Engagement of the Aryl Hydrocarbon Receptor in Mycobacterium tuberculosis-Infected Macrophages Has Pleiotropic Effects on Innate Immune Signaling

Understanding the mechanisms of host macrophage responses to Mycobacterium tuberculosis is essential for uncovering potential avenues of intervention to boost host resistance to infection. Macrophage transcriptome profiling revealed that M. tuberculosis infection strongly induced the expression of s...

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Veröffentlicht in:	The Journal of immunology (1950) 2015-11, Vol.195 (9), p.4479-4491
Hauptverfasser:	Memari, Babak, Bouttier, Manuella, Dimitrov, Vassil, Ouellette, Marc, Behr, Marcel A, Fritz, Jorg H, White, John H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blotting, Western Cell Line, Tumor Cells, Cultured Genetic Pleiotropy - immunology Host-Pathogen Interactions - immunology Humans Immunity, Innate - genetics Immunity, Innate - immunology Interleukin-22 Interleukin-23 - genetics Interleukin-23 - immunology Interleukin-23 - metabolism Interleukins - genetics Interleukins - immunology Interleukins - metabolism L Cells Macrophages - immunology Macrophages - metabolism Macrophages - microbiology Mice Microscopy, Fluorescence Mycobacterium tuberculosis Mycobacterium tuberculosis - immunology Mycobacterium tuberculosis - physiology Oligonucleotide Array Sequence Analysis Receptors, Aryl Hydrocarbon - genetics Receptors, Aryl Hydrocarbon - immunology Receptors, Aryl Hydrocarbon - metabolism RNA Interference Signal Transduction - genetics Signal Transduction - immunology Transcription Factor RelB - genetics Transcription Factor RelB - immunology Transcription Factor RelB - metabolism Transcriptome - genetics Transcriptome - immunology
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