Inhibition of the pontine Kölliker-Fuse nucleus reduces genioglossal activity elicited by stimulation of the retrotrapezoid chemoreceptor neurons

Highlights • Stimulation of central chemoreflex elicits an increase in genioglossal EMG activity. • Histological evidence for glutamatergic and GABAergic inputs to the KF region from RTN chemoreceptors. • Inhibition in KF region abolishes the GG response due to increased RTN activity. • KF integrate...

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Veröffentlicht in:	Neuroscience 2016-07, Vol.328, p.9-21
Hauptverfasser:	Silva, Josiane N, Lucena, Elvis V, Silva, Talita M, Damasceno, Rosélia S, Takakura, Ana C, Moreira, Thiago S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals breathing Chemoreceptor Cells - cytology Chemoreceptor Cells - physiology chemoreflex Diaphragm - innervation Diaphragm - physiology dorsolateral pons genioglossal activity Glutamate Decarboxylase - metabolism Glutamic Acid - metabolism Hypercapnia - pathology Hypercapnia - physiopathology Male Medulla Oblongata - cytology Medulla Oblongata - physiology Muscimol - pharmacology N-Methylaspartate - pharmacology Neurology Neurotransmitter Agents - pharmacology Pons - cytology Pons - drug effects Pons - physiology Rats, Wistar Receptors, GABA-A - metabolism Receptors, N-Methyl-D-Aspartate - metabolism Respiration - drug effects Tongue - innervation Tongue - physiology ventrolateral medulla Vesicular Glutamate Transport Protein 2 - metabolism
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Zusammenfassung:	Highlights • Stimulation of central chemoreflex elicits an increase in genioglossal EMG activity. • Histological evidence for glutamatergic and GABAergic inputs to the KF region from RTN chemoreceptors. • Inhibition in KF region abolishes the GG response due to increased RTN activity. • KF integrates and modulates breathing during chemoreceptor activation.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2016.04.028