Chloroquine promotes IL-17 production by CD4+ T cells via p38-dependent IL-23 release by monocyte-derived Langerhans-like cells

Recent studies suggest a role for autophagy in the secretion of IL-1 cytokines regulating the development of inflammatory diseases. The antimalarial drug and autophagy/lysosome inhibitor chloroquine (CHQ) is considered as potential trigger of drug-induced or drug-aggravated psoriasis, in which Th17...

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Veröffentlicht in:	The Journal of immunology (1950) 2014-12, Vol.193 (12), p.6135-6143
Hauptverfasser:	Said, André, Bock, Stephanie, Lajqi, Trim, Müller, Gerrit, Weindl, Günther
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism CD4-Positive T-Lymphocytes - drug effects CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - metabolism Cell Differentiation Chloroquine - pharmacology Coculture Techniques Cytokines - biosynthesis Cytokines - genetics Dendritic Cells - immunology Dendritic Cells - metabolism Gene Expression Regulation - drug effects Humans Interleukin-1 - pharmacology Interleukin-12 - biosynthesis Interleukin-17 - biosynthesis Interleukin-23 - biosynthesis Langerhans Cells - cytology Langerhans Cells - metabolism Microtubule-Associated Proteins - genetics Microtubule-Associated Proteins - metabolism Monocytes - cytology Monocytes - metabolism p38 Mitogen-Activated Protein Kinases - metabolism Protein-Serine-Threonine Kinases - metabolism Receptors, Interleukin-1 - antagonists & inhibitors Receptors, Transforming Growth Factor beta - metabolism Sequestosome-1 Protein Signal Transduction Th1 Cells - drug effects Th1 Cells - immunology Th1 Cells - metabolism TNF Receptor-Associated Factor 6 - genetics TNF Receptor-Associated Factor 6 - metabolism
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