SpA and 6.9% in healthy controls, HLA-B27 increased the disease risk 39-fold, as compared with HLA-B27 negative subjects.</description><identifier>ISSN: 0003-4967</identifier><identifier>EISSN: 1468-2060</identifier><identifier>DOI: 10.1136/annrheumdis-2013-204436</identifier><identifier>PMID: 24351517</identifier><identifier>CODEN: ARDIAO</identifier><language>eng</language><publisher>England: Elsevier Limited</publisher><subject>Aged ; Arthritis ; Arthritis, Psoriatic - epidemiology ; Arthritis, Psoriatic - genetics ; Chronic illnesses ; Classification ; Cohort Studies ; Deoxyribonucleic acid ; DNA ; European Continental Ancestry Group - genetics ; Female ; France - epidemiology ; Genetic Predisposition to Disease ; Health care ; HLA-B27 Antigen - genetics ; Hospitals ; Humans ; Male ; Methods ; Middle Aged ; Mortality ; Population ; Prevalence ; Questionnaires ; Socioeconomic factors ; Spondylarthritis - epidemiology ; Spondylarthritis - genetics ; Studies ; Tumor necrosis factor-TNF</subject><ispartof>Annals of the rheumatic diseases, 2015-04, Vol.74 (4), p.689-693</ispartof><rights>Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions</rights><rights>Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.</rights><rights>Copyright: 2015 Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b553t-ff63af0c3a7ec7202ba7cdb40fc022e0e86056831430079aa81658de93a014533</citedby><cites>FETCH-LOGICAL-b553t-ff63af0c3a7ec7202ba7cdb40fc022e0e86056831430079aa81658de93a014533</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttp://ard.bmj.com/content/74/4/689.full.pdf$$EPDF$$P50$$Gbmj$$H</linktopdf><linktohtml>$$Uhttp://ard.bmj.com/content/74/4/689.full$$EHTML$$P50$$Gbmj$$H</linktohtml><link.rule.ids>114,115,314,776,780,3183,23550,27901,27902,77343,77374</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24351517$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Costantino, Félicie</creatorcontrib><creatorcontrib>Talpin, Alice</creatorcontrib><creatorcontrib>Said-Nahal, Roula</creatorcontrib><creatorcontrib>Goldberg, Marcel</creatorcontrib><creatorcontrib>Henny, Joseph</creatorcontrib><creatorcontrib>Chiocchia, Gilles</creatorcontrib><creatorcontrib>Garchon, Henri-Jean</creatorcontrib><creatorcontrib>Zins, Marie</creatorcontrib><creatorcontrib>Breban, Maxime</creatorcontrib><title>Prevalence of spondyloarthritis in reference to HLA-B27 in the French population: results of the GAZEL cohort</title><title>Annals of the rheumatic diseases</title><addtitle>Ann Rheum Dis</addtitle><description>Objective To estimate the prevalence of spondyloarthritis (SpA) in reference to HLA-B27 in the French population. Methods In 1989, 20 625 employees of the French national gas and electricity company aged 35–50 years were enrolled in the GAZEL cohort. In 2010, 18 757 still active participants were screened by a questionnaire validated for the detection of SpA. Responders with available DNA were retained for further studies. Pelvic radiograph and HLA-B27 typing were performed in all the self-reported cases of SpA or psoriatic arthritis. Self-reported diagnosis was verified by a qualified rheumatologist. HLA-B27 determination was also performed in subjects without any SpA feature. Results The target population consisted of 6556 responders with available DNA. Their male:female ratio was 3.6 and their mean age was 65.5±3.3 years. A diagnosis of SpA was confirmed in 32 of the 72 self-reported cases, 75% of them being HLA-B27 positive. Estimated SpA prevalence adjusted for sex was 0.43% (95% CI 0.26% to 0.70%). HLA-B27 positivity rate in 2466 healthy controls was 6.9% (95% CI 5.9% to 7.9%). The relative risk of SpA in HLA-B27 positive individuals was 39 (95% CI 17 to 86). Conclusions We estimated the prevalence of SpA in the French population in 2010 to 0.43%. With an estimated prevalence of 75.0% in SpA and 6.9% in healthy controls, HLA-B27 increased the disease risk 39-fold, as compared with HLA-B27 negative subjects.