Inhibition of the pontine Kölliker-Fuse nucleus reduces genioglossal activity elicited by stimulation of the retrotrapezoid chemoreceptor neurons
Highlights • Stimulation of central chemoreflex elicits an increase in genioglossal EMG activity. • Histological evidence for glutamatergic and GABAergic inputs to the KF region from RTN chemoreceptors. • Inhibition in KF region abolishes the GG response due to increased RTN activity. • KF integrate...
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| Veröffentlicht in: | Neuroscience 2016-07, Vol.328, p.9-21 |
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| creator | Silva, Josiane N Lucena, Elvis V Silva, Talita M Damasceno, Rosélia S Takakura, Ana C Moreira, Thiago S |
| description | Highlights • Stimulation of central chemoreflex elicits an increase in genioglossal EMG activity. • Histological evidence for glutamatergic and GABAergic inputs to the KF region from RTN chemoreceptors. • Inhibition in KF region abolishes the GG response due to increased RTN activity. • KF integrates and modulates breathing during chemoreceptor activation. |
| doi_str_mv | 10.1016/j.neuroscience.2016.04.028 |
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Lucena, Elvis V ; Silva, Talita M ; Damasceno, Rosélia S ; Takakura, Ana C ; Moreira, Thiago S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c468t-a48a255bb09364782ce37f96402b141c8ad13f7eec81ab068d319642f3da211d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Animals</topic><topic>breathing</topic><topic>Chemoreceptor Cells - cytology</topic><topic>Chemoreceptor Cells - physiology</topic><topic>chemoreflex</topic><topic>Diaphragm - innervation</topic><topic>Diaphragm - physiology</topic><topic>dorsolateral pons</topic><topic>genioglossal activity</topic><topic>Glutamate Decarboxylase - metabolism</topic><topic>Glutamic Acid - metabolism</topic><topic>Hypercapnia - pathology</topic><topic>Hypercapnia - physiopathology</topic><topic>Male</topic><topic>Medulla Oblongata - cytology</topic><topic>Medulla Oblongata - physiology</topic><topic>Muscimol - pharmacology</topic><topic>N-Methylaspartate - pharmacology</topic><topic>Neurology</topic><topic>Neurotransmitter Agents - pharmacology</topic><topic>Pons - cytology</topic><topic>Pons - drug effects</topic><topic>Pons - physiology</topic><topic>Rats, Wistar</topic><topic>Receptors, GABA-A - metabolism</topic><topic>Receptors, N-Methyl-D-Aspartate - metabolism</topic><topic>Respiration - drug effects</topic><topic>Tongue - innervation</topic><topic>Tongue - physiology</topic><topic>ventrolateral medulla</topic><topic>Vesicular Glutamate Transport Protein 2 - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Silva, Josiane N</creatorcontrib><creatorcontrib>Lucena, Elvis V</creatorcontrib><creatorcontrib>Silva, Talita M</creatorcontrib><creatorcontrib>Damasceno, Rosélia S</creatorcontrib><creatorcontrib>Takakura, Ana C</creatorcontrib><creatorcontrib>Moreira, Thiago S</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Silva, Josiane N</au><au>Lucena, Elvis V</au><au>Silva, Talita M</au><au>Damasceno, Rosélia S</au><au>Takakura, Ana C</au><au>Moreira, Thiago S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inhibition of the pontine Kölliker-Fuse nucleus reduces genioglossal activity elicited by stimulation of the retrotrapezoid chemoreceptor neurons</atitle><jtitle>Neuroscience</jtitle><addtitle>Neuroscience</addtitle><date>2016-07-22</date><risdate>2016</risdate><volume>328</volume><spage>9</spage><epage>21</epage><pages>9-21</pages><issn>0306-4522</issn><eissn>1873-7544</eissn><abstract>Highlights • Stimulation of central chemoreflex elicits an increase in genioglossal EMG activity. • Histological evidence for glutamatergic and GABAergic inputs to the KF region from RTN chemoreceptors. • Inhibition in KF region abolishes the GG response due to increased RTN activity. • KF integrates and modulates breathing during chemoreceptor activation.</abstract><cop>United States</cop><pub>Elsevier Ltd</pub><pmid>27126558</pmid><doi>10.1016/j.neuroscience.2016.04.028</doi><tpages>13</tpages></addata></record> |
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| subjects | Animals breathing Chemoreceptor Cells - cytology Chemoreceptor Cells - physiology chemoreflex Diaphragm - innervation Diaphragm - physiology dorsolateral pons genioglossal activity Glutamate Decarboxylase - metabolism Glutamic Acid - metabolism Hypercapnia - pathology Hypercapnia - physiopathology Male Medulla Oblongata - cytology Medulla Oblongata - physiology Muscimol - pharmacology N-Methylaspartate - pharmacology Neurology Neurotransmitter Agents - pharmacology Pons - cytology Pons - drug effects Pons - physiology Rats, Wistar Receptors, GABA-A - metabolism Receptors, N-Methyl-D-Aspartate - metabolism Respiration - drug effects Tongue - innervation Tongue - physiology ventrolateral medulla Vesicular Glutamate Transport Protein 2 - metabolism |
| title | Inhibition of the pontine Kölliker-Fuse nucleus reduces genioglossal activity elicited by stimulation of the retrotrapezoid chemoreceptor neurons |
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