Peripheral cannabinoid 1 receptor blockade activates brown adipose tissue and diminishes dyslipidemia and obesity

The endocannabinoid system is an important player in energy metabolism by regulating appetite, lipolysis, and energy expenditure. Chronic blockade of the cannabinoid 1 receptor (CB1R) leads to long‐term maintenance of weight loss and reduction of dyslipidemia in experimental and human obesity. The m...

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Veröffentlicht in:	The FASEB journal 2014-12, Vol.28 (12), p.5361-5375
Hauptverfasser:	Boon, Mariëtte R., Kooijman, Sander, Dam, Andrea D., Pelgrom, Leonard R., Berbée, Jimmy F. P., Visseren, Cheryl A. R., Aggele, Robin C., Hoek, Anita M., Sips, Hetty C. M., Lombès, Marc, Havekes, Louis M., Tamsma, Jouke T., Guigas, Bruno, Meijer, Onno C., Jukema, J. Wouter, Rensen, Patrick C. N.
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3-L1 Cells Absorptiometry, Photon Adipose Tissue, Brown - metabolism Animals Base Sequence DNA Primers Dyslipidemias - prevention & control Mice Mice, Transgenic Obesity - prevention & control Piperidines - pharmacology Pyrazoles - pharmacology Receptor, Cannabinoid, CB1 - antagonists & inhibitors Reverse Transcriptase Polymerase Chain Reaction rimonabant sympathetic nervous system uncoupling protein 1
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