</description><subject>Aged</subject><subject>Arthritis</subject><subject>Arthritis, Psoriatic - epidemiology</subject><subject>Arthritis, Psoriatic - genetics</subject><subject>Chronic illnesses</subject><subject>Classification</subject><subject>Cohort Studies</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>European Continental Ancestry Group - genetics</subject><subject>Female</subject><subject>France - epidemiology</subject><subject>Genetic Predisposition to Disease</subject><subject>Health care</subject><subject>HLA-B27 Antigen - genetics</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Male</subject><subject>Methods</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Population</subject><subject>Prevalence</subject><subject>Questionnaires</subject><subject>Socioeconomic factors</subject><subject>Spondylarthritis - epidemiology</subject><subject>Spondylarthritis - genetics</subject><subject>Studies</subject><subject>Tumor necrosis factor-TNF</subject><issn>0003-4967</issn><issn>1468-2060</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNkU1r3DAQhkVJaDab_oXWkEsvbmYkW5J724Z8wUJyaC-5CNmWsRfbciQ5kH9fubspJZfmIjGaZx7QvIR8QfiGyPiFHkfXmnmoO59SQBaPLGP8A1lhxmWsOByRFQCwNCu4OCGn3u9iCRLlR3JCM5ZjjmJFhgdnnnVvxsoktkn8ZMf6pbfahdZ1ofNJNybONMb9IYJNbreb9AcVy3toTXK9NNpkstPc69DZ8XvE_dwHv-gW4mbzeLVNKttaF87IcaN7bz4d7jX5dX318_I23d7f3F1utmmZ5yykTcOZbqBiWphKUKClFlVdZtBUQKkBIznkXDLMGIAotJbIc1mbgmnALGdsTb7uvZOzT7PxQQ2dr0zf69HY2SuUIDmTnBb_RzlHRqMeI3r-Bt3Z2Y3xIwqFEAUUDHmkxJ6qnPU-7k5Nrhu0e1EIaglP_ROeWsJT-_Di5OeDfy4HU_-de00rAnQPlMPu3dbfnh-nVA</recordid><startdate>20150401</startdate><enddate>20150401</enddate><creator>Costantino, Félicie</creator><creator>Talpin, Alice</creator><creator>Said-Nahal, Roula</creator><creator>Goldberg, Marcel</creator><creator>Henny, Joseph</creator><creator>Chiocchia, Gilles</creator><creator>Garchon, Henri-Jean</creator><creator>Zins, Marie</creator><creator>Breban, Maxime</creator><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>LK8</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>20150401</creationdate><title>Prevalence of spondyloarthritis in reference to HLA-B27 in the French population: results of the GAZEL cohort</title><author>Costantino, Félicie ; Talpin, Alice ; Said-Nahal, Roula ; Goldberg, Marcel ; Henny, Joseph ; Chiocchia, Gilles ; Garchon, Henri-Jean ; Zins, Marie ; Breban, Maxime</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b553t-ff63af0c3a7ec7202ba7cdb40fc022e0e86056831430079aa81658de93a014533</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Aged</topic><topic>Arthritis</topic><topic>Arthritis, Psoriatic - epidemiology</topic><topic>Arthritis, Psoriatic - genetics</topic><topic>Chronic illnesses</topic><topic>Classification</topic><topic>Cohort Studies</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>European Continental Ancestry Group - genetics</topic><topic>Female</topic><topic>France - epidemiology</topic><topic>Genetic Predisposition to Disease</topic><topic>Health care</topic><topic>HLA-B27 Antigen - genetics</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Male</topic><topic>Methods</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Population</topic><topic>Prevalence</topic><topic>Questionnaires</topic><topic>Socioeconomic factors</topic><topic>Spondylarthritis - epidemiology</topic><topic>Spondylarthritis - genetics</topic><topic>Studies</topic><topic>Tumor necrosis