Chronic helminth infection and helminth‐derived egg antigens promote adipose tissue M2 macrophages and improve insulin sensitivity in obese mice
ABSTRACT Chronic low‐grade inflammation associated with obesity contributes to insulin resistance and type 2 diabetes. Helminth parasites are the strongest natural inducers of type 2 immune responses, and short‐lived infection with rodent nematodes was reported to improve glucose tolerance in obese...
Gespeichert in:
| Veröffentlicht in: | The FASEB journal 2015-07, Vol.29 (7), p.3027-3039 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 3039 |
|---|---|
| container_issue | 7 |
| container_start_page | 3027 |
| container_title | The FASEB journal |
| container_volume | 29 |
| creator | Hussaarts, Leonie García‐Tardón, Noemí Beek, Lianne Heemskerk, Mattijs M. Haeberlein, Simone Zon, Gerard C. Ozir‐Fazalalikhan, Arifa Berbée, Jimmy F. P. Dijk, Ko Willems Harmelen, Vanessa Yazdanbakhsh, Maria Guigas, Bruno |
| description | ABSTRACT
Chronic low‐grade inflammation associated with obesity contributes to insulin resistance and type 2 diabetes. Helminth parasites are the strongest natural inducers of type 2 immune responses, and short‐lived infection with rodent nematodes was reported to improve glucose tolerance in obese mice. Here, we investigated the effects of chronic infection (12 weeks) with Schistosoma mansoni, a helminth that infects millions of humans worldwide, on whole‐body metabolic homeostasis and white adipose tissue (WAT) immune cell composition in high‐fat diet‐induced obese C57BL/6 male mice. Our data indicate that chronic helminth infection reduced body weight gain (‐62%), fat mass gain (‐89%), and adipocyte size; lowered whole‐body insulin resistance (‐23%) and glucose intolerance (‐16%); and improved peripheral glucose uptake (+25%) and WAT insulin sensitivity. Analysis of immune cell composition by flow cytometry and quantitative PCR (qPCR) revealed that S. mansoni promoted strong increases in WAT eosinophils and alternatively activated (M2) macrophages. Importantly, injections with S. mansonir‐soluble egg antigens (SEA) recapitulated the beneficial effect of parasite infection on whole‐body metabolic homeostasis and induced type 2 immune responses in WAT and liver. Taken together, we provide novel data suggesting that chronic helminth infection and helminth‐derived molecules protect against metabolic disorders by promoting a T helper 2 (Th2) response, eosinophilia, and WAT M2 polarization.—Hussaarts, L., García‐Tardón, N., van Beek, L., Heemskerk, M. M., Haeberlein, S., van der Zon, G. C., Ozir‐Fazalalikhan, A., Berbée, J. F. P., Willems van Dijk, K., van Harmelen, V., Yazdanbakhsh, M., Guigas, B. Chronic helminth infection and helminth‐derived egg antigens promote adipose tissue M2 macrophages and improve insulin sensitivity in obese mice. FASEB J. 29, 3027‐3039 (2015). www.fasebj.org |
| doi_str_mv | 10.1096/fj.14-266239 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1808637170</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1808637170</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3739-e5d3bca986bce643092a5768655e0e33051bc8ca485dc249caff42ebf98bea403</originalsourceid><addsrcrecordid>eNqNkU1vEzEQhi0Eomnhxhn5yIEt_l77CBGhoFY9AGfL651NJtqPsN4Nyo2fgPiJ_JIaEnpEPY0088yjGb2EvODskjNn3jTbS64KYYyQ7hFZcC1ZYaxhj8mCWScKY6Q9I-cpbRljnHHzlJwJbbVgSi3Ir-VmHHqMdANth_20odg3ECccehr6-r79-8fPGkbcQ01hvc6jCdfQJ7obh26YgIYad0MCOmFKM9AbQbsQx2G3CWtIf03YZXYP2Z_mFnua8jpOuMfpkHt0qCCvdxjhGXnShDbB81O9IF9X778sr4rr2w8fl2-viyhL6QrQtaxicNZUEYySzImgy_y51sBASqZ5FW0Myuo6CuViaBoloGqcrSAoJi_Iq6M33_VthjT5DlOEtg09DHPy3DJrZMnLB6DGSW6VE2VGXx_R_H1KIzR-N2IXxoPnzP8JzDdbz5U_BpbxlyfzXHVQ38P_EsqAPQLfsYXDf2V-9fmdWH3i6uS-AwnvpaA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1693184927</pqid></control><display><type>article</type><title>Chronic