Regional Differences in Prevalence of Macrolide Resistance among Pediatric Mycoplasma pneumoniae Infections in Hokkaido, Japan
Recently, macrolide-resistant (MR) Mycoplasma pneumonia appeared, and prevalence of macrolide resistance among M. pneumoniae infections varies by country. However, reports on regional differences in the prevalence of MR M. pneumonia within a country are scarce. In this study, 617 nasopharyngeal swab...
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| Veröffentlicht in: | Japanese Journal of Infectious Diseases 2016, Vol.69(3), pp.186-190 |
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| creator | Ishiguro, Nobuhisa Koseki, Naoko Kaiho, Miki Kikuta, Hideaki Togashi, Takehiro Oba, Koji Morita, Keisuke Nagano, Naoko Nakanishi, Masanori Hazama, Kyosuke Watanabe, Toru Sasaki, Satoshi Horino, Atsuko Kenri, Tsuyoshi Ariga, Tadashi Hokkaido Pediatric Respiratory Infection Study Group |
| description | Recently, macrolide-resistant (MR) Mycoplasma pneumonia appeared, and prevalence of macrolide resistance among M. pneumoniae infections varies by country. However, reports on regional differences in the prevalence of MR M. pneumonia within a country are scarce. In this study, 617 nasopharyngeal swab samples were collected from 617 pediatric patients, and DNA of M. pneumoniae was identified in 95 samples. In 51 of the 95 M. pneumonia positive samples, we detected the presence of mutation A2063G mutation (conferring macrolide resistance) in the 23S rRNA gene. The overall macrolide resistance rate was 53.7%, but there were regional differences: 0.0% in Muroran, 5.3% in Asahikawa, 55.3% in Sapporo, and 100.0% in Kushiro. Statistically significant pairwise differences in the prevalence of MR M. pneumoniae were observed among these cities except for the pair of Muroran and Asahikawa. After exclusion (in order to avoid the influence of macrolides) of patients who were prescribed macrolides before collection of nasopharyngeal swab samples, statistically significant differences persisted: 0.0% in Muroran, 5.6% in Asahikawa, 38.5% in Sapporo, and 100.0% in Kushiro. |
| doi_str_mv | 10.7883/yoken.JJID.2015.054 |
| format | Article |
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However, reports on regional differences in the prevalence of MR M. pneumonia within a country are scarce. In this study, 617 nasopharyngeal swab samples were collected from 617 pediatric patients, and DNA of M. pneumoniae was identified in 95 samples. In 51 of the 95 M. pneumonia positive samples, we detected the presence of mutation A2063G mutation (conferring macrolide resistance) in the 23S rRNA gene. The overall macrolide resistance rate was 53.7%, but there were regional differences: 0.0% in Muroran, 5.3% in Asahikawa, 55.3% in Sapporo, and 100.0% in Kushiro. Statistically significant pairwise differences in the prevalence of MR M. pneumoniae were observed among these cities except for the pair of Muroran and Asahikawa. After exclusion (in order to avoid the influence of macrolides) of patients who were prescribed macrolides before collection of nasopharyngeal swab samples, statistically significant differences persisted: 0.0% in Muroran, 5.6% in Asahikawa, 38.5% in Sapporo, and 100.0% in Kushiro.</description><identifier>ISSN: 1344-6304</identifier><identifier>EISSN: 1884-2836</identifier><identifier>DOI: 10.7883/yoken.JJID.2015.054</identifier><identifier>PMID: 26166502</identifier><language>eng</language><publisher>Japan: National Institute of Infectious Diseases, Japanese Journal of Infectious Diseases Editorial Committee</publisher><subject>Anti-Bacterial Agents - pharmacology ; Child ; Drug Resistance, Bacterial - genetics ; Genes, Bacterial ; Genotype ; Humans ; Japan ; Japan - epidemiology ; macrolide resistant ; Macrolides - pharmacology ; Mycoplasma pneumoniae ; Mycoplasma pneumoniae - drug effects ; Mycoplasma pneumoniae - genetics ; Mycoplasma pneumoniae - isolation & purification ; Pneumonia, Mycoplasma - diagnosis ; Pneumonia, Mycoplasma - drug therapy ; Pneumonia, Mycoplasma - epidemiology ; Pneumonia, Mycoplasma - microbiology ; Prevalence ; Real-Time Polymerase Chain Reaction ; regional difference ; RNA, Ribosomal, 23S - genetics</subject><ispartof>Japanese Journal of Infectious Diseases, 2016, Vol.69(3), pp.186-190</ispartof><rights>Authors</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c557t-843742adb3e4802644093659c6fc76af250d505bfe5390a01df102684657d9463</citedby><cites>FETCH-LOGICAL-c557t-843742adb3e4802644093659c6fc76af250d505bfe5390a01df102684657d9463</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26166502$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ishiguro, Nobuhisa</creatorcontrib><creatorcontrib>Koseki, Naoko</creatorcontrib><creatorcontrib>Kaiho, Miki</creatorcontrib><creatorcontrib>Kikuta, Hideaki</creatorcontrib><creatorcontrib>Togashi, Takehiro</creatorcontrib><creatorcontrib>Oba, Koji</creatorcontrib><creatorcontrib>Morita, Keisuke</creatorcontrib><creatorcontrib>Nagano, Naoko</creatorcontrib><creatorcontrib>Nakanishi, Masanori</creatorcontrib><creatorcontrib>Hazama, Kyosuke</creatorcontrib><creatorcontrib>Watanabe, Toru</creatorcontrib><creatorcontrib>Sasaki, Satoshi</creatorcontrib><creatorcontrib>Horino, Atsuko</creatorcontrib><creatorcontrib>Kenri, Tsuyoshi</creatorcontrib><creatorcontrib>Ariga, Tadashi</creatorcontrib><creatorcontrib>Hokkaido Pediatric Respiratory Infection Study Group</creatorcontrib><creatorcontrib>Hokkaido Pediatric Respiratory Infection Study Group</creatorcontrib><title>Regional Differences in Prevalence of Macrolide Resistance among Pediatric Mycoplasma pneumoniae Infections in Hokkaido, Japan</title><title>Japanese Journal of Infectious Diseases</title><addtitle>Jpn J Infect Dis</addtitle><description>Recently, macrolide-resistant (MR) Mycoplasma pneumonia appeared, and prevalence of macrolide resistance among M. pneumoniae infections varies by country. However, reports on regional differences in the prevalence of MR M. pneumonia within a country are scarce. In this study, 617 nasopharyngeal swab samples were collected from 617 pediatric patients, and DNA of M. pneumoniae was identified in 95 samples. In 51 of the 95 M. pneumonia positive samples, we detected the presence of mutation A2063G mutation (conferring macrolide resistance) in the 23S rRNA gene. The overall macrolide resistance rate was 53.7%, but there were regional differences: 0.0% in Muroran, 5.3% in Asahikawa, 55.3% in Sapporo, and 100.0% in Kushiro. Statistically significant pairwise differences in the prevalence of MR M. pneumoniae were observed among these cities except for the pair of Muroran and Asahikawa. After exclusion (in order to avoid the influence of macrolides) of patients who were prescribed macrolides before collection of nasopharyngeal swab samples, statistically significant differences persisted: 0.0% in Muroran, 5.6% in Asahikawa, 38.5% in Sapporo, and 100.0% in Kushiro.</description><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Child</subject><subject>Drug Resistance, Bacterial - genetics</subject><subject>Genes, Bacterial</subject><subject>Genotype</subject><subject>Humans</subject><subject>Japan</subject><subject>Japan - epidemiology</subject><subject>macrolide resistant</subject><subject>Macrolides - pharmacology</subject><subject>Mycoplasma pneumoniae</subject><subject>Mycoplasma pneumoniae - drug effects</subject><subject>Mycoplasma pneumoniae - genetics</subject><subject>Mycoplasma pneumoniae - isolation & purification</subject><subject>Pneumonia, Mycoplasma - diagnosis</subject><subject>Pneumonia, Mycoplasma - drug therapy</subject><subject>Pneumonia, Mycoplasma - epidemiology</subject><subject>Pneumonia, Mycoplasma - microbiology</subject><subject>Prevalence</subject><subject>Real-Time Polymerase Chain Reaction</subject><subject>regional