factor-TNF</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Costantino, Félicie</creatorcontrib><creatorcontrib>Talpin, Alice</creatorcontrib><creatorcontrib>Said-Nahal, Roula</creatorcontrib><creatorcontrib>Goldberg, Marcel</creatorcontrib><creatorcontrib>Henny, Joseph</creatorcontrib><creatorcontrib>Chiocchia, Gilles</creatorcontrib><creatorcontrib>Garchon, Henri-Jean</creatorcontrib><creatorcontrib>Zins, Marie</creatorcontrib><creatorcontrib>Breban, Maxime</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Annals of the rheumatic diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Costantino, Félicie</au><au>Talpin, Alice</au><au>Said-Nahal, Roula</au><au>Goldberg, Marcel</au><au>Henny, Joseph</au><au>Chiocchia, Gilles</au><au>Garchon, Henri-Jean</au><au>Zins, Marie</au><au>Breban, Maxime</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevalence of spondyloarthritis in reference to HLA-B27 in the French population: results of the GAZEL cohort</atitle><jtitle>Annals of the rheumatic diseases</jtitle><addtitle>Ann Rheum Dis</addtitle><date>2015-04-01</date><risdate>2015</risdate><volume>74</volume><issue>4</issue><spage>689</spage><epage>693</epage><pages>689-693</pages><issn>0003-4967</issn><eissn>1468-2060</eissn><coden>ARDIAO</coden><abstract>Objective To estimate the prevalence of spondyloarthritis (SpA) in reference to HLA-B27 in the French population. Methods In 1989, 20 625 employees of the French national gas and electricity company aged 35–50 years were enrolled in the GAZEL cohort. In 2010, 18 757 still active participants were screened by a questionnaire validated for the detection of SpA. Responders with available DNA were retained for further studies. Pelvic radiograph and HLA-B27 typing were performed in all the self-reported cases of SpA or psoriatic arthritis. Self-reported diagnosis was verified by a qualified rheumatologist. HLA-B27 determination was also performed in subjects without any SpA feature. Results The target population consisted of 6556 responders with available DNA. Their male:female ratio was 3.6 and their mean age was 65.5±3.3 years. A diagnosis of SpA was confirmed in 32 of the 72 self-reported cases, 75% of them being HLA-B27 positive. Estimated SpA prevalence adjusted for sex was 0.43% (95% CI 0.26% to 0.70%). HLA-B27 positivity rate in 2466 healthy controls was 6.9% (95% CI 5.9% to 7.9%). The relative risk of SpA in HLA-B27 positive individuals was 39 (95% CI 17 to 86). Conclusions We estimated the prevalence of SpA in the French population in 2010 to 0.43%. With an estimated prevalence of 75.0% in SpA and 6.9% in healthy controls, HLA-B27 increased the disease risk 39-fold, as compared with HLA-B27 negative subjects.</abstract><cop>England</cop><pub>Elsevier Limited</pub><pmid>24351517</pmid><doi>10.1136/annrheumdis-2013-204436</doi><tpages>5</tpages></addata></record> |
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| ispartof | Annals of the rheumatic diseases, 2015-04, Vol.74 (4), p.689-693 |
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| subjects | Aged Arthritis Arthritis, Psoriatic - epidemiology Arthritis, Psoriatic - genetics Chronic illnesses Classification Cohort Studies Deoxyribonucleic acid DNA European Continental Ancestry Group - genetics Female France - epidemiology Genetic Predisposition to Disease Health care HLA-B27 Antigen - genetics Hospitals Humans Male Methods Middle Aged Mortality Population Prevalence Questionnaires Socioeconomic factors Spondylarthritis - epidemiology Spondylarthritis - genetics Studies Tumor necrosis factor-TNF |
| title | Prevalence of spondyloarthritis in reference to HLA-B27 in the French population: results of the GAZEL cohort |
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