helminth infection and helminth‐derived egg antigens promote adipose tissue M2 macrophages and improve insulin sensitivity in obese mice</title><source>MEDLINE</source><source>Wiley Online Library All Journals</source><source>Alma/SFX Local Collection</source><creator>Hussaarts, Leonie ; García‐Tardón, Noemí ; Beek, Lianne ; Heemskerk, Mattijs M. ; Haeberlein, Simone ; Zon, Gerard C. ; Ozir‐Fazalalikhan, Arifa ; Berbée, Jimmy F. P. ; Dijk, Ko Willems ; Harmelen, Vanessa ; Yazdanbakhsh, Maria ; Guigas, Bruno</creator><creatorcontrib>Hussaarts, Leonie ; García‐Tardón, Noemí ; Beek, Lianne ; Heemskerk, Mattijs M. ; Haeberlein, Simone ; Zon, Gerard C. ; Ozir‐Fazalalikhan, Arifa ; Berbée, Jimmy F. P. ; Dijk, Ko Willems ; Harmelen, Vanessa ; Yazdanbakhsh, Maria ; Guigas, Bruno</creatorcontrib><description>ABSTRACT
Chronic low‐grade inflammation associated with obesity contributes to insulin resistance and type 2 diabetes. Helminth parasites are the strongest natural inducers of type 2 immune responses, and short‐lived infection with rodent nematodes was reported to improve glucose tolerance in obese mice. Here, we investigated the effects of chronic infection (12 weeks) with Schistosoma mansoni, a helminth that infects millions of humans worldwide, on whole‐body metabolic homeostasis and white adipose tissue (WAT) immune cell composition in high‐fat diet‐induced obese C57BL/6 male mice. Our data indicate that chronic helminth infection reduced body weight gain (‐62%), fat mass gain (‐89%), and adipocyte size; lowered whole‐body insulin resistance (‐23%) and glucose intolerance (‐16%); and improved peripheral glucose uptake (+25%) and WAT insulin sensitivity. Analysis of immune cell composition by flow cytometry and quantitative PCR (qPCR) revealed that S. mansoni promoted strong increases in WAT eosinophils and alternatively activated (M2) macrophages. Importantly, injections with S. mansonir‐soluble egg antigens (SEA) recapitulated the beneficial effect of parasite infection on whole‐body metabolic homeostasis and induced type 2 immune responses in WAT and liver. Taken together, we provide novel data suggesting that chronic helminth infection and helminth‐derived molecules protect against metabolic disorders by promoting a T helper 2 (Th2) response, eosinophilia, and WAT M2 polarization.—Hussaarts, L., García‐Tardón, N., van Beek, L., Heemskerk, M. M., Haeberlein, S., van der Zon, G. C., Ozir‐Fazalalikhan, A., Berbée, J. F. P., Willems van Dijk, K., van Harmelen, V., Yazdanbakhsh, M., Guigas, B. Chronic helminth infection and helminth‐derived egg antigens promote adipose tissue M2 macrophages and improve insulin sensitivity in obese mice. FASEB J. 29, 3027‐3039 (2015). www.fasebj.org</description><identifier>ISSN: 0892-6638</identifier><identifier>EISSN: 1530-6860</identifier><identifier>DOI: 10.1096/fj.14-266239</identifier><identifier>PMID: 25852044</identifier><language>eng</language><publisher>United States: Federation of American Societies for Experimental Biology</publisher><subject>Adipose