difference</subject><subject>RNA, Ribosomal, 23S - genetics</subject><issn>1344-6304</issn><issn>1884-2836</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAQhiMEoqXwC5CQjxzI4vgrzhG1he6qFVUFZ2vWGS_uJnaws0h74beTdJeVOHHx5zPvSPMUxduKLmqt-cd93GJYrFbLqwWjlVxQKZ4V55XWomSaq-fTmQtRKk7FWfEq50dKmZQVfVmcMVUpJSk7L34_4MbHAB258s5hwmAxEx_IfcJf0M1XEh25A5ti51skD5h9HmF-hz6GDbnH1sOYvCV3exuHDnIPZAi4m349IFkGh3acejzF3sTtFnwbP5AVDBBeFy8cdBnfHPeL4vvn62-XN-Xt1y_Ly0-3pZWyHksteC0YtGuOQlOmhKANV7KxytlagWOStpLKtUPJGwq0al01YVooWbeNUPyieH_IHVL8ucM8mt5ni10HAeMum0pTrbiQVP8frRvaMKabOZUf0Gk4OSd0Zki-h7Q3FTWzI_PkyMyOzOzITI6mqnfHBrt1j-2p5q-UCVgegMdp0Bs8AZBGbzs8hqrG8Hn5J_zE2B-QDAb-B5BKqPM</recordid><startdate>20160520</startdate><enddate>20160520</enddate><creator>Ishiguro, Nobuhisa</creator><creator>Koseki, Naoko</creator><creator>Kaiho, Miki</creator><creator>Kikuta, Hideaki</creator><creator>Togashi, Takehiro</creator><creator>Oba, Koji</creator><creator>Morita, Keisuke</creator><creator>Nagano, Naoko</creator><creator>Nakanishi, Masanori</creator><creator>Hazama, Kyosuke</creator><creator>Watanabe, Toru</creator><creator>Sasaki, Satoshi</creator><creator>Horino, Atsuko</creator><creator>Kenri, Tsuyoshi</creator><creator>Ariga, Tadashi</creator><creator>Hokkaido Pediatric Respiratory Infection Study Group</creator><general>National Institute of Infectious Diseases, Japanese Journal of Infectious Diseases Editorial Committee</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QL</scope><scope>C1K</scope></search><sort><creationdate>20160520</creationdate><title>Regional Differences in Prevalence of Macrolide Resistance among Pediatric Mycoplasma pneumoniae Infections in Hokkaido, Japan</title><author>Ishiguro, Nobuhisa ; 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However, reports on regional differences in the prevalence of MR M. pneumonia within a country are scarce. In this study, 617 nasopharyngeal swab samples were collected from 617 pediatric patients, and DNA of M. pneumoniae was identified in 95 samples. In 51 of the 95 M. pneumonia positive samples, we detected the presence of mutation A2063G mutation (conferring macrolide resistance) in the 23S rRNA gene. The overall macrolide resistance rate was 53.7%, but there were regional differences: 0.0% in Muroran, 5.3% in Asahikawa, 55.3% in Sapporo, and 100.0% in Kushiro. Statistically significant pairwise differences in the prevalence of MR M. pneumoniae were observed among these cities except for the pair of Muroran and Asahikawa. After exclusion (in order to avoid the influence of macrolides) of patients who were prescribed macrolides before collection of nasopharyngeal swab samples, statistically significant differences persisted: 0.0% in Muroran, 5.6% in Asahikawa, 38.5% in Sapporo, and 100.0% in Kushiro.</abstract><cop>Japan</cop><pub>National Institute of Infectious Diseases, Japanese Journal of Infectious Diseases Editorial Committee</pub><pmid>26166502</pmid><doi>10.7883/yoken.JJID.2015.054</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Japanese Journal of Infectious Diseases, 2016, Vol.69(3), pp.186-190 |
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| subjects | Anti-Bacterial Agents - pharmacology Child Drug Resistance, Bacterial - genetics Genes, Bacterial Genotype Humans Japan Japan - epidemiology macrolide resistant Macrolides - pharmacology Mycoplasma pneumoniae Mycoplasma pneumoniae - drug effects Mycoplasma pneumoniae - genetics Mycoplasma pneumoniae - isolation & purification Pneumonia, Mycoplasma - diagnosis Pneumonia, Mycoplasma - drug therapy Pneumonia, Mycoplasma - epidemiology Pneumonia, Mycoplasma - microbiology Prevalence Real-Time Polymerase Chain Reaction regional difference RNA, Ribosomal, 23S - genetics |
| title | Regional Differences in Prevalence of Macrolide Resistance among Pediatric Mycoplasma pneumoniae Infections in Hokkaido, Japan |
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