Dissipative self-assembly of vesicular nanoreactors
Dissipative self-assembly is exploited by nature to control important biological functions, such as cell division, motility and signal transduction. The ability to construct synthetic supramolecular assemblies that require the continuous consumption of energy to remain in the functional state is an...
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| Veröffentlicht in: | Nature chemistry 2016-07, Vol.8 (7), p.725-731 |
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| creator | Maiti, Subhabrata Fortunati, Ilaria Ferrante, Camilla Scrimin, Paolo Prins, Leonard J. |
| description | Dissipative self-assembly is exploited by nature to control important biological functions, such as cell division, motility and signal transduction. The ability to construct synthetic supramolecular assemblies that require the continuous consumption of energy to remain in the functional state is an essential premise for the design of synthetic systems with lifelike properties. Here, we show a new strategy for the dissipative self-assembly of functional supramolecular structures with high structural complexity. It relies on the transient stabilization of vesicles through noncovalent interactions between the surfactants and adenosine triphosphate (ATP), which acts as the chemical fuel. It is shown that the lifetime of the vesicles can be regulated by controlling the hydrolysis rate of ATP. The vesicles sustain a chemical reaction but only as long as chemical fuel is present to keep the system in the out-of-equilibrium state. The lifetime of the vesicles determines the amount of reaction product produced by the system.
Dissipative self-assembly processes are energetically uphill and require the continuous consumption of energy. Now, by using ATP as a chemical fuel, the dissipative self-assembly of vesicles has been demonstrated. These transiently formed supramolecular assemblies are able to sustain a chemical reaction and it is shown that the yield depends on the lifetime of the vesicles. |
| doi_str_mv | 10.1038/nchem.2511 |
| format | Article |
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Dissipative self-assembly processes are energetically uphill and require the continuous consumption of energy. Now, by using ATP as a chemical fuel, the dissipative self-assembly of vesicles has been demonstrated. These transiently formed supramolecular assemblies are able to sustain a chemical reaction and it is shown that the yield depends on the lifetime of the vesicles.</description><identifier>ISSN: 1755-4330</identifier><identifier>EISSN: 1755-4349</identifier><identifier>DOI: 10.1038/nchem.2511</identifier><identifier>PMID: 27325101</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>639/638/298/923/966 ; 639/638/403 ; 639/638/541/966 ; 639/638/549 ; 639/925/357/341 ; Adenosine triphosphate ; Analytical Chemistry ; ATP ; Biochemistry ; Cell division ; Chemical fuels ; Chemical reactions ; Chemistry ; Chemistry/Food Science ; Energy consumption ; Energy dissipation ; Inorganic Chemistry ; Nuclear fuels ; Organic Chemistry ; Physical Chemistry ; Self-assembly ; Signal transduction ; Vesicles</subject><ispartof>Nature chemistry, 2016-07, Vol.8 (7), p.725-731</ispartof><rights>Springer Nature Limited 2016</rights><rights>Copyright Nature Publishing Group Jul 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c487t-8dd5896811890ea402c4f2dbcf9185821b273c603cdc6bf664fb14c0a98201a13</citedby><cites>FETCH-LOGICAL-c487t-8dd5896811890ea402c4f2dbcf9185821b273c603cdc6bf664fb14c0a98201a13</cites><orcidid>0000-0002-2554-0762 ; 0000-0001-6664-822X ; 0000-0002-6741-3374</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27325101$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Maiti, Subhabrata</creatorcontrib><creatorcontrib>Fortunati, Ilaria</creatorcontrib><creatorcontrib>Ferrante, Camilla</creatorcontrib><creatorcontrib>Scrimin, Paolo</creatorcontrib><creatorcontrib>Prins, Leonard J.</creatorcontrib><title>Dissipative self-assembly of vesicular nanoreactors</title><title>Nature chemistry</title><addtitle>Nature Chem</addtitle><addtitle>Nat Chem</addtitle><description>Dissipative self-assembly is exploited by nature to control important biological functions, such as cell division, motility and signal transduction. The ability to construct synthetic supramolecular assemblies that require the continuous consumption of energy to remain in the functional state is an essential premise for the design of synthetic systems with lifelike properties. Here, we show a new strategy for the dissipative self-assembly of functional supramolecular structures with high structural complexity. It relies on the transient stabilization of vesicles through noncovalent interactions between the surfactants and adenosine triphosphate (ATP), which acts as the chemical fuel. It is shown that the lifetime of the vesicles can be regulated by controlling the hydrolysis rate of ATP. The vesicles sustain a chemical reaction but only as long as chemical fuel is present to keep the system in the out-of-equilibrium state. The lifetime of the vesicles determines the amount of reaction product produced by the system.
Dissipative self-assembly processes are energetically uphill and require the continuous consumption of energy. Now, by using ATP as a chemical fuel, the dissipative self-assembly of vesicles has been demonstrated. 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Dissipative self-assembly processes are energetically uphill and require the continuous consumption of energy. Now, by using ATP as a chemical fuel, the dissipative self-assembly of vesicles has been demonstrated. These transiently formed supramolecular assemblies are able to sustain a chemical reaction and it is shown that the yield depends on the lifetime of the vesicles.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>27325101</pmid><doi>10.1038/nchem.2511</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-2554-0762</orcidid><orcidid>https://orcid.org/0000-0001-6664-822X</orcidid><orcidid>https://orcid.org/0000-0002-6741-3374</orcidid></addata></record> |
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| subjects | 639/638/298/923/966 639/638/403 639/638/541/966 639/638/549 639/925/357/341 Adenosine triphosphate Analytical Chemistry ATP Biochemistry Cell division Chemical fuels Chemical reactions Chemistry Chemistry/Food Science Energy consumption Energy dissipation Inorganic Chemistry Nuclear fuels Organic Chemistry Physical Chemistry Self-assembly Signal transduction Vesicles |
| title | Dissipative self-assembly of vesicular nanoreactors |
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