Tissue, White - immunology ; Adipose Tissue, White - pathology ; Animals ; Antigens, Helminth - administration & dosage ; Chronic Disease ; Diet, High-Fat - adverse effects ; Disease Models, Animal ; eosinophils ; Eosinophils - immunology ; Female ; Glucose Tolerance Test ; Humans ; immunometabolism ; Insulin Resistance - immunology ; Insulin Resistance - physiology ; Liver - immunology ; Macrophage Activation ; Male ; Mice ; Mice, Inbred C57BL ; Nematoda ; Obesity - complications ; Obesity - immunology ; Obesity - metabolism ; Schistosoma mansoni ; Schistosoma mansoni - immunology ; Schistosomiasis mansoni - complications ; Schistosomiasis mansoni - immunology ; Schistosomiasis mansoni - metabolism ; Th2 Cells - immunology ; type 2 inflammation</subject><ispartof>The FASEB journal, 2015-07, Vol.29 (7), p.3027-3039</ispartof><rights>FASEB</rights><rights>FASEB.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3739-e5d3bca986bce643092a5768655e0e33051bc8ca485dc249caff42ebf98bea403</citedby><cites>FETCH-LOGICAL-c3739-e5d3bca986bce643092a5768655e0e33051bc8ca485dc249caff42ebf98bea403</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1096%2Ffj.14-266239$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1096%2Ffj.14-266239$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25852044$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hussaarts, Leonie</creatorcontrib><creatorcontrib>García‐Tardón, Noemí</creatorcontrib><creatorcontrib>Beek, Lianne</creatorcontrib><creatorcontrib>Heemskerk, Mattijs M.</creatorcontrib><creatorcontrib>Haeberlein, Simone</creatorcontrib><creatorcontrib>Zon, Gerard C.</creatorcontrib><creatorcontrib>Ozir‐Fazalalikhan, Arifa</creatorcontrib><creatorcontrib>Berbée, Jimmy F. P.</creatorcontrib><creatorcontrib>Dijk, Ko Willems</creatorcontrib><creatorcontrib>Harmelen, Vanessa</creatorcontrib><creatorcontrib>Yazdanbakhsh, Maria</creatorcontrib><creatorcontrib>Guigas, Bruno</creatorcontrib><title>Chronic helminth infection and helminth‐derived egg antigens promote adipose tissue M2 macrophages and improve insulin sensitivity in obese mice</title><title>The FASEB journal</title><addtitle>FASEB J</addtitle><description>ABSTRACT
Chronic low‐grade inflammation associated with obesity contributes to insulin resistance and type 2 diabetes. Helminth parasites are the strongest natural inducers of type 2 immune responses, and short‐lived infection with rodent nematodes was reported to improve glucose tolerance in obese mice. Here, we investigated the effects of chronic infection (12 weeks) with Schistosoma mansoni, a helminth that infects millions of humans worldwide, on whole‐body metabolic homeostasis and white adipose tissue (WAT) immune cell composition in high‐fat diet‐induced obese C57BL/6 male mice. Our data indicate that chronic helminth infection reduced body weight gain (‐62%), fat mass gain (‐89%), and adipocyte size; lowered whole‐body insulin resistance (‐23%) and glucose intolerance (‐16%); and improved peripheral glucose uptake (+25%) and WAT insulin sensitivity. Analysis of immune cell composition by flow cytometry and quantitative PCR (qPCR) revealed that S. mansoni promoted strong increases in WAT eosinophils and alternatively activated (M2) macrophages. Importantly, injections with S. mansonir‐soluble egg antigens (SEA) recapitulated the beneficial effect of parasite infection on whole‐body metabolic homeostasis and induced type 2 immune responses in WAT and liver. Taken together, we provide novel data suggesting that chronic helminth infection and helminth‐derived molecules protect against metabolic disorders by promoting a T helper 2 (Th2) response, eosinophilia, and WAT M2 polarization.