Role of IL-4 receptor α–positive CD4+ T cells in chronic airway hyperresponsiveness

Background TH 2 cells and their cytokines are associated with allergic asthma in human subjects and with mouse models of allergic airway disease. IL-4 signaling through the IL-4 receptor α (IL-4Rα) chain on CD4+ T cells leads to TH 2 cell differentiation in vitro , implying that IL-4Rα–responsive CD...

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Veröffentlicht in:	Journal of allergy and clinical immunology 2016-06, Vol.137 (6), p.1852-1862.e9
Hauptverfasser:	Kirstein, Frank, PhD, Nieuwenhuizen, Natalie E., PhD, Jayakumar, Jaisubash, PhD, Horsnell, William G.C., PhD, Brombacher, Frank, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	acute allergic airway disease Allergy and Immunology Animals Asthma - genetics Asthma - immunology Asthma - metabolism CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - metabolism chronic asthma Chronic Disease cytokine receptors Cytokines - metabolism Disease Models, Animal Female gene-deficient mice Humans IL-13 IL-4 Immunoglobulin E - blood Immunoglobulin E - immunology Immunoglobulin G - blood Immunoglobulin G - immunology Interleukin-4 Receptor alpha Subunit - genetics Interleukin-4 Receptor alpha Subunit - metabolism Leukocyte Count Mice Mice, Knockout Ovalbumin - immunology Respiratory Hypersensitivity - genetics Respiratory Hypersensitivity - immunology Respiratory Hypersensitivity - metabolism Respiratory Hypersensitivity - physiopathology T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - metabolism TH2 cell Th2 Cells - immunology Th2 Cells - metabolism
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