—Hussaarts, L., García‐Tardón, N., van Beek, L., Heemskerk, M. M., Haeberlein, S., van der Zon, G. C., Ozir‐Fazalalikhan, A., Berbée, J. F. P., Willems van Dijk, K., van Harmelen, V., Yazdanbakhsh, M., Guigas, B. Chronic helminth infection and helminth‐derived egg antigens promote adipose tissue M2 macrophages and improve insulin sensitivity in obese mice. FASEB J. 29, 3027‐3039 (2015). www.fasebj.org</description><subject>Adipose Tissue, White - immunology</subject><subject>Adipose Tissue, White - pathology</subject><subject>Animals</subject><subject>Antigens, Helminth - administration & dosage</subject><subject>Chronic Disease</subject><subject>Diet, High-Fat - adverse effects</subject><subject>Disease Models, Animal</subject><subject>eosinophils</subject><subject>Eosinophils - immunology</subject><subject>Female</subject><subject>Glucose Tolerance Test</subject><subject>Humans</subject><subject>immunometabolism</subject><subject>Insulin Resistance - immunology</subject><subject>Insulin Resistance - physiology</subject><subject>Liver - immunology</subject><subject>Macrophage Activation</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Nematoda</subject><subject>Obesity - complications</subject><subject>Obesity - immunology</subject><subject>Obesity - metabolism</subject><subject>Schistosoma mansoni</subject><subject>Schistosoma mansoni - immunology</subject><subject>Schistosomiasis mansoni - complications</subject><subject>Schistosomiasis mansoni - immunology</subject><subject>Schistosomiasis mansoni - metabolism</subject><subject>Th2 Cells - immunology</subject><subject>type 2 inflammation</subject><issn>0892-6638</issn><issn>1530-6860</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU1vEzEQhi0Eomnhxhn5yIEt_l77CBGhoFY9AGfL651NJtqPsN4Nyo2fgPiJ_JIaEnpEPY0088yjGb2EvODskjNn3jTbS64KYYyQ7hFZcC1ZYaxhj8mCWScKY6Q9I-cpbRljnHHzlJwJbbVgSi3Ir-VmHHqMdANth_20odg3ECccehr6-r79-8fPGkbcQ01hvc6jCdfQJ7obh26YgIYad0MCOmFKM9AbQbsQx2G3CWtIf03YZXYP2Z_mFnua8jpOuMfpkHt0qCCvdxjhGXnShDbB81O9IF9X778sr4rr2w8fl2-viyhL6QrQtaxicNZUEYySzImgy_y51sBASqZ5FW0Myuo6CuViaBoloGqcrSAoJi_Iq6M33_VthjT5DlOEtg09DHPy3DJrZMnLB6DGSW6VE2VGXx_R_H1KIzR-N2IXxoPnzP8JzDdbz5U_BpbxlyfzXHVQ38P_EsqAPQLfsYXDf2V-9fmdWH3i6uS-AwnvpaA</recordid><startdate>201507</startdate><enddate>201507</enddate><creator>Hussaarts, Leonie</creator><creator>García‐Tardón, Noemí</creator><creator>Beek, Lianne</creator><creator>Heemskerk, Mattijs M.</creator><creator>Haeberlein, Simone</creator><creator>Zon, Gerard C.</creator><creator>Ozir‐Fazalalikhan, Arifa</creator><creator>Berbée, Jimmy F. P.</creator><creator>Dijk, Ko Willems</creator><creator>Harmelen, Vanessa</creator><creator>Yazdanbakhsh, Maria</creator><creator>Guigas, Bruno</creator><general>Federation of American Societies for Experimental Biology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>7U7</scope><scope>C1K</scope><scope>H94</scope></search><sort><creationdate>201507</creationdate><title>Chronic helminth infection and helminth‐derived egg antigens promote adipose tissue M2 macrophages and improve insulin sensitivity in obese mice</title><author>Hussaarts, Leonie ; García‐Tardón, Noemí ; Beek, Lianne ; Heemskerk, Mattijs M. ; Haeberlein, Simone ; Zon, Gerard C. ; Ozir‐Fazalalikhan, Arifa ; Berbée, Jimmy F. P. ; Dijk, Ko Willems ; Harmelen, Vanessa ; Yazdanbakhsh, Maria ; Guigas, Bruno</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3739-e5d3bca986bce643092a5768655e0e33051bc8ca485dc249caff42ebf98bea403</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adipose Tissue, White - immunology</topic><topic>Adipose Tissue, White - pathology</topic><topic>Animals</topic><topic>Antigens, Helminth - administration & dosage</topic><topic>Chronic Disease</topic><topic>Diet, High-Fat - adverse effects</topic><topic>Disease Models, Animal</topic><topic>eosinophils</topic><topic>Eosinophils - immunology</topic><topic>Female</topic><topic>Glucose Tolerance Test</topic><topic>Humans</topic><topic>immunometabolism</topic><topic>Insulin Resistance - immunology</topic><topic>Insulin Resistance - physiology</topic><topic>Liver - immunology</topic><topic>Macrophage Activation</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Nematoda</topic><topic>Obesity - complications</topic><topic>Obesity - immunology</topic><topic>Obesity - metabolism</topic><topic>Schistosoma mansoni</topic><topic>Schistosoma mansoni - immunology</topic><topic>Schistosomiasis mansoni - complications</topic><topic>Schistosomiasis mansoni - immunology</topic><topic>Schistosomiasis mansoni - metabolism</topic><topic>Th2 Cells - immunology</topic><topic>type 2 inflammation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hussaarts, Leonie</creatorcontrib><creatorcontrib>García‐Tardón, Noemí</creatorcontrib><creatorcontrib>Beek, Lianne</creatorcontrib><creatorcontrib>Heemskerk, Mattijs M.</creatorcontrib><creatorcontrib>Haeberlein, Simone</creatorcontrib><creatorcontrib>Zon, Gerard C.</creatorcontrib><creatorcontrib>Ozir‐Fazalalikhan, Arifa</creatorcontrib><creatorcontrib>Berbée, Jimmy F. P.</creatorcontrib><creatorcontrib>Dijk, Ko Willems</creatorcontrib><creatorcontrib>Harmelen, Vanessa</creatorcontrib><creatorcontrib>Yazdanbakhsh, Maria</creatorcontrib><creatorcontrib>Guigas, Bruno</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>The FASEB journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hussaarts, Leonie</au><au>García‐Tardón, Noemí</au><au>Beek, Lianne</au><au>Heemskerk, Mattijs M.</au><au>Haeberlein, Simone</au><au>Zon, Gerard C.</au><au>Ozir‐Fazalalikhan, Arifa</au><au>Berbée, Jimmy F. P.</au><au>Dijk, Ko Willems</au><au>Harmelen, Vanessa</au><au>Yazdanbakhsh, Maria</au><au>Guigas, Bruno</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chronic helminth infection and helminth‐derived egg antigens promote adipose tissue M2 macrophages and improve insulin sensitivity in obese mice</atitle><jtitle>The FASEB journal</jtitle><addtitle>FASEB J</addtitle><date>2015-07</date><risdate>2015</risdate><volume>29</volume><issue>7</issue><spage>3027</spage><epage>3039</epage><pages>3027-3039</pages><issn>0892-6638</issn><eissn>1530-6860</eissn><abstract>ABSTRACT
Chronic low‐grade inflammation associated with obesity contributes to insulin resistance and type 2 diabetes. Helminth parasites are the strongest natural inducers of type 2 immune responses, and short‐lived infection with rodent nematodes was reported to improve glucose tolerance in obese mice. Here, we investigated the effects of chronic infection (12 weeks) with Schistosoma mansoni, a helminth that infects millions of humans worldwide, on whole‐body metabolic homeostasis and white adipose tissue (WAT) immune cell composition in high‐fat diet‐induced obese C57BL/6 male mice. Our data indicate that chronic helminth infection reduced body weight gain (‐62%), fat mass gain (‐89%), and adipocyte size; lowered whole‐body insulin resistance (‐23%) and glucose intolerance (‐16%); and improved peripheral glucose uptake (+25%) and WAT insulin sensitivity. Analysis of immune cell composition by flow cytometry and quantitative PCR (qPCR) revealed that S. mansoni promoted strong increases in WAT eosinophils and alternatively activated (M2) macrophages. Importantly, injections with S. mansonir‐soluble egg antigens (SEA) recapitulated the beneficial effect of parasite infection on whole‐body metabolic homeostasis and induced type 2 immune responses in WAT and liver. Taken together, we provide novel data suggesting that chronic helminth infection and helminth‐derived molecules protect against metabolic disorders by promoting a T helper 2 (Th2) response, eosinophilia, and WAT M2 polarization.—Hussaarts, L., García‐Tardón, N., van Beek, L., Heemskerk, M. M., Haeberlein, S., van der Zon, G. C., Ozir‐Fazalalikhan, A., Berbée, J. F. P., Willems van Dijk, K., van Harmelen, V., Yazdanbakhsh, M., Guigas, B. Chronic helminth infection and helminth‐derived egg antigens promote adipose tissue M2 macrophages and improve insulin sensitivity in obese mice. FASEB J. 29, 3027‐3039 (2015). www.fasebj.org</abstract><cop>United States</cop><pub>Federation of American Societies for Experimental Biology</pub><pmid>25852044</pmid><doi>10.1096/fj.14-266239</doi><tpages>13</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0892-6638 |
| ispartof | The FASEB journal, 2015-07, Vol.29 (7), p.3027-3039 |
| issn | 0892-6638 1530-6860 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1808637170 |
| source | MEDLINE; Wiley Online Library All Journals; Alma/SFX Local Collection |
| subjects | Adipose Tissue, White - immunology Adipose Tissue, White - pathology Animals Antigens, Helminth - administration & dosage Chronic Disease Diet, High-Fat - adverse effects Disease Models, Animal eosinophils Eosinophils - immunology Female Glucose Tolerance Test Humans immunometabolism Insulin Resistance - immunology Insulin Resistance - physiology Liver - immunology Macrophage Activation Male Mice Mice, Inbred C57BL Nematoda Obesity - complications Obesity - immunology Obesity - metabolism Schistosoma mansoni Schistosoma mansoni - immunology Schistosomiasis mansoni - complications Schistosomiasis mansoni - immunology Schistosomiasis mansoni - metabolism Th2 Cells - immunology type 2 inflammation |
| title | Chronic helminth infection and helminth‐derived egg antigens promote adipose tissue M2 macrophages and improve insulin sensitivity in obese mice |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-17T13%3A32%3A34IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Chronic%20helminth%20infection%20and%20helminth%E2%80%90derived%20egg%20antigens%20promote%20adipose%20tissue%20M2%20macrophages%20and%20improve%20insulin%20sensitivity%20in%20obese%20mice&rft.jtitle=The%20FASEB%20journal&rft.au=Hussaarts,%20Leonie&rft.date=2015-07&rft.volume=29&rft.issue=7&rft.spage=3027&rft.epage=3039&rft.pages=3027-3039&rft.issn=0892-6638&rft.eissn=1530-6860&rft_id=info:doi/10.1096/fj.14-266239&rft_dat=%3Cproquest_cross%3E1808637170%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1693184927&rft_id=info:pmid/25852044&rfr_iscdi=true |